Skip to main content
Download PDF

Opportunities and challenges of virtual reality-based interventions for patients with breast cancer: a systematic review

BMC Medical Informatics and Decision Making volume 23, Article number: 17 (2023) Cite this article

Abstract

Background

Breast cancer is one of the most common cancers diagnosed worldwide and the second leading cause of death among women. Virtual reality (VR) has many opportunities and challenges for breast cancer patients' rehabilitation and symptom management. The purpose of this systematic review is to look into the benefits and drawbacks of VR interventions for breast cancer patients.

Methods

A systematic search was conducted on PubMed, Web of Science, Scopus, IEEE, and the Cochrane Library, from inception until February 6, 2022. The inclusion criteria were: (1) original studies without restriction in study design; (2) a study population consisting of patients with breast cancer; (3) any type of VR-based interventions (immersive and non-immersive); and (5) studies published in English. To assess the risk of bias, the Effective Public Health Practice Project (EPHPP) Tool was used.

Results

Eighteen articles were included in this systematic review. The result showed that VR could provide many opportunities for patients with breast cancer, including reducing anxiety, time perception, pain, fatigue, chemotherapy-related symptom distress levels, and depression severity, as well as improvement in the range of motion, strength, and function. Cybersickness symptoms, the weight of headsets and helmets, the quality of the visual image, and the cost of the equipment are some of the challenges in using this technology on these patients.

Conclusions

The systematic review showed that VR interventions have opportunities and challenges for patients with breast cancer. VR can be effective for rehabilitation and symptom management and is used in different stages of treatment to improve the condition of patients with breast cancer. However, before using it, the researcher should consider its challenges.

Peer Review reports

Introduction

Breast cancer is the second leading cause of death in women and one of the most common cancers diagnosed globally [1, 2]. Globally, over one million women have been diagnosed with breast cancer annually [3]. According to GLOBOCAN 2020, there were 2.3 million newly diagnosed cases in 2020, accounting for 11.7% of all newly diagnosed cancer cases. Furthermore, breast cancer is the fifth leading cause of cancer mortality worldwide, accounting for 685,000 deaths [2].

The main types of breast cancer treatment are surgery, radiation therapy (RT), chemotherapy (CT), endocrine therapy (ET), and targeted therapy [4]. Many breast cancer survivors experience physical and psychological symptoms (such as pain, fatigue, depression, anxiety, and lymphedema); functional deficits (such as reduced shoulder range of motion and cognitive impairment); emotional problems (such as fatigue, pain, anxiety, and depression); and other complications such as bleeding, effusion, and flap necrosis. Side effects from breast cancer or treatment can have a significant impact on the quality of life (QoL) of breast cancer survivors [5,6,7,8,9].

With recent technological advances, the development and application of modern technology in the healthcare field offer new non-invasive approaches to managing cancer-related symptoms, and their use brings new significant benefits [10, 11]. Virtual reality (VR) technology is a distraction method defined as a noninvasive simulation technology generated in a computer-generated image or environment with width, height, and depth dimensions. This technology allows users to interact with the virtual world [12]. Current VR systems include head-mounted devices (HMDs) with stereoscopic capabilities and additional devices such as body tracking sensors, headphones, and other input hardware such as data gloves and joysticks [13].

VR can be classified as immersive, semi-immersive, or non-immersive due to its sense of presence and level of immersion. Immersive is obtained using an HMD that blocks the view of the external environment and allows the user to immerse in a three-dimensional virtual environment. In non-immersive VR, subjects interact with a scenario displayed on a screen (computer, mobile, tablet, TV) or a wall in front of a person but do not become fully immersed because they can perceive the real world together with digital images. A semi-immersive experience is something in between immersive and non-immersive VR. It takes the subjects to a partially immersive scenario displayed on a screen, and frequently they can interact with the digital scene through body movements [14, 15].

In recent years, VR has become popular in clinical research studies and used in the cancer field [7, 16, 17]. VR is a distraction intervention that can relieve symptoms such as pain, stress, anxiety, depression, fatigue, nausea, and others [18]. Most studies have shown that VR can play an essential role in patients’ empowerment and education, rehabilitation, management of cancer-related symptoms, psychiatric disorders, and side effects from treatment [7, 9, 11, 19,20,21]. However, this technology has drawbacks such as cybersickness, discomfort, user resistance, equipment cost, and others [22,23,24].

Although systematic reviews have been conducted to examine the effectiveness of VR-based interventions in the rehabilitation management of patients with breast cancer [9, 25, 26], our systematic review compared them and found some differences. In this study, we focused on both rehabilitation and symptom management of patients with breast cancer. We examined all the opportunities and benefits of using VR technology, from the mental and physical aspects it can have on breast cancer patients. Furthermore, we investigated the challenges of using this technology as well as the limitations of previous studies in this field that were not mentioned in previous reviews.

Therefore, the present study was conducted to answer the following questions: (1) What are the opportunities for VR interventions for patients with breast cancer? (2) What are the challenges, limitations and obstacles of VR interventions for patients with breast cancer? (3) What is the type of VR application (immersive or non-immersive) for patients with breast cancer? (4) In which stage of treatment was VR used? (5) What are the outcomes of using VR in breast cancer?

Methods

Overview

The current systematic review followed the Preferred Reporting Items on Systematic Reviews and Meta-analysis (PRISMA) guidelines [27].

Search strategy

A systematic search was conducted using the following databases: Medline (through PubMed), Web of Science, Scopus, IEEE, and the Cochrane Library. These databases were searched from inception to 6 February 2022 for select relevant articles. Medical Subject Headings (MeSH) were used to determine the keywords. The keywords used for the search included “virtual reality”, and “breast cancer”. Mesh terms and related keywords are presented in Table 1. We reviewed the reference list of included articles to identify articles missed in the database search.

Table 1 Search strategy for PubMed database
Full size table

Selection criteria

Based on the following inclusion and exclusion criteria, a decision was made regarding including studies in this systematic review:

The inclusion criteria were (1) original studies without restriction in study design, (2) study population consisting of patients with breast cancer, (3) studies published in English language, (4) any type of VR technology (immersive or non-immersive).

Exclusion criteria were (1) reviews, meta-analyses, conference abstract, commentaries, editorials, protocols, expert opinions, and letter to editor, (2) full text not published in English, (3) unavailability of full text for data extraction, (4) studies unrelated to the purpose of the research, (5) duplicate studies, and (6) used any interventions rather than VR.

Study selection

All studies identified were imported into EndNote X9 citation management software (Thomson Reuters, Toronto, Ontario, Canada). After removing duplicates, three authors (Alireza Banaye Yazdipour (ABY), Soheila Saeedi (SS), and Hassan Bostan (HB)) independently screened the titles and abstracts of all studies identified by the search criteria. Full texts of the remaining relevant studies were obtained, and three authors (ABY, SS, and HB) read the full-text papers and made a final selection of relevant studies. Reference lists were screened for additional eligible studies. Any disagreements were resolved by discussion and consensus between the authors and Marjan Ghazisaeedi (MG). Full-text of reviewed articles that did not meet inclusion criteria were removed, and reasons for exclusion were noted.

Data extraction

Three reviewers performed data extraction independently (ABY, SS, and HB) using a designed form in Microsoft Excel. Any disagreement was resolved through discussion with MG. The extracted data consisted of the first author, publication year, journal or conference name, country, study design, platform, aim, type of VR application, sample size, sample description, session details, stage of treatment, type of VR technology, challenges of using VR, opportunities of using VR, limitations of the study, and outcomes.

Quality assessment

The quality of the included studies was assessed using the “Quality Assessment Tool for Quantitative Studies” developed by the Effective Public Health Practice Project (EPHPP) [28]. This tool contains six components: (1) selection bias; (2) study design; (3) control for confounders; (4) blinding of participants and study staff; (5) validity and reliability of the data collection tools, and 6) withdrawals and drop-outs. Each component was rated as “weak”, “moderate”, or “strong” based on standardized criteria. A global rating for each study is calculated as: ‘strong’ = no weak subscale ratings; ‘moderate’ = one weak subscale rating; ‘weak’ = two or more weak subscale ratings. Each study that met inclusion criteria was assessed independently by three researchers (ABY, SS, HB). Any discrepancies were resolved by discussion and consensus between the authors and MG.

Data analysis

The results of this study were reported descriptively, and due to the diverse outcomes and results, no meta-analysis was performed. We categorized studies that used HMD for VR intervention as immersive, while studies that didn’t use HMD were non-immersive. We categorized the limitations of the reviewed studies into two general categories: limitations related to VR technology and limitations related to the type of studies. We also divided the study's opportunities into three broad categories: no effect, positive effect, and negative effect. For studies in which statistical analysis was performed, we considered the statistically significant outcome in the intervention group as a positive effect. Furthermore, in studies in which statistical analysis was not performed, we considered the outcome that increased in the intervention group compared to the control group to be a positive effect. The authors of this study analyzed these outcomes based on deductions from the results and discussion of included studies. The VOSviewer software (version1.6.18, www.vosviewer.com) was used to identify the occurrence of keywords.

Results

Search output

A total of 1143 potentially relevant articles were initially identified from the five databases; 120 articles were removed due to duplication, and the remaining 1023 studies were screened. We excluded 974 articles due to low relevance based on the title and abstract, and 49 full-text articles were screened. The characteristics of the excluded studies are shown in the PRISMA diagram. After all the eligibility criteria were applied, 16 articles were included. Two additional articles were identified by manually searching the reference lists of included articles. These two studies met our inclusion criteria. Finally, eighteen articles were included in the systematic review (Fig. 1).

Fig. 1
figure 1

PRISMA flow diagram indicating results of identification and screening process for included and excluded papers

Full size image

Characteristics of the included studies

The characteristics of the 18 studies are shown in Table 2. The oldest and newest studies were published in 2003 and 2021, respectively. Study designs in most of the studies were before-after (N = 5) (19, 29,30,31,32), cross-over (N = 5) [33,34,35,36,37], and RCT (N = 4) [7, 20, 38, 39]. Other study designs in reviewed articles were cross-sectional [40], experimental design [41], quasi-experimental [42] and quasi-randomized clinical trials [43], each with one study. All participants were adult patients with breast cancer. The type of VR technology in 9 studies (50%) mentioned that was immersive. The minimum sample size of patients was 2, and the maximum sample size of patients was 137 (IQR1: 16, median: 36.5, IQR3: 52). The intervention duration varied from 7 to 90 min.

Table 2 Characteristics of the 18 studies
Full size table

Figure 2 shows six studies from the United States [30, 33,34,35,36,37], four from Italy [7, 31, 40, 44], and one from Australia [42], Brazil [29], China [41], Egypt [43], France [19], Jordan [20], Poland [32], and Turkey [38].

Fig. 2
figure 2

The distribution of studies based on their conducted countries

Full size image

Figure 3 shows that most studies are published in journals (15 of 18 studies; 83.3%) and between 2016 to 2021 (13 of 18; 72.2%).

Fig. 3
figure 3

The distribution of studies based on publication year and type

Full size image

Figure 4 shows that most VR intervention platforms were computer-based with HMD (7 of 18 studies; 38.8%). In 4 of 18 studies (22.2%), VR intervention platforms were computer-based without HMD.

Fig. 4
figure 4

The radar chart of the platforms used for VR intervention

Full size image

Figure 5 shows VOSviewer's overlay visualization of keyword co-occurrence. Each node in the network represents a keyword, and the size of the circle indicates the occurrence frequency. The distance between these keywords on the VOSviewer map reveals the relationship between these keywords. The more the two keywords appear together, the closer they are to the network. Larger circles representing keywords such as breast cancer, breast tumors, and tumors indicated that these keywords appeared more frequently. VR is closer to breast cancer and breast tumors, which indicates the importance of VR interventions in this field.

Fig. 5
figure 5

Co-occurrence overlay visualization network of keywords

Full size image

Challenges and limitations of included studies

The challenges and limitations of included studies were classified into two categories: VR and study-related (Table 3).

Table 3 Challenges and limitations of included studies
Full size table

Challenges and limitations of VR-related

Most of the challenges and limitations in the VR category were 1) the weight of headsets and helmets and 2) User resistance because of first exposure to the VR.

Challenges and limitations of study-related

In the study category, most of the challenges and limitations were 1) small sample size, 2) study design, 3) single study site, 4) lack of generalizability, and 5) risk of bias.

Outcomes and opportunities of VR intervention

Table 4 presents the outcomes and opportunities of VR intervention in breast cancer use. The outcomes and opportunities of VR in included studies are classified into two categories: mental and physical.

Table 4 Outcomes of VR intervention in included studies
Full size table

Mental outcomes

The mental aspects of outcomes related to VR intervention mentioned in the studies included reducing anxiety, time perception, pain, chemotherapy-related symptom distress levels, fatigue, depression severity, and other. The most positive mental effects were related to the three subgroups, such as reducing anxiety and time perception (five studies), reducing pain (four studies), reducing chemotherapy-related symptom distress levels, and fatigue (three studies).

Physical outcomes

The physical aspects of outcomes related to VR intervention mentioned in the studies included improving the strength and function metrics, increasing the range of motion metrics, reducing heart rate and blood pressure, and other. The most positive physical effects were related to the three subgroups, such as improving the strength and function metrics, reducing fatigue (three studies) and increasing the range of motion metrics (two studies).

Quality assessment of the included studies

The results of the quality assessment are shown in Fig. 6. Based on the sum of scores, most studies were strong in terms of drop-outs and data collection (94%), and moderate in terms of blinding (78%). Concerning the global rating score, 56% of the included studies were strong, 33% moderate, and 11% weak.

Fig. 6
figure 6

Quality assessment of the included studies

Full size image

Discussion

This systematic review examined the opportunities and challenges of VR intervention in patients with breast cancer and discussed the opportunities, challenges, and positive and negative effects of its mental and physical aspects. The most important benefits and opportunities of using VR from a mental perspective in this group of patients were that it reduced anxiety and pain and led patients to underestimate the time spent during treatment using VR technology compared to the duration of the treatment without this technology. In a systematic review, Chow et al. found that the VR was an effective distraction for reducing pain and anxiety for patients with cancer undergoing medical interventions or receiving chemotherapy. The findings of this systematic review are congruent with previous reviews. They show that VR intervention can effectively manage mental aspects such as anxiety, time perception, pain, fatigue, and depression severity [45,46,47,48]. Based on the distraction mechanism in adult and pediatric cancer patients at various stages, the possible reason for the effectiveness of VR intervention in managing mental aspects can be considered [49,50,51]. Schneider et al., in their studies, found that VR can reduce anxiety in patients undergoing chemotherapy. In addition, patients undergoing chemotherapy suggested that anxiety was reduced primarily by an altered perception of time, a sense of fun and enjoyment, and astonishment that the session had been completed [34, 35]. However, potential factors that may have influenced the results must be investigated and taken into account for future research.

This technology also had several physical benefits for patients, such as improving function metrics and increasing the range of motion metrics. VR technology may increase individuals' motivation and participation in treatment programs. In addition, they are allowing a wide range of possible movements and exercises to be implemented in rehabilitation programs. A systematic review by de Araújo et al. showed that VR-based interventions in different rehabilitation protocols improved motor function, balance, aerobic function, driving skills, pain level, and psychological and motivational aspects [52]. Most studies found that VR intervention can be effective in upper limb rehabilitation and improve physical aspects such as strength and function metrics and range of motion metrics [48, 53,54,55], consistent with our findings. Quality of life (QoL) is related to the level of physical activity. Therefore, physical exercise programs are used to rehabilitate patients treated with chemotherapy. VR interventions could help improve the level of physical activity and QoL.

Cybersickness symptoms were not reported in most studies for using VR in breast cancer patients' treatment, which indicates that technology is advancing to the point where cybersickness symptoms are no longer evident. The findings of this systematic review are in line with previous studies [9, 48]. Cybersickness refers to symptoms and unpleasant side effects that users experience during or after VR immersion, such as nausea, headache, dizziness, vomiting, eyestrain, tiredness, disorientation, ataxia, pallor, dry mouth, and sweating [56, 57]. Chirico et al. in their study reported cybersickness symptoms using the Virtual Reality Symptom Questionnaire (VRSQ) [58]. Their findings showed that except for a slight difficulty in concentrating, all symptoms such as nausea, dizziness, headache, drowsiness, and eyestrain occurred with a frequency of less than 20% in the patients [7]. In a systematic review and meta-analysis, Caserman et al. found that advancements in technology and current-generation VR HMDs have significantly fewer problems with cybersickness (P < 0.001), which could be due to technological advances. However, some symptoms of cybersickness are still present. Furthermore, they discovered that the nature of movement, specifically sensory mismatch and perceived motion, were the primary causes of cybersickness in VR [57].

This systematic review indicated that VR had negative effects in only two studies, including cybersickness in one study and no reduction in pain in another. Our study revealed that the application of VR may always bring challenges. The most critical challenges reported in studies related to this technology include two challenges: (1) the weight of headsets and helmets; and (2) the resistance of patients affected by breast cancer against using VR because of their first exposure to it. User resistance is a complex behavior phenomenon that is considered as an important constraint in the successful implementation and use of technology [59]. When a new technology such as VR is used for the first time, patients may resist using it due to a lack of familiarity and fear use it [60]. However, more studies are necessary about the resistance of patients affected by breast cancer against using VR.

Safi et al. in their study found that engaging and supporting stakeholders in developing new technologies such as VR is essential and can reduce user resistance, which leads to increased technology acceptance in individuals [61]. As a result, it is suggested that patients receive the necessary education to become acquainted with emerging technologies such as VR.

This study showed that therapists could use VR in different stages of treatment to improve the condition of patients with breast cancer. As mentioned, VR can be used in chemotherapy, radiotherapy, and the post-surgery period, and therapists can achieve different goals with this technology in these stages of treatment. For example, they can be used in patients who have had a mastectomy to increase their range of motion. In the chemotherapy stage, it can also be employed to reduce time perception, which many studies have shown that it was instrumental in this goal and has led to less understanding of the time spent. On the other hand, this technology can be utilized to reduce fatigue or even depression in these patients. The findings of this systematic review are consistent with previous reviews on this topic [9, 48, 50]. VR intervention appears to be a powerful and effective tool for diverting patients' attention away from medical procedures such as chemotherapy [50].

This study had a series of strengths and limitations. One of the strengths of this study was searching five valid databases and examining the references of all the included studies, which led to including the most relevant studies in this review as much as possible. However, this study has some limitations that need to be addressed. Firstly, the number of trials was small. Secondly, the included studies involved small sample sizes, highlighting the need to develop trials with larger population sizes. Thirdly, studies in non-English languages should also be considered.

Implication for practice and future research

The results of this systematic review demonstrated that using VR intervention in breast cancer patients decreases anxiety, pain, depression, fatigue, time perception, fear of movement, and cognition function. In addition, the technology increases relaxation, knowledge, confidence, satisfaction, strength and function metrics, and range of motion metrics. Moreover, cybersickness symptoms were rare, and this reflects the advancement of VR technology. Based on these findings, it is recommended that healthcare providers use VR intervention for patients with breast cancer during the care process, chemotherapy, radiation therapy, and after surgery. The development of VR programs that empower patients to continue their therapy at home can be helpful because the treatment does not end when the patient leaves the oncology ward. Future studies can be conducted with larger sample size, longer intervention duration, and higher methodological quality. Furthermore, it is suggested that this intervention's cybersickness symptoms and cost-effectiveness be examined.

Conclusion

This systematic review showed that VR interventions could serve as a tool for supporting breast cancer patients. VR could provide opportunities to reduce anxiety, time perception, pain, fatigue, chemotherapy-related symptom distress levels, and depression severity and improve the range of motion, strength, and function. However, some challenges include the weight of headsets and helmets, visual image quality, and equipment cost. VR can be effective for rehabilitation and symptom management and is used in different stages of treatment to improve the condition of patients with breast cancer. However, cybersickness’s clinical factors are poorly understood and need further research.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Abbreviations

VR:

Virtual Reality

QoL:

Quality of Life

HMD:

Head-Mounted Display

RT:

Radiation Therapy

MT:

Music Therapy

ROM:

Range of Motion

BC:

Breast Cancer

PNF:

Proprioceptive Neuromuscular Facilitation

References

  1. Sethy PK, Behera SK. Automatic classification with concatenation of deep and handcrafted features of histological images for breast carcinoma diagnosis. Multimed Tools Appl. 2022;6:89.

    Google Scholar 

  2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71(3):209–49.

    Article  Google Scholar 

  3. Yi M, Li T, Niu M, Luo S, Chu Q, Wu K. Epidemiological trends of women’s cancers from 1990 to 2019 at the global, regional, and national levels: a population-based study. Biomarker Res. 2021;9(1):55.

    Article  Google Scholar 

  4. Zhang Y, Li H, Zhang J, Zhao C, Lu S, Qiao J, et al. The combinatory effects of natural products and chemotherapy drugs and their mechanisms in breast cancer treatment. Phytochem Rev. 2020;19(5):1179–97.

    Article  CAS  Google Scholar 

  5. Wei D, Liu X-Y, Chen Y-Y, Zhou X, Hu H-P. Effectiveness of physical, psychological, social, and spiritual intervention in breast cancer survivors: an integrative review. Asia Pac J Oncol Nurs. 2016;3(3):226–32.

    Article  Google Scholar 

  6. Lovelace DL, McDaniel LR, Golden D. Long-term effects of breast cancer surgery, treatment, and survivor care. J Midwifery Womens Health. 2019;64(6):713–24.

    Article  Google Scholar 

  7. Chirico A, Maiorano P, Indovina P, Milanese C, Giordano GG, Alivernini F, et al. Virtual reality and music therapy as distraction interventions to alleviate anxiety and improve mood states in breast cancer patients during chemotherapy. J Cell Physiol. 2020;235(6):5353–62.

    Article  CAS  Google Scholar 

  8. El Beheiry M, Gaillard T, Girard N, Darrigues L, Osdoit M, Feron JG, et al. Breast magnetic resonance image analysis for surgeons using virtual reality: a comparative study. JCO Clin Cancer Inform. 2021;5:1127–33.

    Article  Google Scholar 

  9. Bu X, Ng PHF, Xu W, Cheng Q, Chen PQ, Cheng ASK, et al. The effectiveness of virtual reality-based interventions in rehabilitation management of breast cancer survivors: systematic review and meta-analysis. JMIR Ser Games. 2022;10(1):e31395.

    Article  Google Scholar 

  10. Chirico A, Lucidi F, De Laurentiis M, Milanese C, Napoli A, Giordano A. Virtual reality in health system: beyond entertainment. A mini-review on the efficacy of VR during cancer treatment. J Cell Physiol. 2016;231(2):275–87.

    Article  CAS  Google Scholar 

  11. Zeng Y, Zhang J-E, Cheng ASK, Cheng H, Wefel JS. Meta-analysis of the efficacy of virtual reality-based interventions in cancer-related symptom management. Integr Cancer Ther. 2019;18:1534735419871108.

    Article  Google Scholar 

  12. Moskaliuk J, Kimmerle J, Cress U. Virtual reality 2.0 and its application in knowledge building. In: Murugesan S, editor. Handbook of research on web 20, 30, and X0: technologies, business, and social applications. Hershey: IGI Global; 2010. p. 573–92.

    Google Scholar 

  13. Li L, Yu F, Shi D, Shi J, Tian Z, Yang J, et al. Application of virtual reality technology in clinical medicine. Am J Transl Res. 2017;9(9):3867–80.

    Google Scholar 

  14. Mujber TS, Szecsi T, Hashmi MSJ. Virtual reality applications in manufacturing process simulation. J Mater Process Technol. 2004;155–156:1834–8.

    Article  Google Scholar 

  15. Bamodu O, Ye XM. Virtual reality and virtual reality system components. Adv Mater Res. 2013;765:1169–72.

    Article  Google Scholar 

  16. Feyzioglu O, Dincer S, Akan A, Algun ZC. Is Xbox 360 Kinect-based virtual reality training as effective as standard physiotherapy in patients undergoing breast cancer surgery? Support Care Cancer. 2020;28(9):4295–303.

    Article  Google Scholar 

  17. Jimenez YA, Cumming S, Wang W, Stuart K, Thwaites DI, Lewis SJ. Patient education using virtual reality increases knowledge and positive experience for breast cancer patients undergoing radiation therapy. Supp Care Cancer. 2018;26(8):2879–88.

    Article  Google Scholar 

  18. Menekli T, Yaprak B, Doğan R. The effect of virtual reality distraction intervention on pain, anxiety, and vital signs of oncology patients undergoing port catheter implantation: a randomized controlled study. Pain Manag Nurs. 2022;5:89.

    Google Scholar 

  19. Buche H, Michel A, Piccoli C, Blanc N. Contemplating or acting? which immersive modes should be favored in virtual reality during physiotherapy for breast cancer. Rehabilitation. 2021;9:12.

    Google Scholar 

  20. Bani Mohammad E, Ahmad M. Virtual reality as a distraction technique for pain and anxiety among patients with breast cancer: a randomized control trial. Palliat Supp Care. 2019;17(1):29–34.

    Article  Google Scholar 

  21. Cieślik B, Mazurek J, Rutkowski S, Kiper P, Turolla A, Szczepańska-Gieracha J. Virtual reality in psychiatric disorders: a systematic review of reviews. Complement Ther Med. 2020;52:102480.

    Article  Google Scholar 

  22. Tian N, Lopes P, Boulic R. A review of cybersickness in head-mounted displays: raising attention to individual susceptibility. Virtual Reality. 2022;5:79.

    Google Scholar 

  23. Ciccone BA, Bailey SKT, Lewis JE. The next generation of virtual reality: recommendations for accessible and ergonomic design. Ergon Des. 2021;5:10648046211002578.

    Google Scholar 

  24. Yan Y, Chen K, Xie Y, Song Y, Liu Y, editors. The effects of weight on comfort of virtual reality devices. Advances in ergonomics in design. Cham: Springer; 2019.

    Google Scholar 

  25. Zasadzka E, Pieczyńska A, Trzmiel T, Hojan K. Virtual reality as a promising tool supporting oncological treatment in breast cancer. Palliat Supp Care. 2021;18(16):8768.

    Google Scholar 

  26. Tian Q, Xu M, Yu L, Yang S, Zhang W. The efficacy of virtual reality-based interventions in breast cancer-related symptom management: a systematic review and meta-analysis. Cancer Nurs. 2015;9:900.

    Google Scholar 

  27. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–12.

    Article  Google Scholar 

  28. Pompeu-Robinson A, Kunz M, Falkson CB, Schreiner LJ, Joshi CP, Fichtinger G. Immobilization and catheter guidance for breast brachytherapy. Int J Comput Assist Radiol Surg. 2012;7(1):65–72.

    Article  CAS  Google Scholar 

  29. Camargo C, Cavalheiro G, Cardoso A, Lamounier E, Andrade AO, Mendes I, et al., editors. Virtual rehabilitation in women with post breast cancer-A case study. In 2013 International Conference on Virtual Rehabilitation (ICVR); 2013.

  30. House G, Burdea G, Grampurohit N, Polistico K, Roll D, Damiani F, et al. A feasibility study to determine the benefits of upper extremity virtual rehabilitation therapy for coping with chronic pain post-cancer surgery. Br J Pain. 2016;10(4):186–97.

    Article  Google Scholar 

  31. Melillo A, Chirico A, De Pietro G, Gallo L, Caggianese G, Barone D, et al. Virtual reality rehabilitation systems for cancer survivors: a narrative review of the literature. Cancers. 2022;14(13):6.

    Article  Google Scholar 

  32. Piejko L, Niewolak K, Fielek D, Pecyna P, Chełminiak D, Zieliński P, et al. Medical resort treatment extended with modern feedback exercises using virtual reality improve postural control in breast cancer survivors. Preliminary Study. 2020;62:92–8.

    Google Scholar 

  33. Schneider SM, Ellis M, Coombs WT, Shonkwiler EL, Folsom LC. Virtual reality intervention for older women with breast cancer. Cyberpsychol Behav. 2003;6(3):301–7.

    Article  Google Scholar 

  34. Schneider SM, Prince-Paul M, Allen MJ, Silverman P, Talaba D. Virtual reality as a distraction intervention for women receiving chemotherapy. Oncol Nurs Forum. 2004;31(1):81–8.

    Article  Google Scholar 

  35. Schneider SM, Hood LE. Virtual reality: a distraction intervention for chemotherapy. Oncol Nurs Forum. 2007;34(1):39–46.

    Article  Google Scholar 

  36. Schneider SM, Kisby CK, Flint EP. Effect of virtual reality on time perception in patients receiving chemotherapy. Support Care Cancer. 2011;19(4):555–64.

    Article  Google Scholar 

  37. Ashley VL, McNamara A, Xu X, Stubbins R. Effects of virtual reality v. biophilic environments on pain and distress in oncology patients: a case-crossover pilot study. Sci Rep. 2021;11(1):20196.

    Article  Google Scholar 

  38. Feyzioğlu Ö, Dinçer S, Akan A, Algun ZC. Is Xbox 360 Kinect-based virtual reality training as effective as standard physiotherapy in patients undergoing breast cancer surgery? Supp Care Cancer. 2020;28(9):4295–303.

    Article  Google Scholar 

  39. Chirico A, D’Aiuto M, Pinto M, Milanese C, Napoli A, Avino F, et al editors. The elapsed time during a virtual reality treatment for stressful procedures. A pool analysis on breast cancer patients during chemotherapy. Intelligent interactive multimedia systems and services. Cham: Springer; 2016.

    Google Scholar 

  40. Durosini I, Triberti S, Pravettoni G. Breast cancer survivors’ attitudes towards internet-based psychotherapy. Annu Rev Cyberther Telemed. 2020;18:201–5.

    Google Scholar 

  41. Zhou Z, Li J, Wang H, Luan Z, Li Y, Peng X. Upper limb rehabilitation system based on virtual reality for breast cancer patients: development and usability study. PLoS ONE. 2021;16(12):e0261220.

    Article  CAS  Google Scholar 

  42. Jimenez YA, Cumming S, Wang W, Stuart K, Thwaites DI, Lewis SJ. Patient education using virtual reality increases knowledge and positive experience for breast cancer patients undergoing radiation therapy. Supp Care Cancer. 2018;26(8):2879–88.

    Article  Google Scholar 

  43. Atef D, Elkeblawy MM, El-Sebaie A, Abouelnaga WAI. A quasi-randomized clinical trial: virtual reality versus proprioceptive neuromuscular facilitation for postmastectomy lymphedema. J Egypt Natl Canc Inst. 2020;32(1):29.

    Article  Google Scholar 

  44. Zhang L. Evaluation of incision margin and radiotherapy adjustment in breast cancer-conserving surgery based on VR pathology 3D reconstruction. J Healthcare Eng. 2021;2021:2709461.

    Google Scholar 

  45. Ahmad M, Bani Mohammad E, Anshasi HA. Virtual reality technology for pain and anxiety management among patients with cancer: a systematic review. Pain Manag Nurs. 2020;21(6):601–7.

    Article  Google Scholar 

  46. Chow H, Hon J, Chua W, Chuan A. Effect of virtual reality therapy in reducing pain and anxiety for cancer-related medical procedures: a systematic narrative review. J Pain Symptom Manag. 2021;61(2):384–94.

    Article  Google Scholar 

  47. Ioannou A, Papastavrou E, Avraamides MN, Charalambous A. Virtual reality and symptoms management of anxiety, depression, fatigue, and pain: a systematic review. SAGE Open Nurs. 2020;6:2377960820936163.

    Google Scholar 

  48. Tian Q, Xu M, Yu L, Yang S, Zhang W. The efficacy of virtual reality-based interventions in breast cancer-related symptom management: a systematic review and meta-analysis. Cancer Nurs. 2022;9:78.

    Google Scholar 

  49. Sajeev MF, Kelada L, Yahya NAB, Wakefield CE, Wewege MA, Karpelowsky J, et al. Interactive video games to reduce paediatric procedural pain and anxiety: a systematic review and meta-analysis. Br J Anaes. 2021;127(4):608–19.

    Article  Google Scholar 

  50. Rutkowski S, Czech O, Wrzeciono A, Kiper P, Szczepańska-Gieracha J, Malicka I. Virtual reality as a chemotherapy support in treatment of anxiety and fatigue in patients with cancer: a systematic review and meta-analysis and future research directions. Complement Ther Med. 2021;61: 102767.

    Article  Google Scholar 

  51. Slater M, Banakou D, Beacco A, Gallego J, Macia-Varela F, Oliva R. A separate reality: an update on place illusion and plausibility in virtual reality. Front Virtual Real. 2022;3:914392.

    Article  Google Scholar 

  52. de Araújo AVL, Neiva JFO, Monteiro CBM. Efficacy of virtual reality rehabilitation after spinal cord injury: a systematic review. BioMed Res Int. 2019;2019:7106951.

    Article  Google Scholar 

  53. De Miguel-Rubio A, Rubio MD, Alba-Rueda A, Salazar A, Moral-Munoz JA, Lucena-Anton D. Virtual reality systems for upper limb motor function recovery in patients with spinal cord injury: systematic review and meta-analysis. JMIR Mhealth Uhealth. 2020;8(12):e22537.

    Article  Google Scholar 

  54. Melillo A, Chirico A, De Pietro G, Gallo L, Caggianese G, Barone D, et al. Virtual reality rehabilitation systems for cancer survivors: a narrative review of the literature. Cancers. 2022;14(13):3163.

    Article  CAS  Google Scholar 

  55. Aminov A, Rogers JM, Middleton S, Caeyenberghs K, Wilson PH. What do randomized controlled trials say about virtual rehabilitation in stroke? A systematic literature review and meta-analysis of upper-limb and cognitive outcomes. J Neuroeng Rehabil. 2018;15(1):29.

    Article  Google Scholar 

  56. Weech S, Kenny S, Barnett-Cowan M. Presence and cybersickness in virtual reality are negatively related: a review. Front Psychol. 2019;5:10.

    Google Scholar 

  57. Caserman P, Garcia-Agundez A, Gámez Zerban A, Göbel S. Cybersickness in current-generation virtual reality head-mounted displays: systematic review and outlook. Virtual Reality. 2021;25(4):1153–70.

    Article  Google Scholar 

  58. Ames SL, Wolffsohn JS, McBrien NA. The development of a symptom questionnaire for assessing virtual reality viewing using a head-mounted display. Opt Vis Sci. 2005;82(3):74.

    Article  Google Scholar 

  59. Ali M, Zhou L, Miller L, Ieromonachou P. User resistance in IT: a literature review. Int J Inf Manag. 2016;36(1):35–43.

    Article  Google Scholar 

  60. Samhan B, Joshi KD, editors. Resistance of Healthcare Information Technologies; Literature Review, Analysis, and Gaps. In 2015 48th Hawaii International Conference on System Sciences; 2015.

  61. Safi S, Thiessen T, Schmailzl KJG. Acceptance and resistance of new digital technologies in medicine: qualitative study. JMIR Res Protoc. 2018;7(12):e11072.

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank all the participants in the study.

Funding

No Funding.

Author information

Authors and Affiliations

  1. Department of Health Information Management and Medical Informatics, School of Allied Medical Sciences, Tehran University of Medical Sciences, 3th Floor, No #17, Farredanesh Alley, Ghods St, Enghelab Ave, Tehran, Iran

    Alireza Banaye Yazdipour, Soheila Saeedi, Hassan Bostan, Hoorie Masoorian, Hasan Sajjadi & Marjan Ghazisaeedi

  2. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

    Alireza Banaye Yazdipour

  3. Clinical Research Development Unit of Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Soheila Saeedi

  4. Abadan University of Medical Sciences, Abadan, Iran

    Hassan Bostan

Authors
  1. Alireza Banaye Yazdipour
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Soheila Saeedi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hassan Bostan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hoorie Masoorian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hasan Sajjadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marjan Ghazisaeedi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

ABY, MG and HS conceived the idea for the review. ABY, SS, and MG were involved in the study selection, quality assessment, and data extraction. HB, and HM conducted the statistical analysis. ABY, SS, MG, HB, and HM wrote the first draft of the manuscript. All authors reviewed the manuscript, contributed to critical changes, and approved the final version of the manuscript for submission.

Corresponding author

Correspondence to Marjan Ghazisaeedi.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yazdipour, A.B., Saeedi, S., Bostan, H. et al. Opportunities and challenges of virtual reality-based interventions for patients with breast cancer: a systematic review. BMC Med Inform Decis Mak 23, 17 (2023). https://doi.org/10.1186/s12911-023-02108-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12911-023-02108-4

Keywords

  • Virtual reality
  • Breast cancer
  • Opportunities
  • Challenges
  • Systematic review

BMC Medical Informatics and Decision Making

ISSN: 1472-6947

Contact us