- Research article
- Open Access
Alerts for community pharmacist-provided medication therapy management: recommendations from a heuristic evaluation
BMC Medical Informatics and Decision Making volume 19, Article number: 135 (2019)
Medication therapy management (MTM) is a service, most commonly provided by pharmacists, intended to identify and resolve medication therapy problems (MTPs) to enhance patient care. MTM is typically documented by the community pharmacist in an MTM vendor’s web-based platform. These platforms often include integrated alerts to assist the pharmacist with assessing MTPs. In order to maximize the usability and usefulness of alerts to the end users (e.g., community pharmacists), MTM alert design should follow principles from human factors science. Therefore, the objectives of this study were to 1) evaluate the extent to which alerts for community pharmacist-delivered MTM align with established human factors principles, and 2) identify areas of opportunity and recommendations to improve MTM alert design.
Five categories of MTM alerts submitted by community pharmacists were evaluated: 1) indication, 2) effectiveness; 3) safety; 4) adherence; and 5) cost-containment. This heuristic evaluation was guided by the Instrument for Evaluating Human-Factors Principles in Medication-Related Decision Support Alerts (I-MeDeSA) which we adapted and contained 32 heuristics. For each MTM alert, four analysts’ individual ratings were summed and a mean score on the modified I-MeDeSA computed. For each heuristic, we also computed the percent of analyst ratings indicating alignment with the heuristic. We did this for all alerts evaluated to produce an “overall” summary of analysts’ ratings for a given heuristic, and we also computed this separately for each alert category. Our results focus on heuristics where ≤50% of analysts’ ratings indicated the alerts aligned with the heuristic.
I-MeDeSA scores across the five alert categories were similar. Heuristics pertaining to visibility and color were generally met. Opportunities for improvement across all MTM alert categories pertained to the principles of alert prioritization; text-based information; alarm philosophy; and corrective actions.
MTM alerts have several opportunities for improvement related to human factors principles, resulting in MTM alert design recommendations. Enhancements to MTM alert design may increase the effectiveness of MTM delivery by community pharmacists and result in improved patient outcomes.
There are many studies of electronic health record (EHR) medication alerts in hospital systems and physician office settings, but fewer studies have been conducted on medication-related alerts in community pharmacies with pharmacists as end users [1,2,3,4,5,6,7]. This area of research is needed given the complexity of medication use in ambulatory and community pharmacy settings. In the Medicare patient population, adverse drug events (ADEs) costs in the ambulatory setting from preventable medication therapy problems (MTPs) are estimated at $887 million annually . Medication therapy management (MTM) is a service, most commonly provided by pharmacists, intended to identify and resolve MTPs to enhance patient care . MTM consists of five key steps: 1) complete a targeted or comprehensive medication review (CMR) to identify MTPs, 2) provide a patient-specific personal medication list, 3) generate and provide a medication-related action plan, 4) intervention/referral, and 5) clinical documentation and follow-up .
To promote medication adherence and reduce ADEs among patients meeting specific criteria (e.g., chronically ill, using multiple medications), Medicare Part D plans must offer MTM, which includes an annual CMR. During the CMR, a pharmacist meets with a patient and/or caregiver to review all of the patient’s medications . Part D plans vary in their approach to meeting this requirement with some choosing to have pharmacists employed by the plan provide MTM telephonically while others contract with MTM vendors to provide MTM services through networks of community pharmacists . As of 2018, more than 60% of Part D plans utilize MTM vendor community pharmacy networks for at least some of their MTM-eligible patients .
MTM outcomes for patients, such as medication adherence and hospitalizations, have been inconsistent [13, 14]. Some of this variability may be attributed to alert design and functionality. MTM is typically documented by the community pharmacist in an MTM vendor’s web-based platform. These platforms often include integrated alerts to assist the pharmacist with assessing MTPs. For example, an MTM alert could prompt the pharmacist to speak with the patient during the CMR about possible medication non-adherence. Although alert design in the context of MTM has not been well-studied, possible limitations with alerts for MTM and considerations for alert design have been identified by our research group in prior qualitative work . For example, this research found that some MTM alerts (i.e., for assessing medication non-adherence) often falsely identified MTPs . Improving the design of MTM alerts could be a strategy to improve patient outcomes.
In order to maximize the usability and usefulness of alerts to the end users (e.g., community pharmacists), MTM alert design should follow principles from human factors science . The goal of human factors science is to “promote efficiency, safety, and effectiveness by improving the design of technologies, processes, and work systems” so that they support the physical and cognitive capabilities and limitations of humans . Extensive human factors research has been conducted on alert design in other domains including nuclear power , aviation , unmanned aerial systems , air traffic control , and hospital/physician office EHR-based medication safety ; our intent was to extend this work to MTM alert design.
The study objectives were to 1) evaluate the extent to which alerts for community pharmacist-delivered MTM align with established human factors principles and 2) identify areas of opportunity and recommendations to improve MTM alert design for use in community pharmacies.
This study was informed by the Systems Engineering Initiative for Patient Safety (SEIPS) v. 2.0 . As described in SEIPS 2.0, six work system components influence work processes, which thereby influence outcomes . One component is “tools and technology,” such as alerts for MTM. In addition, we used the MTP taxonomy described by Cipolle et al.  to organize our findings. According to this taxonomy, MTPs can be categorized as related to a medication’s: 1) indication (e.g., to assess whether a medication is medically indicated for the patient), 2) effectiveness (e.g., a higher dose of medication is recommended), 3) safety (e.g., a drug-drug interaction is present that increases the risk of toxicity for the patient), or 4) medication adherence (e.g., the patient has difficulty remembering to take their medication.)  For this study, we added a MTP category: 5) payer-driven alerts for cost-containment purposes (e.g., the alert recommends a brand to generic switch) to align with alerts that are available in MTM vendor platforms. Thus, as described below, we used these five categories to examine how the extent of alert alignment with human factors principles varies by category of MTP targeted by the MTM alert.
Setting, participants, and MTM alert systems
MTM vendors contract with pharmacies and payers on MTM program delivery. These vendors have developed web-based commercial documentation platforms in which pharmacists document MTM services. These platforms often include integrated alerts to assist the pharmacist in the assessment of MTPs. This study was conducted in collaboration with regional pharmacist/pharmacy practice-based research networks located in two different states: the Medication Safety Research Network of Indiana (Rx-SafeNet) and the Minnesota Pharmacy Practice-based Research Network (MPPBRN) [24, 25]. Community pharmacists from these networks were eligible to participate if they reported that they routinely provided CMRs for at least one of two national MTM vendors that require documentation in a web-based platform with integrated alerts. Eligibility criteria focused on these particular MTM vendors because the researchers were aware of their long-standing use by pharmacists in the collaborating networks. All MTM vendors with alerts evaluated as part of this study have been contracting on MTM program delivery for more than 10 years.
Study Design & Modification of I-MeDeSA
A heuristic evaluation is “one method for measuring usability … through which experts identify potential usability problems by comparing designs against established principles (i.e., heuristics).”  We followed established techniques to conduct a heuristic evaluation of MTM alerts [27,28,29,30]. A heuristic evaluation was chosen to understand how well MTM alerts align with established human factors principles and to maximize our ability to identify opportunities to enhance MTM alert design. The heuristic evaluation was guided by a modified version of the Instrument for Evaluating Human-Factors Principles in Medication-Related Decision Support Alerts (I-MeDeSA) . The original I-MeDeSA contains 26 heuristics pertaining to human factors principles and was designed to evaluate drug-drug interaction alerts associated with EHRs [21, 31, 32]. Because the original I-MeDeSA focused solely on drug-drug interactions, we modified it to encompass the broader alerts generated during MTM. Our modified version of the I-MeDeSA removed one heuristic and added 7 additional heuristics for a total of 32 heuristics pertaining to eight human factors principles: alarm philosophy, placement, visibility, prioritization, color, text-based information, proximity of task components being displayed, and corrective actions (Additional file 1). The additional heuristics incorporate usability design heuristics and human factors recommendations related to warning design . The scoring procedures for the I-MeDeSA were also modified to enable indication of heuristics that were “unable to be assessed” from screenshots, to avoid forcing analysts into an inaccurate response and provide insights on areas for future research. Prior to data analysis, the modified I-MeDeSA was piloted by two investigators (a research pharmacist and a human factors professional) with two rounds of review with example MTM alert screenshots.
Data collection: screenshots of MTM alerts
Following recruitment and training, community pharmacists submitted screenshots of MTM alerts that were generated by the MTM vendor platform as part of community pharmacists’ routine provision of CMRs. Pharmacists used HyperSnap software (Hyperionics, vs. 7 and 8, Boswell, PA)  to take screen shots associated with MTM alerts. Specifically, pharmacists were instructed to take screenshots representing their routine workflow for opening and responding to MTM alerts, including the initial screen from which the alert is accessed to the final screen where the alert is resolved or requires later action. They were instructed to redact any protected health information. Pharmacists were asked to submit alert screen shots for five MTP alert categories: 1) indication, 2) effectiveness; 3) safety; 4) adherence; and 5) payer-driven alerts for cost-containment purposes . Pharmacists submitted screenshots to our team using REDCap, a secure, web-based application developed to support the collection of research data . We asked pharmacists to start by submitting alerts for three patients, preferably with MTM alerts representing varying categories. Submitted MTM screenshots were first reviewed by two investigators (a research pharmacist and nurse.) The purpose of this review was to 1) ensure completeness of the submission (e.g., screenshots for each step in the pharmacist’s workflow) and request clarifying information from pharmacists when needed, and 2) to purposefully sample 1–2 alerts per category per vendor, with a goal of collecting a total of 24 alerts for our evaluation. As data collection proceeded, we provided guidance to pharmacists on categories of alerts that were still needed for data collection goals.
Data analysis: heuristic evaluation
Prior to analysis, a second pharmacist on the research team verified the categorization of MTM alerts made during the initial review. Four analysts conducted the heuristic evaluation. The analyst team was comprised of three human factors professionals and one pharmacist/MTM domain expert [27, 30]. This mix of analysts is supported by literature on heuristic evaluation, which demonstrates that at least 3 expert reviewers are needed, 3–5 reviewers can identify up to 75% of usability problems, and including domain experts (i.e., MTM, community pharmacy) can further strengthen the rigor and quality of results [27, 30]. Analysts completed a total of 3 h of training which included further pilot testing of the modified I-MeDeSA and minor revisions of the instrument to ensure clarity of heuristics for all analysts. This level of training aligns with recommendations from the literature .
Each analyst independently rated each alert on the modified I-MeDeSA. To maintain the same sentiment as scoring for the original I-MeDeSA (i.e., alerts scored a “1” for each heuristic met) but to enable investigators to distinguish between definite alignment and uncertainty, heuristics were scored as “0” when the alert “did not align” with the heuristic, “1” when the analyst was “unable to assess” whether the alert aligned with the heuristic (e.g., if the alert was appropriately timed but no specific timing information was available), and “2” when the “alert aligned” with the heuristic so that increasing scores reflected increased certainty in alert alignment. Therefore, for each evaluated MTM alert, the total possible scores on the modified I-MeDeSA ranged from 0 to 64 (32 heuristics each given a score of 2 would indicate alignment across all heuristics.) Analysts were required to enter explanatory comments when indicating “unable to assess” a heuristic or “not aligned” with the heuristic.
Some heuristics on the modified I-MeDeSA are applicable to individual alerts (alert-level) and others refer to the MTM vendor system as a whole (vendor system-level) (Additional file 1.) For vendor system-level heuristics on the modified I-MeDeSA, analysts scored each heuristic one time for each vendor by considering the body of all alerts evaluated for the vendor. Scores on vendor system-level heuristics were then used in computing scores for all alerts from that vendor.
Analysts completed all scoring in REDCap . For each MTM alert, analysts’ individual ratings were summed and a mean score on the modified I-MeDeSA computed. For each heuristic, we also computed the percent of analyst ratings indicating alignment with the heuristic. We did this for all alerts evaluated to produce an “overall” summary of analysts’ ratings for a given heuristic, and we also computed this separately for each alert category to determine whether specific heuristic alignment differed by alert category. All computations were performed using SPSS (IBM, v. 24, Armonk, NY) . Focus was made on heuristics where ≤50% of analysts’ ratings indicated alerts aligned with the heuristic. Analysts’ explanatory comments were also considered when summarizing findings and recommendations for future alert design for MTM. In an effort to provide comprehensive reporting of this evaluation, we consulted the STAR-HI statement in the preparation of this paper . This evaluation was approved by the Purdue University Institutional Review Board (IRB; study number 1608018057.) Pharmacists provided written informed consent; patient consent was waived by the IRB.
From April 2017 to March 2018, nine pharmacists, representing eight pharmacies, submitted data for a total of 77 MTM alerts and we selected a purposeful sample of 24 MTM alerts for inclusion in our heuristic evaluation (Table 1.) Screenshots are not provided here given the commercial, proprietary nature of MTM vendor systems.
Overall findings across MTM alert categories
Overall, alert categories were rated similarly to one another (Table 2.) Heuristics pertaining to visibility and color were generally met. The primary opportunities for improvement were found for heuristics related to five human factors principles (Table 3; prioritization; text-based information; alarm philosophy; proximity of task components being displayed; corrective actions) resulting in recommendations applicable to all, or most, MTM alert categories. One placement heuristic (Table 3) was noted as an improvement opportunity for many alert categories. Some heuristics related to placement and corrective actions could not be consistently assessed from MTM alert screenshots and, therefore, potential areas for improvement could not be fully elucidated.
Findings for specific alert categories
Adherence alerts were assessed the most favorably overall on the modified I-MeDeSA (Table 2) and adherence was the only alert category where five specific heuristics (Table 3; Additional file 1) were favorably assessed; these pertained to the following: color as a redundant cue for alert prioritization, proximity of information components on the alert, placement, where an alert is linked with the medication of concern by appropriate timing, minimizing text-based information, and corrective actions to prevent usability-related errors. No improvement opportunities unique to adherence alerts were identified.
Medication indication and safety
Analysts’ assessments of heuristics for alerts targeting medication 1) indication and 2) safety followed the same pattern as each other, and that of alerts overall, with two exceptions. First, for indication alerts, our finding suggests that the text-based information provided in existing designs may place unnecessary memory load on the end-user. Specifically, existing designs require pharmacists to memorize information from other parts of the MTM vendor platform to respond to the alerts. For example, when alerts advised the pharmacist to recommend the addition of a new medication, the pharmacist would need to navigate to another screen to review pertinent information such as other medications and diagnoses in order to decide whether the recommendation was appropriate. Second, also with regards to text-based information, safety alerts were rated more favorably than other alerts with regards to having a clear consequence statement. Indication and safety alerts also scored the most favorably on the heuristic pertaining to placement of information to facilitate quick uptake.
Medication effectiveness and cost
Analysts’ assessment of heuristics for alerts targeting 1) effectiveness and 2) cost MTPs followed the same pattern as each other, and that of alerts overall, with no improvement opportunities unique to either category.
This study extends prior research on alert design to identify leverage points for MTM alerts used by community pharmacists during medication reviews. Our research addresses a growing need by focusing on pharmacists as end users, the community pharmacy setting, and MTM alerts targeting complex, multimorbid patients--for which there is an overall paucity of literature on alerts [1, 7, 38]. Although extensive human factors studies of alert design have been conducted in other domains [17, 21], recent literature reviews have noted a critical need for further attention given to human factors principles in alert design in the healthcare domain [39, 40]. This research helps address this need and we anticipate that our findings can be used by MTM vendors that serve community pharmacies across the U.S., as well as for similar pharmacist-provided medication review services in other countries, such as those in the Netherlands and Australia [41, 42], to develop enhancements to MTM alerts to encourage alignment with human factors principles. To our knowledge, this study is also the first to apply the I-MeDeSA beyond the original work focused on drug-drug interaction alerts [21, 31, 32].
Recommendations across all MTM alert categories
We found that heuristics pertaining to visibility and the use of color were generally met by MTM alerts. We also identified opportunities for improvement that were consistent across all alert categories evaluated, as well as opportunities to strengthen specific alert categories. Our findings point to several recommendations for MTM alert design that could be considered by MTM vendors and others developing similar alerts for community pharmacists. Across all alert categories, four recommendations could be considered. First, vendors should ensure that a general catalog of MTPs, indicating associated MTM alerts priority level and severity of consequences is transparent to users to facilitate clear understanding of the MTM platform design and capabilities . This could be an electronic catalog, where these underlying components of the platform are conveyed to pharmacists via the alerts themselves, a help guide, via a dashboard, or another mechanism. Systematized nomenclature of medicine-clinical terms (SNOMED CT) could be used to guide this process . This improvement opportunity aligns with results of Marcilly et al.’s 2015 review of usability flaws of medication alerts which identified “function is not transparent enough to the user,” as a flaw, specifically noting a lack of transparency for “how alerts are categorized by severity.”  Second, clear alert definitions and consistent use of colors, shapes, icons, and signal words to indicate clinical priority may improve usability and better support decision making. Third, MTM alerts should display in order of clinical priority on the screen; for example, serious safety concerns could be displayed first. Fourth, to better support pharmacists in taking appropriate corrective actions, MTM alert design should facilitate direct communication between pharmacists and prescribers and integrate directly with pharmacy dispensing systems regarding pharmacist recommendations (e.g., to hold a prescription from being filled, pending prescriber approval of a dose change suggested during the CMR.) In summary, these four recommendations could be used to strengthen the design of MTM alerts, across all categories evaluated.
Recommendations for most MTM alert categories
Except for adherence alerts, which were stronger overall, we propose four additional recommendations for alerts based on our findings. First, signal words, such as “major drug-drug interaction,” are needed to denote clinical priority and should be used with other features such as colors, shapes, and icons as redundant visual cues. Color was the primary cue for many alerts in our study, but redundancies are needed to support users with color deficiencies. Similarly, a recent review of medication alerts as part of computerized prescriber order entry identified the need for better worded alerts utilizing explicit language . Second, alerts should be designed to enable the user to access relevant information (e.g., by clicking an “info button”) directly from the alert. This aligns with the findings of three recent literature reviews which highlight the potential benefits of embedded laboratory data as well as “info buttons” to provide relevant information to users as part of medication alerts [40, 45, 46]. Third, based on warnings literature  alert language should be concise, displaying short statements or bullet points rather than complete sentences. Consistent with our findings, the use of lengthy text was identified as a common problem during another recent heuristic evaluation of physician consultation order templates . Fourth, changes could be made to prevent potential usability-related errors. This includes changes to reduce extraneous clicks required from the pharmacist to improve efficiency. For instance, design changes could be made to reduce the potential for “pick list” errors  by removing some of the drop-down menus and replacing them with radio buttons or checklists.
Recommendations for specific MTM alert categories
In addition, all alerts should include a consequence statement that clearly informs the user as to what might happen if the alert were ignored. This was identified as an improvement opportunity for most alert categories, with safety alerts being the exception because they consistently included a consequence statement already. For example, a consequence statement for an indication-related MTM alert of “needs additional drug therapy” could read, “Lack of statin therapy for a patient with a high risk for cardiovascular disease will increase their likelihood for a heart attack or stroke.” Moreover, with the exception of indication and safety alerts, alert design could be improved to facilitate quick uptake of information by the end user by moving critical information to the top and left position in the alert screen to align with the reading process. Spacing should also be used to separate the most critical information from other details, critical information should be grouped, and bullet points should be used in place of prose . Finally, for indication alerts, changes are recommended to minimize the memory load of the end user by providing key patient-specific information on the alert that is needed for decision-making; examples include a summary of medications the patient tried in the past along with relevant laboratory data.
Comparison with findings for EHR alerts
For some heuristics, our findings align with Phansalkar et al.’s results for EHR drug-drug interaction alerts . For example, visibility heuristics were rated favorably in both their evaluation and ours as well. Interestingly, this contrasts with the findings of a heuristic evaluation of an electronic medication administration record where violations of visibility heuristics were common . In addition, both ours and Phansalkar’s evaluations found improvement opportunities for alarm philosophy and prioritization heuristics . In contrast, whereas proximity of task components was assessed favorably for EHR drug-drug interaction alerts , we found improvement opportunities for this heuristic for most categories of MTM alerts. Moreover, while the placement of information was assessed favorably for EHR alerts , we found improvement opportunities for some alert categories with regards to the alert layout needing to better facilitate quick uptake of information.
There are limitations to our evaluation. First, for most alert categories, we were unable to consistently assess whether alerts were linked with the medication by appropriate timing. This is due to the static nature of the screenshots used in our evaluation; in contrast, the reviewers who evaluated the EHR alerts for Phansalkar et al. requested a walk-through (via web-conference) of the EHR vendor systems when a screenshot was insufficient for evaluating a heuristic . Second, in spite of our efforts to identify alert examples for each category from both MTM vendors, cost alerts were obtained from only one MTM platform. Moreover, it is important to note that different types of specific MTPs are represented within each category. While we made an effort to sample alerts targeting a range of specific MTPs for each category (Table 1), we did not require the same number of each MTP per category nor did we capture the same specific alerts from each vendor. Our study is unlikely to capture all variation of alert design within a given alert category. Therefore, our recommendations might vary in applicability to specific alerts within each category/vendor. Future research could focus on a specific alert category and further assess effective strategies to improve the design of alerts for specific MTM alert categories. Third, while pharmacist investigators applied a specific well-accepted taxonomy for MTPs to categorize alerts , different pharmacists or the application of a different taxonomy for MTPs might have resulted in different categorization. Fourth, we believe that at least one of the MTM vendors made some changes to alerts during our data collection period, which could have influenced our findings. Fifth, while some commonalities across the EHR drug-drug interaction alert evaluation  and our current MTM alert evaluation were noted, direct comparisons of I-MeDeSA scores from the two evaluations are not possible since we modified the I-MeDeSA language, added heuristics, and modified the scoring approach. Moreover, it is important to note that an overall numeric score on the modified I-MeDeSA alone does not provide insight into the severity of heuristic violations and any changes in I-MeDeSA scores following changes in alert design could reflect a particular heuristic being met while violating other heuristics. In any heuristic evaluation, quantitative scores should serve as a guide to note potential violations and should be interpreted in the context of qualitative data. Finally, our evaluation only assessed MTM alerts for alignment with heuristics included in the modified I-MeDeSA. Other recommendations for medication alert design exist, including those described by Pelayo et al. 
Opportunities for future research
Our findings point to several opportunities for further research. For example, there is a need for formal usability testing with community pharmacists to identify potential usability errors that might not be detected by a heuristic evaluation of screenshots. Moreover, heuristic evaluation relies on experts’ analyses, but as emphasized in recent literature reviews, user-centered design principles are paramount in alert design [39, 40]. Therefore, data collected directly from end users (i.e., pharmacists) should also be considered in MTM alert re-design and future research should examine the perspectives of pharmacists and other end users involved in resolving MTM alerts. Studies are also needed to evaluate any alert enhancements made in response to recommendations informed by this evaluation. A prior simulation study where usability testing was conducted with EHR alerts and prescribers demonstrated that redesigning EHR alerts to better align with human factors principles increased prescribers’ efficiency and reduced prescribing errors, however it is unknown whether MTM alert changes would result in similar positive outcomes .
This is one of the first studies to evaluate MTM alerts and the first, to our knowledge, to evaluate MTM alerts used by community pharmacists for alignment with human factors principles. We found that MTM alerts generally have opportunities for improvement related to several human factors principles, especially as related to alert prioritization, text-based information, alarm philosophy, and corrective actions. We expect that our findings and recommendations can be used by MTM vendors and community pharmacies across the U.S. to develop enhancements to MTM alerts. The subsequent changes made to MTM alerts are expected to enhance usability for pharmacists and improve patient outcomes. MTM alert recommendations have not yet been implemented and tested, however, and should be evaluated in future research.
Availability of data and materials
Data sharing is not appropriate for this article as this heuristic evaluation reports on a very small sample size of alert screenshots.
Adverse drug events
Comprehensive medication review
Electronic health record
Instrument for Evaluating Human-Factors Principles in Medication-Related Decision Support Alerts
Institutional Review Board
Minnesota Pharmacy Practice-based Research Network
Medication therapy management
Medication therapy problem
Medication Safety Research Network of Indiana
Systems Engineering Initiative for Patient Safety
Systematized nomenclature of medicine-clinical terms
Statement on reporting of evaluation studies in health informatics
McKibbon KA, Lokker C, Handler SM, Dolovich LR, Holbrook AM, O’Reilly D, Tamblyn R, Hemens BJ, Basu R, Troyan S, Roshanov PS, Archer NP, Raina P. Enabling Medication Management Through Health Information Technology. Rockville: Agency for Healthcare Research and Quality (AHRQ) AHRQ Publication No. 11-E008-EF; 2011.
Bright TJ, Wong A, Dhurjati R, et al. Effect of clinician decision-support systems. A systematic review. Ann Intern Med. 2012;157:29–43.
Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety. Arch Intern Med. 2003;163:1409–16.
Curtain C, Peterson GM. Review of computerized clinical decision support in community pharmacy. J Clin Pharm Ther. 2014;39:343–8.
Watkins K, Wood H, Schneider CR, Clifford R. Effectiveness of implementation strategies for clinical guidelines to community pharmacy: a systematic review. Implement Sci. 2015;10:151.
Miller L, Pater KS, Corman S. The role of clinical decision support in pharmacist response to drug-interaction alerts. Res Soc Adm Pharm. 2015;11:480–6.
Saverno KR, Hines LE, Warholak TL, et al. Ability of clinical decision-support software to alert users about clinically important drug-drug interactions. J Am Med Inform Assoc. 2011;18:32–7.
Field TS, Gilman BH, Subramanian S, Fuller JC, Bates DW, Gurwitz JH. The costs associated with adverse drug events among older adults in the ambulatory setting. Med Care. 2005;43(12):1171–6.
Bluml BM. Definition of medication therapy management: development of professionwide consensus. J Am Pharm Assoc. 2005;45:566–72.
American Pharmacists Association; National Association of Chain Drug Stores Foundation. Medication therapy management in pharmacy practice: core elements of an MTM service model (version 2.0). J Am Pharm Assoc. 2008;48:341–53.
Centers for Medicare and Medicaid Services (CMS) HHS. Medicare program; medicare prescription drug benefit, Final Rule. Federal Register. 2005;70:4193–585.
Centers for Medicare and Medicaid Services. 2018 Medicare Part D medication therapy management (MTM) programs. Fact Sheet. Summary of 2018 MTM Programs. Available at: https://www.cms.gov/Medicare/Prescription-Drug-Coverage/PrescriptionDrugCovContra/Downloads/CY2018-MTM-Fact-Sheet.pdf. Accessed 14 Jan 19.
Agency for Healthcare Research and Quality. Effective Health Care Program Medication Therapy Management Interventions in Outpatient Settings Executive Summary. 2014. https://effectivehealthcare.ahrq.gov/sites/default/files/related_files/medication-therapy-management_executive.pdf
Viswanathan M, Lahwati LC, Golin CE, et al. Medication therapy management interventions in outpatient settings: a systematic review and meta-analysis. JAMA Intern Med. 2015;175:76–87.
Snyder ME, Jaynes HA, Gernant SA, Lantaff WM, Hudmon KS, Doucette WR. Variation in medication therapy management (MTM) delivery: implications for healthcare policy. J Manag Care Spec Pharm. 2018;24:896–902.
Russ AL, Fairbanks RJ, Karsh B, Militello LG, Saleem JJ, Wears RL. The science of human factors: separating facts from fiction. BMJ Qual Saf. 2013;22:802–8.
Sheridan TB. Understanding human error and aiding human diagnostic behaviour in nuclear power plants. In: Human detection and diagnosis of system failures. Boston: Springer; 1981. p. 19–35.
Wickens C, Colcombe A. Dual-task performance consequences of imperfect alerting associated with a cockpit display of traffic information. Hum Factors. 2007;49(5):839–50.
McCarley JS, Wickens CD. Human factors implications of UAVs in the national airspace; 2005.
Wickens CD, et al. False alerts in air traffic control conflict alerting system: is there a “cry wolf” effect? Hum Factors. 2009;51(4):446–62.
Phansalkar S, Edworthy J, Hellier E, Seger DL, Schedlbauer A, Avery AJ, Bates DW. A review of human factors principles for the design and implementation of medication safety alerts in clinical information systems. JAMIA. 2010;17:493–501.
Holden RJ, Carayon P, Gurses AP, et al. SEIPS 2.0: a human factors framework for studying and improving the work of healthcare professionals and patients. Ergonomics. 2013;56:1669–86.
Cipolle RJ, Strand LM, Morley PC. Pharmaceutical Care Practice. McGraw Hill: The Clinician’s Guide; 2004.
Purdue University College of Pharmacy. Medication Safety Research Network of Indiana (Rx-SafeNet). Available at: https://www.pharmacy.purdue.edu/rx-safenet. Accessed 11 Jan 19.
Minnesota Pharmacy Practice-Based Research Network. Available at: http://www.mpha.org/associations/9746/files/PBRN/index.html. Accessed 14 Jan 19.
Savoy A, Patel H, Flanagan ME, Weiner M, Russ AL. Systematic heuristic evaluation of computerized consultation order templates: clinicians’ and human factors engineers’ perspectives. J Med Syst. 2017;41:129.
Jaspers MWM. A comparison of usability methods for testing interactive health technologies: methodological aspects and empirical evidence. Int J Med Inform. 2009;78:340–53.
Thyvalikakath TP, Schleyer TKL, Monaco V. Heuristic evaluation of clinical functions in four practice management systems. J Am Dent Assoc. 2007;138:209–18.
Nielsen J, Molich R. Heuristic evaluation of user interfaces. Assoc Comput Mach. 1990:249–56.
Zhang J, Johnson TR, Patel VL, Paige DL, Kubose T. Using usability heuristics to evaluate patient safety of medical devices. J Biomed Inform. 2003;36:23–30.
Zachariah M, Phansalkar S, Seidling HM, Neri PM, Cresswell KM, Duke J, Bloomrosen M, Volk LA, Bates DW. Development and preliminary evidence for the validity of an instrument assessing implementation of human-factors principles in medication-related decision-support systems - I-MeDeSA. J Am Med Inform Assoc. 2011;18:62–72.
Phansalkar S, Zachariah M, Seilding HM, Mendes C, Volk L, Bates DW. Evaluation of medication alerts in electronic health records for compliance with human factors principles. J Am Med Inform Assoc. 2014;21:e332–e340. https://doi.org/10.1136/amiajnl-2013-002279.
Wogalter MS. Handbook of warnings. Mahwah: Lawrence Erlbaum Associates; 2006.
HyperSnap™. Available at: http://www.hypersnap.com/home.asp. Accessed 15 Feb 2016.
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap) – a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009 Apr;42(2):377–81.
IBM SPSS software. Available at: https://www.ibm.com/analytics/us/en/technology/spss/. Accessed 11 Jan 19.
Brender J, Talmon J, de Keizer N, et al. STARE-HI-statement on reporting of evaluation studies in health informatics: explanation and elaboration. Appl Clin Inf. 2013;4:331–58.
Bilici E, Despotou G, Arvanitis TN. The use of computer-interpretable clinical guidelines to manage care complexities of patients with multimorbid conditions: a review. Digital Health. 2018;4:1–21.
Tolley CL, Slight SP, Husband AK, Watson N, Bates DW. Improving medication-related clinical decision support. Am J Health-Syst Pharm. 2018;75:239–46.
Brown CL, Mulcaster HL, Triffitt KL. A systematic review of the types and causes of prescribing errors generated from using computerized provider order entry systems in primary and secondary care. J Am Med Inform Assoc. 2017;24:432–40.
Chau S, Jansen APD, van de Ven PM, et al. Clinical medication reviews in elderly patients with polypharmacy: a cross-sectional study on drug-related problems in the Netherlands. Int J Clin Pharm. 2016;38(1):46–53.
6th Community Pharmacy Agreement. Home Medicines Review. Available at: http://6cpa.com.au/medication-management-programs/home-medicines-review/. Accessed 14 Jan 19.
Russ AL, Saleem JJ, McManus MS, Zillich AJ, Doebbeling BN. “Computerized Medication Alerts and Prescriber Mental Models: Observing Routine Patient Care”, Proceedings of the Human Factors and Ergonomics Society, 53rd Annual Meeting, San Antonio, TX, [CD-ROM] 655–659, Oct 2009.
Academy for Managed Care Pharmacy, Pharmacy Quality Alliance, and the Pharmacy Health Information Technology Collaborative. Standardized Framework for Cross-Walking Therapy Management Services to SNOMED CT Codes). Available at: https://www.prnewswire.com/news-releases/pharmacy-stakeholders-release-standardized-documentation-of-medication-therapy-management-mtm-services-using-snomed-ct-codes-300354025.html.
Marcilly R, Ammenwerth E, Vasseur F, Roehrer E, Beuscart-Zéphir MC. Usability flaws of medication-related alerting functions: a systematic qualitative review. J Biomed Inform. 2015:260–71.
Van de Velde S, Heselmans A, Delvaux N, et al. A systematic review of trials evaluating success factors of interventions with computerised clinical decision support. Implement Sci. 2018;13:114.
RTI International. Report on the safe use of pick lists in ambulatory care settings. Prepared for the Office of the National Coordinator for Health Information Technology under contract number HHSP23320095651WC_HHSP233337047T. September 2016.
Guo J, Iribarren S, Kapsandoy S, Perri S, Staggers N. Usability evaluation of an electronic medication administration record (eMAR) application. Appl Cin Inf. 2011;2:202–24.
Pelayo S, Marcilly R, Bernonville S, Leroy N, Beuscart-Zephir MC. Human factors based recommendations for the design of medication related clinical decision support systems (CDSS). User Centred Networked Health Care. 2011:412–6.
Russ AL, Zillich AJ, Melton BL, et al. Applying human factors principles to alert design increases efficiency and reduces prescribing errors in a scenario-based simulation. J Am Med Inform Assoc. 2014;21(e2):e287–96.
We wish to thank the pharmacists from the Medication Safety Research Network of Indiana (Rx-SafeNet) and the Minnesota Pharmacy Practice-based Research Network (MPPBRN) for their participation and assistance with data collection for this study. Thank you also to Wendy Lantaff, PharmD, MS for her contributions to study design during the grant submission process.
A portion of this work was presented as part of a national AHRQ webinar on “The Role of Health IT to Improve Medication Management” in September 2018 and as a podium presentation at the 2018 American Medical Informatics Association Annual Symposium in San Francisco, CA.
This project was supported by grant number R21HS025005 from the Agency for Healthcare Research and Quality (PI: Snyder). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality. The funding agency had no role in the design of the study, the collection, analysis, and interpretation of data, and in writing the manuscript. Dr. Adeoye is supported by the Indiana Clinical and Translational Sciences Institute funded, in part by Award Number TL1TR001107 (A. Shekhar, PI) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Ethics approval and consent to participate
This evaluation was approved by the Purdue University Institutional Review Board (IRB; study number 1608018057.) Pharmacists provided written informed consent; patient consent was waived by the IRB.
Consent for publication
Dr. Snyder reports that she serves as a consultant to Westat, Inc. on an evaluation of the Centers for Medicare and Medicaid Services’ Enhanced MTM program. Ms. Militello reports that she is co-owner of Applied Decision Science, LLC. All other authors report that they have no conflicts of interest.
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Additional file 1:
Modified I-MeDeSA. Contains a copy of the modified I-MeDeSA used to guide this heuristic evaluation. (DOCX 23 kb)
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Snyder, M.E., Jaynes, H., Gernant, S.A. et al. Alerts for community pharmacist-provided medication therapy management: recommendations from a heuristic evaluation. BMC Med Inform Decis Mak 19, 135 (2019). https://doi.org/10.1186/s12911-019-0866-0
- Decision support systems, clinical
- Community pharmacy services
- Medication therapy management