For hundreds of years, the written prescription has been the method of choice for physicians to communicate decisions on drug therapy, and for pharmacists to dispense medications, while at the same time being a source for the patient about how to use the medication in order to maximize its benefit. Currently, the medical prescription is at the transitional stage between paper and the electronic state. When adapting a traditional process to the new electronic era, unique opportunities and challenges are offered the involved actors: patients, prescribers, pharmacists, and also health care and EHR-system providers and other stakeholders [1].

New technologies may introduce new risks with the extended use of the prescription information in large-scale databases [2, 3]. A mistake by a prescriber may result in the incorrect medication being dispensed at the pharmacy, and also in the wrong documentation being recorded for future consultations. A mistake by a system programmer may also result in the incorrect medication being dispensed, but for a large group of patients. Future clinical decisions may also be based on wrong facts and assumptions, due to poor quality of the data provided. Thus, quality issues are even more accentuated in the electronic world [4].

The penetration rate of the Electronic Health Record (EHR) systems in Sweden is extensive, 86% of the employees in health care used EHR-systems in 2007 [5]. However, many different EHR-systems are employed, with varying ePrescription designs and functionalities. Even within a health care region or a single hospital, different EHR-systems are employed. Regardless of the EHR-system used, the prescriber must be confident with its functionality, effectiveness and safety.

The Swedish experience of ePrescribing began in 1983 with the world's first Electronically Transferred Prescription (ETP) for outpatients, between the computer systems in a doctor's office and a nearby outpatient pharmacy [6]. The first pilot project was followed by several others during the 1980's. After a new national strategy was decided at the end of the 1990's, the number of ePrescriptions in Sweden has escalated (Figure 1), with a penetration rate for ePrescriptions of about 70% of all new prescriptions in September 2008 [7]. More formal requirements (National ePrescription format, NEF) on the electronic communication process with automated quality checks are currently being implemented nationwide.

Figure 2 illustrates how ePrescriptions are transmitted, stored and dispensed in Sweden. An online prescription repository allows patients to store their prescriptions electronically for refills, and to have access to valid prescriptions (iterations included) at any pharmacy with the presentation of valid identification, making paper prescriptions obsolete. Patients may also have access to their stored prescriptions on the Internet by means of a secure digital authentication, enabling new services like mail-order delivery of prescription drugs.

The aim of the present study was to evaluate experienced ePrescribers' attitudes towards ePrescribing for suggesting improvements.

A majority of the respondents regarded their EHR-system easy to use in general (81%; 146/180) and for the prescribing of drugs (88%; 158/180) (Table 3). Most respondents believed they were able to provide the patients better service by ePrescribing (92%; 166/180), and regarded ePrescriptions to be time saving (91%; 164/180). Eighty-three percent (149/180) stated that ePrescriptions were safer than handwritten prescriptions. The different packages and the price were regarded clearly displayed by 78% (141/180) and 51% (91/180), respectively.

We found a difference in attitudes between physicians that were rare (< 5 ePrescriptions/day), intermediate (5–10 ePrescriptions/day) and extensive (> 10 ePrescriptions/day) users of ePrescribing. The intermediate and extensive users, to a greater extent than the rare users, regarded their EHR-system easy to use (p = 0.0003), easy to prescribe drugs with (p = 0.0001) and to be time saving (p ≤ 0.0001). The intermediate and extensive users, to a greater extent than the rare users, also regarded the patient's security number (p = 0.01) and name (p = 0.04), together with the price of the drug (p = 0.0002), to be clearly displayed. To the statements concerning safety and better service to the patients, extensive users agreed to a higher degree than intermediate and rare users (p = 0.01 and p = 0.0005, respectively). We found no differences in attitudes towards how the EHR-systems display different packages.

Respondents who had been using their EHR-system for ePrescribing more than one year, were more likely than respondents who had been using ePrescribing for less than a year, to regard their EHR-system easy to use (p = 0.004) and easy to prescribe drugs with (p = 0.004). They also, to a greater extent, regarded the patient's personal security number (p = 0.003) and name (p = 0.01) to be clearly displayed in their EHR-system when ePrescribing. However, there was no evidence that respondents who had been ePrescribing through their EHR-system for more than one year were more likely to regard ePrescriptions as time saving, safer or to perceive that they provided better service to patients. Also, we could not show any differences in attitudes concerning how the price and packages were displayed.

A minority of the respondents (13%; 23/180) perceived that it was possible to handle more than one patient at a time when ePrescribing. A majority (73%; 132/180) reported that they were always or often performing a final check of the ePrescription before transmitting; 25% (45/180) declared that they were seldom or never performing a final check.

The routines of cancelling prescriptions and of handling the situation when the ePrescription transfer is disrupted showed great variability (Figure 4 and 5). This variability could also be observed within the different EHR-systems. The answers to the question 'After sending an ePrescription to the pharmacy, do you get a receipt from the pharmacy that the ePrescription is received?' differed; 62% (111/180) reported they did not get a receipt, 26% (47/180) reported they got a receipt, and 12% (21/180) did not know.

The group of Swedish physicians studied was generally satisfied with their specific EHR-system and with ePrescribing as such. However, we identified some problems that may affect the ePrescribing process, e.g. one quarter of the physicians seldom or never performed a final check of the ePrescription before transmission, the drug choice was perceived to be complicated, and there were different routines among physicians when cancelling ePrescriptions or in case of disrupted ePrescription transmission. Also, more than half of the respondents reported a lack of receipt from the pharmacy after successful transmission of the ePrescription. These weaknesses in the ePrescribing process warrant improvements of the provided EHR-systems per se, as well as of their implementation in the individual health care organisation, and the associated training for users.

The present study was not designed to quantify differences or to rank the six different EHR-systems. Rather, it was useful to identify general attitudes among users, and also to reveal strengths and weaknesses in the ePrescribing processes. We regard our study to reflect the situation for the Swedish physicians in 2007 in the selected health care regions but not to be representative for all physicians, since the population included was selected and thus not a random sample. However, physicians from 7 out of 21 health care regions and 4 different disciplines were included. Furthermore, the six EHR-systems included in the study dominate the Swedish market. We cannot exclude that attitudes and behaviour differ from other health care regions depending on the EHR-system used, the organisation, and how the prescribers are trained and supported.

The results should be regarded as hypothesis generating, depending on the non-random method of recruitment. Our selections of regions and clinical heads as well as the clinical heads' ways to provide us with e-mail addresses represent potential risks for selection biases. A random sample of physicians and a higher response rate would have improved the validity of the study. In contrast to many other countries, Sweden has a single-payer health care system which might result in a less complex ePrescribing process. Consequently, the generalisability of the results to other nations might be limited.

We did not collect data about how long respondents had used handwritten prescriptions, and we cannot exclude that some respondents had never used handwritten prescriptions. However, given that the ePrescribing systems have been implemented at one clinic at a time, mainly during the last five years, and physicians work at a number of different clinics during their education and further training, we estimate the probability that a substantial proportion of the respondents had never used handwritten prescriptions as small.

A majority of the respondents stated that ePrescriptions are time saving, in agreement with previous studies [1, 11, 12]. A study using time-motion techniques to compare prescribing times for paper-based prescribing and ePrescribing reported no differences in prescribing times [13]. In our study, more than 90% of the physicians felt they were able to offer their patients better service by ePrescribing. An example of the improved service according to the respondents is that patients are able to fill the prescription at any Swedish pharmacy.

The varying answers to the questions about cancelling prescriptions and disrupted ePrescription transmission might be explained by the lack of distinct routines and training. When cancelling prescriptions, prescribers should always inform the pharmacy and cancel the prescription in the EHR. How to proceed when the ePrescribing transmission is disrupted depends on which EHR-system the prescriber is using. In some EHR-systems, the prescription is automatically sent when the transfer is restored, in others this function is missing. The prescriber needs to be aware of how disrupted ePrescribing transmission is managed in his/her specific EHR-system; otherwise the result could be duplicate prescriptions or no prescription at all. The finding that 13% of the physicians perceived it possible to handle more than one patient at a time was hard to interpret, as all EHR-vendors state that this is impossible.

For some of the survey items, rare users of ePrescriptions were found to have more negative attitudes and extensive users more positive attitudes towards ePrescribing. Physicians transmitting more than five ePrescriptions per day were more positive towards ePrescribing than those prescribing less with respect to ease of use, time savings, and how clearly the patient's personal security number and name together with the price of the drug were displayed. A similar pattern was seen when analysing differences between prescribers who had used their EHR-system for less than a year and prescribers who had used it for more than a year; the more inexperienced users being more negative about ease of use and how the personal security number and name were displayed. One explanation to the differences in attitudes between these groups might be that physicians have to use the ePrescribing function regularly and extensively in order to fully appreciate it [14, 15]. The ePrescribing function of the EHR-systems might not be intuitive enough for being fully appreciated also by rare users.

To improve the ePrescribing process, there is a need for extensive guidelines and distinct requirements from the authorities. There is also a need for good cooperation between EHR-system software providers and health care providers to enable compliance to these guidelines. We believe that it is necessary to have a more formal certification procedure of EHR-systems and ePrescribing.

Since ePrescription during the last few years has developed to be the regular way to prescribe drugs in Sweden, repeated user studies are warranted aiming at further improvement of quality and security of the ePrescription process. We also recommend research studies for investigation of new types of prescribing errors, including risk assessment for patients.

The Swedish physicians in the group studied were generally satisfied with their specific EHR-system and with ePrescribing as such. However, identified weaknesses warrant improvements of the EHR-systems as well as of their implementation in the individual health care organisation.