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  1. Better phenotyping of routinely collected coded data would be useful for research and health improvement. For example, the precision of coded data for hemorrhagic stroke (intracerebral hemorrhage [ICH] and sub...

    Authors: Kristiina Rannikmäe, Honghan Wu, Steven Tominey, William Whiteley, Naomi Allen and Cathie Sudlow

    Citation: BMC Medical Informatics and Decision Making 2021 21:191

    Content type: Research

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  2. Linking Brazilian databases demands the development of algorithms and processes to deal with various challenges including the large size of the databases, the low number and poor quality of personal identifier...

    Authors: Claudia Medina Coeli, Valeria Saraceni, Paulo Mota Medeiros Jr., Helena Pereira da Silva Santos, Luis Carlos Torres Guillen, Luís Guilherme Santos Buteri Alves, Thomas Hone, Christopher Millett, Anete Trajman and Betina Durovni

    Citation: BMC Medical Informatics and Decision Making 2021 21:190

    Content type: Research article

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  3. Despite regional efforts to address concerns regarding the burden of advanced cancer in Africa, urgent attention is still required. Widespread issues include late symptom presentation, inaccessibility of palli...

    Authors: Eve Namisango, Lauren Ramsey, Adlight Dandadzi, Kehinde Okunade, Bassey Ebenso and Matthew J. Allsop

    Citation: BMC Medical Informatics and Decision Making 2021 21:189

    Content type: Research

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  4. Trust is widely recognized as a crucial factor in successful physician–patient communication and patient engagement in treatment. However, with the rise of eHealth technologies, such as online patient portals,...

    Authors: Lex van Velsen, Ina Flierman and Monique Tabak

    Citation: BMC Medical Informatics and Decision Making 2021 21:188

    Content type: Research article

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  5. Extensive clinical evidence suggests that a preventive screening of coronary heart disease (CHD) at an earlier stage can greatly reduce the mortality rate. We use 64 two-dimensional speckle tracking echocardio...

    Authors: Jingyi Zhang, Huolan Zhu, Yongkai Chen, Chenguang Yang, Huimin Cheng, Yi Li, Wenxuan Zhong and Fang Wang

    Citation: BMC Medical Informatics and Decision Making 2021 21:187

    Content type: Research article

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  6. Out of the pressure of Digital Transformation, the major industrial domains are using advanced and efficient digital technologies to implement processes that are applied on a daily basis. Unfortunately, this s...

    Authors: Juan G. Diaz Ochoa, Orsolya Csiszár and Thomas Schimper

    Citation: BMC Medical Informatics and Decision Making 2021 21:186

    Content type: Research

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  7. The use of information technology can make pulmonary rehabilitation interventions in people with chronic obstructive pulmonary disease (COPD) more flexible and thereby has the potential to reach a larger propo...

    Authors: Pernilla Sönnerfors, Kirsti Skavberg Roaldsen, Agneta Ståhle, Karin Wadell and Alexandra Halvarsson

    Citation: BMC Medical Informatics and Decision Making 2021 21:185

    Content type: Research

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  8. Heart disease diagnosis is a challenging task and it is important to explore useful information from the massive amount of electrocardiogram (ECG) records of patients. The high-precision diagnostic identificat...

    Authors: Chao Che, Peiliang Zhang, Min Zhu, Yue Qu and Bo Jin

    Citation: BMC Medical Informatics and Decision Making 2021 21:184

    Content type: Research

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  9. Electronic Health Records (EHRs) are now widely used to create a single, shared, and reliable source of patient data throughout healthcare organizations. However, health professionals continue to experience mi...

    Authors: Albert Boonstra, Tess L. Jonker, Marjolein A. G. van Offenbeek and Janita F. J. Vos

    Citation: BMC Medical Informatics and Decision Making 2021 21:183

    Content type: Research

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  10. Early diagnosis for the diabetes complications is clinically demanding with great significancy. Regarding the complexity of diabetes complications, we applied a multi-label classification (MLC) model to predic...

    Authors: Liang Zhou, Xiaoyuan Zheng, Di Yang, Ying Wang, Xuesong Bai and Xinhua Ye

    Citation: BMC Medical Informatics and Decision Making 2021 21:182

    Content type: Research

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  11. In Japan, a multiple-hospital observational database system, the Medical Information Database Network (MID-NET®), was launched for post-marketing drug safety assessments. These assessments will be based on dat...

    Authors: Maki Komamine, Yoshiaki Fujimura, Yasuharu Nitta, Masatomo Omiya, Masaaki Doi and Tosiya Sato

    Citation: BMC Medical Informatics and Decision Making 2021 21:181

    Content type: Research article

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  12. Women with pathogenic BRCA1 and BRCA2 mutations possess a high risk of developing breast and ovarian cancer. They face difficult choices when considering preventive options. This study presents the development pr...

    Authors: Sibylle Kautz-Freimuth, Marcus Redaèlli, Kerstin Rhiem, Andrea Vodermaier, Lisa Krassuski, Kathrin Nicolai, Miriam Schnepper, Violetta Kuboth, Julia Dick, Vera Vennedey, Regina Wiedemann, Rita Schmutzler and Stephanie Stock

    Citation: BMC Medical Informatics and Decision Making 2021 21:180

    Content type: Research article

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  13. Natural language processing (NLP) has a significant role in advancing healthcare and has been found to be key in extracting structured information from radiology reports. Understanding recent developments in N...

    Authors: Arlene Casey, Emma Davidson, Michael Poon, Hang Dong, Daniel Duma, Andreas Grivas, Claire Grover, Víctor Suárez-Paniagua, Richard Tobin, William Whiteley, Honghan Wu and Beatrice Alex

    Citation: BMC Medical Informatics and Decision Making 2021 21:179

    Content type: Research

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  15. The ability to prioritize people living with HIV (PLWH) by risk of future transmissions could aid public health officials in optimizing epidemiological intervention. While methods exist to perform such priorit...

    Authors: Kimberly Almaraz, Tyler Jang, McKenna Lewis, Titan Ngo, Miranda Song and Niema Moshiri

    Citation: BMC Medical Informatics and Decision Making 2021 21:177

    Content type: Software

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  16. Different endometrial patterns have an important effect on the relationship between endometrial thickness (EMT) and clinical pregnancy rate. There is a significant difference in age, selection of cycle protoco...

    Authors: ShuJie Liao, Renjie Wang, Cheng Hu, Wulin Pan, Wei Pan, Dongyang Yu and Lei Jin

    Citation: BMC Medical Informatics and Decision Making 2021 21:176

    Content type: Research article

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  17. Accurate, comprehensive, cause-specific mortality estimates are crucial for informing public health decision making worldwide. Incorrectly or vaguely assigned deaths, defined as garbage-coded deaths, mask the ...

    Authors: Sarah Charlotte Johnson, Matthew Cunningham, Ilse N. Dippenaar, Fablina Sharara, Eve E. Wool, Kareha M. Agesa, Chieh Han, Molly K. Miller-Petrie, Shadrach Wilson, John E. Fuller, Shelly Balassyano, Gregory J. Bertolacci, Nicole Davis Weaver, Alan D. Lopez, Christopher J. L. Murray and Mohsen Naghavi

    Citation: BMC Medical Informatics and Decision Making 2021 21:175

    Content type: Research article

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  18. Validation of the autoverification function is one of the critical steps to confirm its effectiveness before use. It is crucial to verify whether the programmed algorithm follows the expected logic and produce...

    Authors: Di Jin, Qing Wang, Dezhi Peng, Jiajia Wang, Bijuan Li, Yating Cheng, Nanxun Mo, Xiaoyan Deng and Ran Tao

    Citation: BMC Medical Informatics and Decision Making 2021 21:174

    Content type: Research

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  19. The promotion of early diagnosis is undoubtedly effective in reducing the burden of disease. Contrast-enhanced ultrasound (CEUS) is a diagnostic technology for liver cancer, but its implementation faces some c...

    Authors: Qingwen Deng, Yuhang Zheng, Junhong Lu, Zhichao Zeng and Wenbin Liu

    Citation: BMC Medical Informatics and Decision Making 2021 21:173

    Content type: Research article

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  21. Adverse drug reactions (ADRs) are statistically characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. This is true ev...

    Authors: Emmanuel Bresso, Pierre Monnin, Cédric Bousquet, François-Elie Calvier, Ndeye-Coumba Ndiaye, Nadine Petitpain, Malika Smaïl-Tabbone and Adrien Coulet

    Citation: BMC Medical Informatics and Decision Making 2021 21:171

    Content type: Research article

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  22. Coronavirus disease 2019 (COVID-19) has become a pandemic since its first appearance in late 2019. Deaths caused by COVID-19 are still increasing day by day and early diagnosis has become crucial. Since curren...

    Authors: Mehmet Akif Ozdemir, Gizem Dilara Ozdemir and Onan Guren

    Citation: BMC Medical Informatics and Decision Making 2021 21:170

    Content type: Research

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  23. Evidence to Decision (EtD) frameworks bring clarity, structure and transparency to health care decision making. The interactive Evidence to Decision (iEtD) tool, developed in the context of the DECIDE project ...

    Authors: Jose Francisco Meneses-Echavez, Sarah Rosenbaum, Gabriel Rada, Signe Flottorp, Jenny Moberg and Pablo Alonso-Coello

    Citation: BMC Medical Informatics and Decision Making 2021 21:169

    Content type: Research

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  24. Assessing the accuracy of diagnostic coding is essential to ensure the validity and reliability of administrative coded data. The aim of the study was to evaluate the accuracy of assigned International Classif...

    Authors: Nasir Wabe, Ling Li, Robert Lindeman, Jeffrey J. Post, Maria R. Dahm, Julie Li, Johanna I. Westbrook and Andrew Georgiou

    Citation: BMC Medical Informatics and Decision Making 2021 21:168

    Content type: Research article

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  25. Interventional studies are the fundamental method for obtaining answers to clinical questions. However, these studies are sometimes difficult to conduct because of insufficient financial or human resources or ...

    Authors: Yumi Wakabayashi, Masamitsu Eitoku and Narufumi Suganuma

    Citation: BMC Medical Informatics and Decision Making 2021 21:167

    Content type: Research article

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  26. The demand for home healthcare devices arises; however, many home healthcare devices on the market are not designed to reflect the needs and features of the end-users. This study explored the user knowledge fa...

    Authors: Fan Yang, Abdullah Al Mahmud and Tao Wang

    Citation: BMC Medical Informatics and Decision Making 2021 21:166

    Content type: Research article

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  27. Several epidemiological and cohort studies suggest that regular low-dose aspirin use independently reduces the long-term incidence and risk of colorectal cancer deaths by approximately 20%. However, there are ...

    Authors: Lenira Semedo, Kate J. Lifford, Adrian Edwards, Kathy Seddon, Kate Brain, Stephanie Smits and Sunil Dolwani

    Citation: BMC Medical Informatics and Decision Making 2021 21:165

    Content type: Research article

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  28. Robust identification of surrogate endpoints can help accelerate the development of pharmacotherapies for diseases traditionally evaluated using true endpoints associated with prolonged follow-up. The meta-ana...

    Authors: Milan Geybels, Benjamin Ole Wolthers, Frederik Flindt Kreiner, Søren Rasmussen and Robert Bauer

    Citation: BMC Medical Informatics and Decision Making 2021 21:164

    Content type: Technical advance

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  29. Sepsis is a severe illness that affects millions of people worldwide, and its early detection is critical for effective treatment outcomes. In recent years, researchers have used models to classify positive pa...

    Authors: Márcio Freire Cruz, Naoaki Ono, Ming Huang, Md. Altaf-Ul-Amin, Shigehiko Kanaya and Carlos Arthur Mattos Teixeira Cavalcante

    Citation: BMC Medical Informatics and Decision Making 2021 21:163

    Content type: Research

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  30. Heterogeneity among patients’ responses to treatment is prevalent in psychiatric disorders. Personalized medicine approaches—which involve parsing patients into subgroups better indicated for a particular trea...

    Authors: Monika S. Mellem, Matt Kollada, Jane Tiller and Thomas Lauritzen

    Citation: BMC Medical Informatics and Decision Making 2021 21:162

    Content type: Research article

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  31. Current management of children with minor head trauma (MHT) and intracranial injuries is not evidence-based and may place some children at risk of harm. Evidence-based electronic clinical decision support (CDS...

    Authors: Jacob K. Greenberg, Ayodamola Otun, Azzah Nasraddin, Ross C. Brownson, Nathan Kuppermann, David D. Limbrick, Po-Yin Yen and Randi E. Foraker

    Citation: BMC Medical Informatics and Decision Making 2021 21:161

    Content type: Research article

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  32. The variety of medical documentation often leads to incompatible data elements that impede data integration between institutions. A common approach to standardize and distribute metadata definitions are ISO/IE...

    Authors: Stefan Hegselmann, Michael Storck, Sophia Gessner, Philipp Neuhaus, Julian Varghese, Philipp Bruland, Alexandra Meidt, Cornelia Mertens, Sarah Riepenhausen, Sonja Baier, Benedikt Stöcker, Jörg Henke, Carsten Oliver Schmidt and Martin Dugas

    Citation: BMC Medical Informatics and Decision Making 2021 21:160

    Content type: Research article

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  33. Adverse drug reactions (ADRs) are regarded as a major cause of death and a major contributor to public health costs. For the active surveillance of drug safety, the use of real-world data and real-world eviden...

    Authors: Hyunah Shin and Suehyun Lee

    Citation: BMC Medical Informatics and Decision Making 2021 21:159

    Content type: Research article

    Published on:

  34. Malaria is a major cause of death in children under five years old in low- and middle-income countries such as Malawi. Accurate diagnosis and management of malaria can help reduce the global burden of childhoo...

    Authors: Sanya B. Taneja, Gerald P. Douglas, Gregory F. Cooper, Marian G. Michaels, Marek J. Druzdzel and Shyam Visweswaran

    Citation: BMC Medical Informatics and Decision Making 2021 21:158

    Content type: Research article

    Published on:

  35. Patient satisfaction is a multi-dimensional concept that provides insights into various quality aspects in healthcare. Although earlier studies identified a range of patient and provider-related determinants, ...

    Authors: Mecit Can Emre Simsekler, Noura Hamed Alhashmi, Elie Azar, Nelson King, Rana Adel Mahmoud Ali Luqman and Abdalla Al Mulla

    Citation: BMC Medical Informatics and Decision Making 2021 21:157

    Content type: Research article

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  36. Severity scores assess the acuity of critical illness by penalizing for the deviation of physiologic measurements from normal and aggregating these penalties (also called “weights” or “subscores”) into a final...

    Authors: Yasser EL-Manzalawy, Mostafa Abbas, Ian Hoaglund, Alvaro Ulloa Cerna, Thomas B. Morland, Christopher M. Haggerty, Eric S. Hall and Brandon K. Fornwalt

    Citation: BMC Medical Informatics and Decision Making 2021 21:156

    Content type: Research article

    Published on:

  37. Injuries are a major health issue worldwide and their prevention requires access to accurate statistics in this regard. This can be achieved by classifying the collected data using the international classifica...

    Authors: Leila Ahmadian, Fatemeh Salehi and Shabnam Padidar

    Citation: BMC Medical Informatics and Decision Making 2021 21:155

    Content type: Research article

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  38. While many studies have tested the impact of a decision aid (DA) compared to not receiving any DA, far fewer have tested how different types of DAs affect key outcomes such as treatment choice, patient–provide...

    Authors: Angela Fagerlin, Margaret Holmes-Rovner, Timothy P. Hofer, David Rovner, Stewart C. Alexander, Sara J. Knight, Bruce S. Ling, James A.Tulsky, John T. Wei, Khaled Hafez, Valerie C. Kahn, Daniel Connochie, Jeffery Gingrich and Peter A. Ubel

    Citation: BMC Medical Informatics and Decision Making 2021 21:154

    Content type: Research article

    Published on:

  39. Adherence and motivation are key factors for successful treatment of patients with chronic diseases, especially in long-term care processes like rehabilitation. However, only a few patients achieve good treatm...

    Authors: Bianca Steiner, Birgit Saalfeld, Lena Elgert, Reinhold Haux and Klaus-Hendrik Wolf

    Citation: BMC Medical Informatics and Decision Making 2021 21:153

    Content type: Research

    Published on:

  40. Mechanical Ventilation (MV) is a complex and central treatment process in the care of critically ill patients. It influences acid–base balance and can also cause prognostically relevant biotrauma by generating...

    Authors: Behrooz Mamandipoor, Fernando Frutos-Vivar, Oscar Peñuelas, Richard Rezar, Konstantinos Raymondos, Alfonso Muriel, Bin Du, Arnaud W. Thille, Fernando Ríos, Marco González, Lorenzo del-Sorbo, Maria del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolas Nin, Salvatore M. Maggiore…

    Citation: BMC Medical Informatics and Decision Making 2021 21:152

    Content type: Research article

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  41. Despite the proven value of multicriteria decision analysis in the health field, there is a lack of studies focused on prioritising victims in the Emergency Medical Service, EMS. With this, and knowing that th...

    Authors: Talita D. C. Frazão, Ana F. A. dos Santos, Deyse G. G. Camilo, João Florêncio da Costa Júnior and Ricardo P. de Souza

    Citation: BMC Medical Informatics and Decision Making 2021 21:151

    Content type: Research article

    Published on:

  42. Older adults and elderly persons can experience a significant digital divide. However, there are many studies reporting that the use of the Internet has benefits related to a person’s health status and social ...

    Authors: Mariusz Duplaga

    Citation: BMC Medical Informatics and Decision Making 2021 21:150

    Content type: Research article

    Published on:

  43. Transjugular intrahepatic portosystemic shunt (TIPS) procedure is an established procedure carried out by interventional radiologists to achieve portal decompression and to manage the complications of portal h...

    Authors: Sean-Tee J. M. Lim, Martin Kelly, Logeswaran Selvarajah, Michael Murray and Timothy Scanlon

    Citation: BMC Medical Informatics and Decision Making 2021 21:149

    Content type: Research

    Published on:

  44. In 2017, the Centers for Medicare and Medicaid Services required all long-term care facilities, including nursing homes, to have an antibiotic stewardship program. Many nursing homes lack the resources, expert...

    Authors: Sunah Song, Brigid M. Wilson, Joseph Marek and Robin L. P. Jump

    Citation: BMC Medical Informatics and Decision Making 2021 21:148

    Content type: Technical advance

    Published on:

  45. Tongue diagnosis is an important research field of TCM diagnostic technology modernization. The quality of tongue images is the basis for constructing a standard dataset in the field of tongue diagnosis. To es...

    Authors: Tao Jiang, Xiao-juan Hu, Xing-hua Yao, Li-ping Tu, Jing-bin Huang, Xu-xiang Ma, Ji Cui, Qing-feng Wu and Jia-tuo Xu

    Citation: BMC Medical Informatics and Decision Making 2021 21:147

    Content type: Research article

    Published on:

  46. Knowledge management technology is a key tool for facilitating and improving the quality of health care delivery in hospitals. However, the use and implementation of this technology is not an easy task. This s...

    Authors: Mniyichel Belay, Amare Desta, Steve Smithson and Million Meshesha

    Citation: BMC Medical Informatics and Decision Making 2021 21:146

    Content type: Research

    Published on:

  47. Controlled vocabularies are fundamental resources for information extraction from clinical texts using natural language processing (NLP). Standard language resources available in the healthcare domain such as ...

    Authors: Pilar López-Úbeda, Alexandra Pomares-Quimbaya, Manuel Carlos Díaz-Galiano and Stefan Schulz

    Citation: BMC Medical Informatics and Decision Making 2021 21:145

    Content type: Research

    Published on:

  48. In high-dimensional data analysis, the complexity of predictive models can be reduced by selecting the most relevant features, which is crucial to reduce data noise and increase model accuracy and interpretabi...

    Authors: Pierre Michel, Nicolas Ngo, Jean-François Pons, Stéphane Delliaux and Roch Giorgi

    Citation: BMC Medical Informatics and Decision Making 2021 21(Suppl 4):130

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 4

  49. Protein–protein interactions (PPIs) are the core of protein function, which provide an effective means to understand the function at cell level. Identification of PPIs is the crucial foundation of predicting d...

    Authors: Xiaoli Lin and Xiaolong Zhang

    Citation: BMC Medical Informatics and Decision Making 2021 21(Suppl 1):143

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  50. In many cases, both the rupture rate of cerebral arteriovenous malformation (bAVM) in patients and the risk of endovascular or surgical treatment (when radiosurgery is not appropriate) are not low, it is impor...

    Authors: Wengui Tao, Langchao Yan, Ming Zeng and Fenghua Chen

    Citation: BMC Medical Informatics and Decision Making 2021 21:142

    Content type: Research

    Published on:

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