Articles

Physicians’ pharmacogenomics information needs and seeking behavior: a study with case vignettes

Genetic testing, especially in pharmacogenomics, can have a major impact on patient care. However, most physicians do not feel that they have sufficient knowledge to apply pharmacogenomics to patient care. Onl...

Authors: Bret S. E. Heale, Aly Khalifa, Bryan L. Stone, Scott Nelson and Guilherme Del Fiol

Developing a patient decision aid for the treatment of women with early stage breast cancer: the struggle between simplicity and complexity

A patient decision aid (PtDA) can support shared decision making (SDM) in preference-sensitive care, with more than one clinically applicable treatment option. The development of a PtDA is a complex process, i...

Authors: W. Savelberg, T. van der Weijden, L. Boersma, M. Smidt, C. Willekens and A. Moser

Predicting progression of mild cognitive impairment to dementia using neuropsychological data: a supervised learning approach using time windows

Predicting progression from a stage of Mild Cognitive Impairment to dementia is a major pursuit in current research. It is broadly accepted that cognition declines with a continuum between MCI and dementia. As...

Authors: Telma Pereira, Luís Lemos, Sandra Cardoso, Dina Silva, Ana Rodrigues, Isabel Santana, Alexandre de Mendonça, Manuela Guerreiro and Sara C. Madeira

Utilizing patient data from the veterans administration electronic health record to support web-based clinical decision support: informatics challenges and issues from three clinical domains

The US Veterans Administration (VA) has developed a robust and mature computational infrastructure in support of its electronic health record (EHR). Web technology offers a powerful set of tools for structurin...

Authors: Nallakkandi Rajeevan, Kristina M. Niehoff, Peter Charpentier, Forrest L. Levin, Amy Justice, Cynthia A. Brandt, Terri R. Fried and Perry L. Miller

An information and communication technology-based centralized clinical trial to determine the efficacy and safety of insulin dose adjustment education based on a smartphone personal health record application: a randomized controlled trial

A Personal Health Record (PHR) is an online application that allows patients to access, manage, and share their health data. PHRs not only enhance shared decision making with healthcare providers, but also ena...

Authors: Gyuri Kim, Ji Cheol Bae, Byoung Kee Yi, Kyu Yeon Hur, Dong Kyung Chang, Moon-Kyu Lee, Jae Hyeon Kim and Sang-Man Jin

Evaluation of record linkage of two large administrative databases in a middle income country: stillbirths and notifications of dengue during pregnancy in Brazil

Due to the increasing availability of individual-level information across different electronic datasets, record linkage has become an efficient and important research tool. High quality linkage is essential fo...

Authors: Enny S Paixão, Katie Harron, Kleydson Andrade, Maria Glória Teixeira, Rosemeire L. Fiaccone, Maria da Conceição N. Costa and Laura C. Rodrigues

Validation of multisource electronic health record data: an application to blood transfusion data

Although data from electronic health records (EHR) are often used for research purposes, systematic validation of these data prior to their use is not standard practice. Existing validation frameworks discuss ...

Authors: Loan R. van Hoeven, Martine C. de Bruijne, Peter F. Kemper, Maria M.W. Koopman, Jan M.M. Rondeel, Anja Leyte, Hendrik Koffijberg, Mart P. Janssen and Kit C.B. Roes

Utility-preserving anonymization for health data publishing

Publishing raw electronic health records (EHRs) may be considered as a breach of the privacy of individuals because they usually contain sensitive information. A common practice for the privacy-preserving data...

Authors: Hyukki Lee, Soohyung Kim, Jong Wook Kim and Yon Dohn Chung

Using a linked database for epidemiology across the primary and secondary care divide: acute kidney injury

NHS England has mandated the use in hospital laboratories of an automated early warning algorithm to create a consistent method for the detection of acute kidney injury (AKI). It generates an ‘alert’ based on ...

Authors: M. Johnson, H. Hounkpatin, S. Fraser, D. Culliford, M. Uniacke and P. Roderick

Hospital staffs’ perceptions of an electronic program to engage patients in nutrition care at the bedside: a qualitative study

Advancements in technology are enabling patients to participate in their health care through self-monitoring and self-management of diet, exercise and chronic disease. Technologies allowing patients to partici...

Authors: Shelley Roberts, Andrea Marshall and Wendy Chaboyer

Medical diagnosis as a linguistic game

We present a formalized medical knowledge system using a linguistic approach combined with a semantic net.

Authors: Peter Fritz, Andreas Kleinhans, Florian Kuisle, Patricius Albu, Christine Fritz-Kuisle and Mark Dominik Alscher

The development and feasibility of a personal health-optimization system for people with bipolar disorder

People with bipolar disorder often experience ill health and have considerably reduced life expectancies. Suboptimal treatment is common and includes a lack of effective medicines, overtreatment, and non-adher...

Authors: Øystein Eiring, Kari Nytrøen, Simone Kienlin, Soudabeh Khodambashi and Magne Nylenna

Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design

With the goal of realizing genome-based personalized healthcare, we have developed a biobank that integrates personal health, genome, and omics data along with biospecimens donated by volunteers of 150,000. Su...

Authors: Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi…

Impact of mobile phone-based technology to improve health, population and nutrition services in Rural Bangladesh: a study protocol

Mobile phone-based technology has been used in improving the delivery of healthcare services in many countries. However, data on the effects of this technology on improving primary healthcare services in resou...

Authors: Jasim Uddin, Tuhin Biswas, Gourab Adhikary, Wazed Ali, Nurul Alam, Rajesh Palit, Nizam Uddin, Aftab Uddin, Fatema Khatun and Abbas Bhuiya

Predictive models for pressure ulcers from intensive care unit electronic health records using Bayesian networks

We develop predictive models enabling clinicians to better understand and explore patient clinical data along with risk factors for pressure ulcers in intensive care unit patients from electronic health record...

Authors: Pacharmon Kaewprag, Cheryl Newton, Brenda Vermillion, Sookyung Hyun, Kun Huang and Raghu Machiraju

Detecting clinically relevant new information in clinical notes across specialties and settings

Automated methods for identifying clinically relevant new versus redundant information in electronic health record (EHR) clinical notes is useful for clinicians and researchers involved in patient care and cli...

Authors: Rui Zhang, Serguei V. S. Pakhomov, Elliot G. Arsoniadis, Janet T. Lee, Yan Wang and Genevieve B. Melton

Predicting two-year survival versus non-survival after first myocardial infarction using machine learning and Swedish national register data

Machine learning algorithms hold potential for improved prediction of all-cause mortality in cardiovascular patients, yet have not previously been developed with high-quality population data. This study compar...

Authors: John Wallert, Mattia Tomasoni, Guy Madison and Claes Held

Developing a similarity searching module for patient safety event reporting system using semantic similarity measures

The most important knowledge in the field of patient safety is regarding the prevention and reduction of patient safety events (PSE) during treatment and care. The similarities and patterns among the events ma...

Authors: Hong Kang and Yang Gong

Evaluation of the informatician perspective: determining types of research papers preferred by clinicians

To deliver evidence-based medicine, clinicians often reference resources that are useful to their respective medical practices. Owing to their busy schedules, however, clinicians typically find it challenging ...

Authors: Boshu Ru, Xiaoyan Wang and Lixia Yao

Using participatory methods to design an mHealth intervention for a low income country, a case study in Chikwawa, Malawi

mHealth holds the potential to educate rural communities in developing countries such as Malawi, on issues which over-burdened and under staffed health centres do not have the facilities to address. Previous r...

Authors: Rebecca Laidlaw, Diane Dixon, Tracy Morse, Tara K. Beattie, Save Kumwenda and Grant Mpemberera

Lightweight predicate extraction for patient-level cancer information and ontology development

Knowledge engineering for ontological knowledgebases is resource and time intensive. To alleviate these issues, especially for novices, automated tools from the natural language domain can assist in the develo...

Authors: Muhammad Amith, Hsing-Yi Song, Yaoyun Zhang, Hua Xu and Cui Tao

An active learning-enabled annotation system for clinical named entity recognition

Active learning (AL) has shown the promising potential to minimize the annotation cost while maximizing the performance in building statistical natural language processing (NLP) models. However, very few studi...

Authors: Yukun Chen, Thomas A. Lask, Qiaozhu Mei, Qingxia Chen, Sungrim Moon, Jingqi Wang, Ky Nguyen, Tolulola Dawodu, Trevor Cohen, Joshua C. Denny and Hua Xu

Electronic Health Record Portal Adoption: a cross country analysis

This study’s goal is to understand the factors that drive individuals to adopt Electronic Health Record (EHR) portals and to estimate if there are differences between countries with different healthcare models.

Authors: Jorge Tavares and Tiago Oliveira

Entity recognition from clinical texts via recurrent neural network

Entity recognition is one of the most primary steps for text analysis and has long attracted considerable attention from researchers. In the clinical domain, various types of entities, such as clinical entitie...

Authors: Zengjian Liu, Ming Yang, Xiaolong Wang, Qingcai Chen, Buzhou Tang, Zhe Wang and Hua Xu

Introduction: the International Conference on Intelligent Biology and Medicine (ICIBM) 2016: special focus on medical informatics and big data

In this editorial, we first summarize the 2016 International Conference on Intelligent Biology and Medicine (ICIBM 2016) held on December 8–10, 2016 in Houston, Texas, USA, and then briefly introduce the ten r...

Authors: Cui Tao, Yang Gong, Hua Xu and Zhongming Zhao

How the public uses social media wechat to obtain health information in china: a survey study

On average, 570 million users, 93% in China’s first-tier cities, log on to WeChat every day. WeChat has become the most widely and frequently used social media in China, and has been profoundly integrated into...

Authors: Xingting Zhang, Dong Wen, Jun Liang and Jianbo Lei

Leveraging machine learning-based approaches to assess human papillomavirus vaccination sentiment trends with Twitter data

As one of the serious public health issues, vaccination refusal has been attracting more and more attention, especially for newly approved human papillomavirus (HPV) vaccines. Understanding public opinion towa...

Authors: Jingcheng Du, Jun Xu, Hsing-Yi Song and Cui Tao

A signal detection method for temporal variation of adverse effect with vaccine adverse event reporting system data

To identify safety signals by manual review of individual report in large surveillance databases is time consuming; such an approach is very unlikely to reveal complex relationships between medications and adv...

Authors: Yi Cai, Jingcheng Du, Jing Huang, Susan S. Ellenberg, Sean Hennessy, Cui Tao and Yong Chen

Evaluation of rational nonsteroidal anti-inflammatory drugs and gastro-protective agents use; association rule data mining using outpatient prescription patterns

Nonsteroidal anti-inflammatory drugs (NSAIDs) and gastro-protective agents should be co-prescribed following a standard clinical practice guideline; however, adherence to this guideline in routine practice is ...

Authors: Oraluck Pattanaprateep, Mark McEvoy, John Attia and Ammarin Thakkinstian

Semantic relatedness and similarity of biomedical terms: examining the effects of recency, size, and section of biomedical publications on the performance of word2vec

Understanding semantic relatedness and similarity between biomedical terms has a great impact on a variety of applications such as biomedical information retrieval, information extraction, and recommender syst...

Authors: Yongjun Zhu, Erjia Yan and Fei Wang

Lost in translation? A multilingual Query Builder improves the quality of PubMed queries: a randomised controlled trial

MEDLINE is the most widely used medical bibliographic database in the world. Most of its citations are in English and this can be an obstacle for some researchers to access the information the database contain...

Authors: Matthieu Schuers, Mher Joulakian, Gaetan Kerdelhué, Léa Segas, Julien Grosjean, Stéfan J. Darmoni and Nicolas Griffon

A Bayesian network and heuristic approach for systematic characterization of radiotherapy receipt after breast-conservation surgery

Breast-conservation surgery with radiotherapy is a treatment highly recommended by the guidelines from the National Comprehensive Cancer Network. However, several variables influence the final receipt of radio...

Authors: Milton Soto-Ferrari, Diana Prieto and Gitonga Munene

Implementing technology in healthcare: insights from physicians

Technology has significantly changed the way health organizations operate. However, the role it plays in healthcare systems remains unclear. This aim of this study was to evaluate the opinion of physicians reg...

Authors: Maria Dolors Ruiz Morilla, Mireia Sans, Albert Casasa and Nuria Giménez

ACSC Indicator: testing reliability for hypertension

With high-quality community-based primary care, hospitalizations for ambulatory care sensitive conditions (ACSC) are considered avoidable. The purpose of this study was to test the inter-physician reliability ...

Authors: Robin L. Walker, William A. Ghali, Guanmin Chen, Tej K. Khalsa, Birinder K. Mangat, Norm R. C. Campbell, Elijah Dixon, Doreen Rabi, Nathalie Jette, Robyn Dhanoa and Hude Quan

Development and testing of a mobile application to support diabetes self-management for people with newly diagnosed type 2 diabetes: a design thinking case study

Numerous mobile applications have been developed to support diabetes-self-management. However, the majority of these applications lack a theoretical foundation and the involvement of people with diabetes durin...

Authors: Mira Petersen and Nana F. Hempler

Perceptions on use of home telemonitoring in patients with long term conditions – concordance with the Health Information Technology Acceptance Model: a qualitative collective case study

Health information technology (HIT) may be used to improve care for increasing numbers of older people with long term conditions (LTCs) who make high demands on health and social care services. Despite its pot...

Authors: Jo B. Middlemass, Jolien Vos and A. Niroshan Siriwardena

Completeness and timeliness of notifiable disease reporting: a comparison of laboratory and provider reports submitted to a large county health department

Most public health agencies expect reporting of diseases to be initiated by hospital, laboratory or clinic staff even though so-called passive approaches are known to be burdensome for reporters and produce in...

Authors: Brian E. Dixon, Zuoyi Zhang, Patrick T. S. Lai, Uzay Kirbiyik, Jennifer Williams, Rebecca Hills, Debra Revere, P. Joseph Gibson and Shaun J. Grannis

Erratum to: Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data

Authors: J. A. Delgado-SanMartin, J. I. Hare, E. J. Davies and J. W. T. Yates

Using record linkage to validate notification and laboratory data for a more accurate assessment of notifiable infectious diseases

Infectious disease burden is commonly assessed using notification data. Using retrospective record linkage in Western Australia, we described how well notification data captures laboratory detections of influe...

Authors: Faye J. Lim, Christopher C. Blyth, Avram Levy, Parveen Fathima, Nicholas de Klerk, Carolien Giele and Hannah C. Moore

The challenges of emerging HISs in bridging the communication gaps among physicians and nurses in China: an interview study

To explore the current situation, existing problems and possible causes of said problems with regards to physician-nurse communication under an environment of increasingly widespread usage of Hospital Informat...

Authors: Dong Wen, Xingting Zhang, Jie Wan, Jing Fu and Jianbo Lei

Using multiclass classification to automate the identification of patient safety incident reports by type and severity

Approximately 10% of admissions to acute-care hospitals are associated with an adverse event. Analysis of incident reports helps to understand how and why incidents occur and can inform policy and practice for...

Authors: Ying Wang, Enrico Coiera, William Runciman and Farah Magrabi

Evaluating privacy-preserving record linkage using cryptographic long-term keys and multibit trees on large medical datasets

Integrating medical data using databases from different sources by record linkage is a powerful technique increasingly used in medical research. Under many jurisdictions, unique personal identifiers needed for...

Authors: Adrian P. Brown, Christian Borgs, Sean M. Randall and Rainer Schnell

Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development

Pharmacogenomic clinical decision support systems (CDSS) have the potential to help overcome some of the barriers for translating pharmacogenomic knowledge into clinical routine. Before developing a prototype ...

Authors: Marc Hinderer, Martin Boeker, Sebastian A. Wagner, Martin Lablans, Stephanie Newe, Jan L. Hülsemann, Michael Neumaier, Harald Binder, Harald Renz, Till Acker, Hans-Ulrich Prokosch and Martin Sedlmayr

CMOST: an open-source framework for the microsimulation of colorectal cancer screening strategies

Colorectal cancer (CRC) is a leading cause of cancer-related mortality. CRC incidence and mortality can be reduced by several screening strategies, including colonoscopy, but randomized CRC prevention trials f...

Authors: Meher K. Prakash, Brian Lang, Henriette Heinrich, Piero V. Valli, Peter Bauerfeind, Amnon Sonnenberg, Niko Beerenwinkel and Benjamin Misselwitz

The impact of a diagnostic decision support system on the consultation: perceptions of GPs and patients

Clinical decision support systems (DSS) aimed at supporting diagnosis are not widely used. This is mainly due to usability issues and lack of integration into clinical work and the electronic health record (EH...

Authors: Talya Porat, Brendan Delaney and Olga Kostopoulou

Implementation of eMental Health care: viewpoints from key informants from organizations and agencies with eHealth mandates

The use of technology such as computers, tablets, and smartphones to improve access to and the delivery of mental health care (eMental Health care) is growing worldwide. However, despite the rapidly expanding ...

Authors: Lori Wozney, Amanda S. Newton, Nicole D. Gehring, Kathryn Bennett, Anna Huguet, Lisa Hartling, Michele P. Dyson and Patrick McGrath

Multiscalar cellular automaton simulates in-vivo tumour-stroma patterns calibrated from in-vitro assay data

The tumour stroma -or tumour microenvironment- is an important constituent of solid cancers and it is thought to be one of the main obstacles to quantitative translation of drug activity between the preclinica...

Authors: J. A. Delgado-SanMartin, J. I. Hare, E. J. Davies and J. W. T. Yates

Bibliometric analysis of worldwide scientific literature in mobile - health: 2006–2016

The advancement of mobile technology had positively influenced healthcare services. An emerging subfield of mobile technology is mobile health (m-Health) in which mobile applications are used for health purpos...

Authors: Waleed M. Sweileh, Samah W. Al-Jabi, Adham S. AbuTaha, Sa’ed H. Zyoud, Fathi M. A. Anayah and Ansam F. Sawalha

Clinical decisions surrounding genomic and proteomic testing among United States veterans treated for lung cancer within the Veterans Health Administration

Current clinical guidelines recommend epidermal growth factor receptor (EGFR) mutational testing in patients with metastatic non-small cell lung cancer (NSCLC) to predict the benefit of the tyrosine kinase inh...

Authors: Olga Efimova, Brygida Berse, Daniel W. Denhalter, Scott L. DuVall, Kelly K. Filipski, Michael Icardi, Michael J. Kelley and Julie A. Lynch

Health care professionals’ attitudes towards evidence-based medicine in the workers’ compensation setting: a cohort study

Problems may arise during the approval process of treatment after a compensable work injury, which include excess paperwork, delays in approving services, disputes, and allegations of over-servicing. This is p...

Authors: Nieke A. Elbers, Robin Chase, Ashley Craig, Lyn Guy, Ian A. Harris, James W. Middleton, Michael K. Nicholas, Trudy Rebbeck, John Walsh, Simon Willcock, Keri Lockwood and Ian D Cameron