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  1. Understanding functions of proteins is one of the most important challenges in many studies of biological processes. The function of a protein can be predicted by analyzing the functions of structurally simila...

    Authors: Sungchul Kim, Lee Sael and Hwanjo Yu
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  2. Most previous Protein Protein Interaction (PPI) studies evaluated their algorithms' performance based on "per-instance" precision and recall, in which the instances of an interaction relation were evaluated in...

    Authors: Junkyu Lee, Seongsoon Kim, Sunwon Lee, Kyubum Lee and Jaewoo Kang
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  3. We consider the user task of designing clinical trial protocols and propose a method that discovers and outputs the most appropriate eligibility criteria from a potentially huge set of candidates. Each document d

    Authors: Angelo Restificar, Ioannis Korkontzelos and Sophia Ananiadou
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  4. Biological systems are robust and complex to maintain stable phenotypes under various conditions. In these systems, drugs reported the limited efficacy and unexpected side-effects. To remedy this situation, ma...

    Authors: Woochang Hwang, Yongdeuk Hwang, Sunjae Lee and Doheon Lee
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  5. Due to the low statistical power of individual markers from a genome-wide association study (GWAS), detecting causal single nucleotide polymorphisms (SNPs) for complex diseases is a challenge. SNP combinations...

    Authors: Chiyong Kang, Hyeji Yu and Gwan-Su Yi
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  6. Named entity recognition (NER) is an important task in clinical natural language processing (NLP) research. Machine learning (ML) based NER methods have shown good performance in recognizing entities in clinic...

    Authors: Buzhou Tang, Hongxin Cao, Yonghui Wu, Min Jiang and Hua Xu
    Citation: BMC Medical Informatics and Decision Making 2013 13(Suppl 1):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 13 Supplement 1

  7. Single Nucleotide Polymorphisms (SNPs) are sequence variations found in individuals at some specific points in the genomic sequence. As SNPs are highly conserved throughout evolution and within a population, t...

    Authors: Subrata Saha, Sanguthevar Rajasekaran, Jinbo Bi and Sudipta Pathak
    Citation: BMC Medical Informatics and Decision Making 2013 13:41
    Content type: Research article Published on:

  8. Little is known about the potential of syndromic surveillance to provide early warning of pertussis outbreaks. We conducted a time series analysis to assess whether an emergency department (ED) cough syndrome ...

    Authors: Aaron W Cashmore, David J Muscatello, Alistair Merrifield, Paula Spokes, Kristine Macartney and Bin B Jalaludin
    Citation: BMC Medical Informatics and Decision Making 2013 13:40
    Content type: Research article Published on:

  9. Multi-site health sciences research is becoming more common, as it enables investigation of rare outcomes and diseases and new healthcare innovations. Multi-site research usually involves the transfer of large...

    Authors: Christine E Bredfeldt, Amy Butani, Sandhyasree Padmanabhan, Paul Hitz and Roy Pardee
    Citation: BMC Medical Informatics and Decision Making 2013 13:39
    Content type: Research article Published on:

  10. Many children with asthma do not have sufficient asthma control, which leads to increased healthcare costs and productivity loss of parents. One of the causative factors are adherence problems. Effective inter...

    Authors: Erwin C Vasbinder, Hettie M Janssens, Maureen P M H Rutten-van Mölken, Liset van Dijk, Brenda C M de Winter, Ruben C A de Groot, Arnold G Vulto and Patricia M L A van den Bemt
    Citation: BMC Medical Informatics and Decision Making 2013 13:38
    Content type: Study protocol Published on:

  11. Computerized clinical trial recruitment support is one promising field for the application of routine care data for clinical research. The primary task here is to compare the eligibility criteria defined in tr...

    Authors: Felix Köpcke, Benjamin Trinczek, Raphael W Majeed, Björn Schreiweis, Joachim Wenk, Thomas Leusch, Thomas Ganslandt, Christian Ohmann, Björn Bergh, Rainer Röhrig, Martin Dugas and Hans-Ulrich Prokosch
    Citation: BMC Medical Informatics and Decision Making 2013 13:37
    Content type: Research article Published on:

  13. Cloud computing is a new paradigm that is changing how enterprises, institutions and people understand, perceive and use current software systems. With this paradigm, the organizations have no need to maintain...

    Authors: Jordi Vilaplana, Francesc Solsona, Francesc Abella, Rosa Filgueira and Josep Rius
    Citation: BMC Medical Informatics and Decision Making 2013 13:35
    Content type: Technical advance Published on:

  14. Chronic obstructive pulmonary disease (COPD) is associated with increased mortality and poor health-related quality of life (HRQoL) compared with the general population. The objective of this study was to iden...

    Authors: Olli-Pekka Ryynänen, Erkki J Soini, Ari Lindqvist, Maritta Kilpeläinen and Tarja Laitinen
    Citation: BMC Medical Informatics and Decision Making 2013 13:34
    Content type: Research article Published on:

  15. The prevalence of major chronic illnesses, such as chronic obstructive pulmonary disease (COPD) and diabetes, is increasing. Pulmonary rehabilitation and diabetes self-management education are important in the...

    Authors: Tatjana M Burkow, Lars K Vognild, Geir Østengen, Elin Johnsen, Marijke Jongsma Risberg, Astrid Bratvold, Tord Hagen, Morten Brattvoll, Trine Krogstad and Audhild Hjalmarsen
    Citation: BMC Medical Informatics and Decision Making 2013 13:33
    Content type: Research article Published on:

  16. Clinicians often encounter information about drug-drug interactions (DDIs) during clinical practice. This information is found within product information (hardcopy and electronic) and various electronic system...

    Authors: Edward P Armstrong, Sharon M Wang, Lisa E Hines, Sara Gao, Bimal V Patel and Daniel C Malone
    Citation: BMC Medical Informatics and Decision Making 2013 13:32
    Content type: Research article Published on:

  17. Despite the relatively huge ICT investment and policy deployment in higher institutions in Ethiopia, there is still scant information about the success of implementation of the Information Communication Techno...

    Authors: Solomon Assefa Woreta, Yigzaw Kebede and Desalegn Tegabu Zegeye
    Citation: BMC Medical Informatics and Decision Making 2013 13:31
    Content type: Research article Published on:

  18. Distinguishing cases from non-cases in free-text electronic medical records is an important initial step in observational epidemiological studies, but manual record validation is time-consuming and cumbersome....

    Authors: Zubair Afzal, Martijn J Schuemie, Jan C van Blijderveen, Elif F Sen, Miriam CJM Sturkenboom and Jan A Kors
    Citation: BMC Medical Informatics and Decision Making 2013 13:30
    Content type: Research article Published on:

  19. High levels of adherence to medications for HIV infection are essential for optimal clinical outcomes and to reduce viral transmission, but many patients do not achieve required levels. Clinician-delivered int...

    Authors: Raymond L Ownby, Drenna Waldrop-Valverde, Robin J Jacobs, Amarilis Acevedo and Joshua Caballero
    Citation: BMC Medical Informatics and Decision Making 2013 13:29
    Content type: Research article Published on:

  20. Accurate, timely and automated identification of patients at high risk for severe clinical deterioration using readily available clinical information in the electronic medical record (EMR) could inform health ...

    Authors: Carlos A Alvarez, Christopher A Clark, Song Zhang, Ethan A Halm, John J Shannon, Carlos E Girod, Lauren Cooper and Ruben Amarasingham
    Citation: BMC Medical Informatics and Decision Making 2013 13:28
    Content type: Research article Published on:

  21. Evidence informed decision making in health policy development and clinical practice depends on the availability of valid and reliable data. The introduction of interRAI assessment systems in many countries ha...

    Authors: John P Hirdes, Jeff W Poss, Hilary Caldarelli, Brant E Fries, John N Morris, Gary F Teare, Kristen Reidel and Norma Jutan
    Citation: BMC Medical Informatics and Decision Making 2013 13:27
    Content type: Research article Published on:

  22. To reduce the large public health burden of the high prevalence of depression, preventive interventions targeted at people at risk are essential and can be cost-effective. Web-based interventions are able to p...

    Authors: Saskia M Kelders, Wendy TM Pots, Maarten Jan Oskam, Ernst T Bohlmeijer and Julia EWC van Gemert-Pijnen
    Citation: BMC Medical Informatics and Decision Making 2013 13:26
    Content type: Research article Published on:

  23. There has been increasing emphasis on evidence-based approaches to improve patient outcomes through rigorous, standardised and well-validated approaches. Clinical guidelines drive this process and are largely ...

    Authors: Deborah Saltman, Debra Jackson, Phillip J Newton and Patricia M Davidson
    Citation: BMC Medical Informatics and Decision Making 2013 13:25
    Content type: Research article Published on:

  24. Type 2 diabetes is an increasingly common chronic condition whose prognosis can be improved by patient involvement and self-management. Patient involvement can be fostered by web-based Interactive Health Commu...

    Authors: Nina Weymann, Martin Härter and Jörg Dirmaier
    Citation: BMC Medical Informatics and Decision Making 2013 13:24
    Content type: Study protocol Published on:

  25. Smartphones and tablet computers have become an integral part of our lives. One of their key features is the possibility of installing third-party apps. These apps can be very helpful for improving health and ...

    Authors: Lex van Velsen, Desirée JMA Beaujean and Julia EWC van Gemert-Pijnen
    Citation: BMC Medical Informatics and Decision Making 2013 13:23
    Content type: Debate Published on:

  26. One area where the use of information and communication technology (ICT), or eHealth, could be developed is the home health care of premature infants. The aim of this randomized controlled study was to investi...

    Authors: Anna Gund, Bengt Arne Sjöqvist, Helena Wigert, Elisabet Hentz, Kaj Lindecrantz and Kristina Bry
    Citation: BMC Medical Informatics and Decision Making 2013 13:22
    Content type: Research article Published on:

  27. The rate of elective surgeries varies dramatically by geography in the United States. For many of these surgeries, there is not clear evidence of their relative merits over alternate treatment choices and ther...

    Authors: David R Veroff, Tamara Ochoa-Arvelo and Benjamin Venator
    Citation: BMC Medical Informatics and Decision Making 2013 13:21
    Content type: Research article Published on:

  28. In recent years, there have been numerous initiatives undertaken to describe critical information needs related to the collection, management, analysis, and dissemination of data in support of biomedical resea...

    Authors: Philip RO Payne, Taylor R Pressler, Indra Neil Sarkar and Yves Lussier
    Citation: BMC Medical Informatics and Decision Making 2013 13:20
    Content type: Research article Published on:

  29. A small pre-test study was conducted to ascertain potential harm and anxiety associated with distributing information about possible cancer treatment options at the time of biopsy, prior to knowledge about a d...

    Authors: Steven B Zeliadt, Peggy A Hannon, Ranak B Trivedi, Laura M Bonner, Thuy T Vu, Carol Simons, Crystal A Kimmie, Elaine Y Hu, Chris Zipperer and Daniel W Lin
    Citation: BMC Medical Informatics and Decision Making 2013 13:19
    Content type: Research article Published on:

  30. Symptoms of an adverse reaction to contrast agents for computed tomography are diverse ranging, and sometimes serious. The goal of this study is to create a scoring rule to predict adverse reactions to contras...

    Authors: Daiki Kobayashi, Osamu Takahashi, Takuya Ueda, Gautam A Deshpande, Hiroko Arioka and Tsuguya Fukui
    Citation: BMC Medical Informatics and Decision Making 2013 13:18
    Content type: Research article Published on:

  31. Developing Information and Communication Technology (ICT) supported health communication in PHC could contribute to increased health literacy and empowerment, which are foundations for enabling people to incre...

    Authors: Amina Jama Mahmud, Ewy Olander, Sara Eriksén and Bo JA Haglund
    Citation: BMC Medical Informatics and Decision Making 2013 13:17
    Content type: Research article Published on:

  33. Although information technology adequately supports clinical care in many intensive care units (ICUs), it provides much poorer support for the managerial information needed to coordinate multi-professional car...

    Authors: Heljä Lundgrén-Laine, Elina Kontio, Tommi Kauko, Heikki Korvenranta, Jari Forsström and Sanna Salanterä
    Citation: BMC Medical Informatics and Decision Making 2013 13:15
    Content type: Research article Published on:

  34. Preconception counseling is effective in reducing the risk of adverse pregnancy outcomes. The Internet is commonly used by women and health professionals to search for health information. We compared the consi...

    Authors: Eleonora Agricola, Francesco Gesualdo, Elisabetta Pandolfi, Michaela V Gonfiantini, Emanuela Carloni, Pierpaolo Mastroiacovo and Alberto E Tozzi
    Citation: BMC Medical Informatics and Decision Making 2013 13:14
    Content type: Research article Published on:

  35. The public healthcare sector in developing countries faces many challenges including weak healthcare systems and under-resourced facilities that deliver poor outcomes relative to total healthcare expenditure. ...

    Authors: Gregory B Cline and John M Luiz
    Citation: BMC Medical Informatics and Decision Making 2013 13:13
    Content type: Research article Published on:

  36. Detecting outbreaks is a crucial task for public health officials, yet gaps remain in the systematic evaluation of outbreak detection protocols. The authors’ objectives were to design, implement, and test a fl...

    Authors: Bryan Lewis, Stephen Eubank, Allyson M Abrams and Ken Kleinman
    Citation: BMC Medical Informatics and Decision Making 2013 13:12
    Content type: Technical advance Published on:

  37. The dual model approach represents a promising solution for achieving semantically interoperable standardized electronic health record (EHR) exchange. Its acceptance, however, will depend on the effort require...

    Authors: Georg Duftschmid, Judith Chaloupka and Christoph Rinner
    Citation: BMC Medical Informatics and Decision Making 2013 13:11
    Content type: Research article Published on:

  38. When a new drug is launched onto the market, information about the new manufactured product is contained in its monograph and evaluation report published by national drug agencies. Health professionals need to...

    Authors: Maia Iordatii, Alain Venot and Catherine Duclos
    Citation: BMC Medical Informatics and Decision Making 2013 13:10
    Content type: Research article Published on:

  39. The Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II) database is a free, public resource for intensive care research. The database was officially released in 2006, and has attracted a grow...

    Authors: Daniel J Scott, Joon Lee, Ikaro Silva, Shinhyuk Park, George B Moody, Leo A Celi and Roger G Mark
    Citation: BMC Medical Informatics and Decision Making 2013 13:9
    Content type: Software Published on:

  40. The practice of evidence-based medicine requires efficient biomedical literature search such as PubMed/MEDLINE. Retrieval performance relies highly on the efficient use of search field tags. The purpose of thi...

    Authors: Abu Saleh Mohammad Mosa and Illhoi Yoo
    Citation: BMC Medical Informatics and Decision Making 2013 13:8
    Content type: Research article Published on:

  41. In searches for clinical trials and systematic reviews, it is said that Google Scholar (GS) should never be used in isolation, but in addition to PubMed, Cochrane, and other trusted sources of information. We ...

    Authors: Jean-François Gehanno, Laetitia Rollin and Stefan Darmoni
    Citation: BMC Medical Informatics and Decision Making 2013 13:7
    Content type: Research article Published on:

  43. The valuable clinical data, specimens, and assay results collected during a primary clinical trial or observational study can enable researchers to answer additional, pressing questions with relatively small i...

    Authors: Elizabeth K Nelson, Britt Piehler, Adam Rauch, Sarah Ramsay, Drienna Holman, Smita Asare, Adam Asare and Mark Igra
    Citation: BMC Medical Informatics and Decision Making 2013 13:5
    Content type: Debate Published on:

  44. Since the beginning of 2007, the National Health Research Institutes has been promoting the dissemination of evidence-based medicine (EBM). The current study examined longitudinal trends of behaviors in how ho...

    Authors: Yi-Hao Weng, Ken N Kuo, Chun-Yuh Yang, Heng-Lien Lo, Ya-Hui Shih, Chiehfeng Chen and Ya-Wen Chiu
    Citation: BMC Medical Informatics and Decision Making 2013 13:4
    Content type: Research article Published on:

  45. Elective patient admission and assignment planning is an important task of the strategic and operational management of a hospital and early on became a central topic of clinical operations research. The manage...

    Authors: Robert Schmidt, Sandra Geisler and Cord Spreckelsen
    Citation: BMC Medical Informatics and Decision Making 2013 13:3
    Content type: Research article Published on:

  46. The rigorous elicitation of user needs is a crucial step for both medical device design and purchasing. However, user needs elicitation is often based on qualitative methods whose findings can be difficult to ...

    Authors: Leandro Pecchia, Jennifer L Martin, Angela Ragozzino, Carmela Vanzanella, Arturo Scognamiglio, Luciano Mirarchi and Stephen P Morgan
    Citation: BMC Medical Informatics and Decision Making 2013 13:2
    Content type: Research article Published on:

  47. Results of epidemiological studies linking census with mortality records may be affected by unlinked deaths and changes in cause of death classification. We examined these issues in the Swiss National Cohort (...

    Authors: Kurt Schmidlin, Kerri M Clough-Gorr, Adrian Spoerri, Matthias Egger and Marcel Zwahlen
    Citation: BMC Medical Informatics and Decision Making 2013 13:1
    Content type: Research article Published on:

  48. The purpose of this study is to develop and test reliability, validity, and utility of the Goal-Setting Evaluation Tool for Diabetes (GET-D). The effectiveness of diabetes self-management is predicated on goal...

    Authors: Cayla R Teal, Paul Haidet, Ajay S Balasubramanyam, Elisa Rodriguez and Aanand D Naik
    Citation: BMC Medical Informatics and Decision Making 2012 12:152
    Content type: Research article Published on:

  49. Secondary use of large scale administrative data is increasingly popular in health services and clinical research, where a user-friendly tool for data management is in great demand. MapReduce technology such a...

    Authors: Hiromasa Horiguchi, Hideo Yasunaga, Hideki Hashimoto and Kazuhiko Ohe
    Citation: BMC Medical Informatics and Decision Making 2012 12:151
    Content type: Software Published on:

  50. There are numerous applications for Health Information Systems (HIS) that support specific tasks in the clinical workflow. The Lean method has been used increasingly to optimize clinical workflows, by removing...

    Authors: Maryati Mohd Yusof, Soudabeh Khodambashi and Ariffin Marzuki Mokhtar
    Citation: BMC Medical Informatics and Decision Making 2012 12:150
    Content type: Research article Published on:
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