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A decision support system to determine optimal ventilator settings
© Patlar Akbulut et al.; licensee BioMed Central Ltd. 2014
Received: 28 October 2012
Accepted: 1 July 2013
Published: 10 January 2014
Choosing the correct ventilator settings for the treatment of patients with respiratory tract disease is quite an important issue. Since the task of specifying the parameters of ventilation equipment is entirely carried out by a physician, physician’s knowledge and experience in the selection of these settings has a direct effect on the accuracy of his/her decisions. Nowadays, decision support systems have been used for these kinds of operations to eliminate errors. Our goal is to minimize errors in ventilation therapy and prevent deaths caused by incorrect configuration of ventilation devices. The proposed system is designed to assist less experienced physicians working in the facilities without having lung mechanics like cottage hospitals.
This article describes a decision support system proposing the ventilator settings required to be applied in the treatment according to the patients’ physiological information. The proposed model has been designed to minimize the possibility of making a mistake and to encourage more efficient use of time in support of the decision making process while the physicians make critical decisions about the patient. Artificial Neural Network (ANN) is implemented in order to calculate frequency, tidal volume, F i O 2 outputs, and this classification model has been used for estimation of pressure support / volume support outputs. For the obtainment of the highest performance in both models, different configurations have been tried. Various tests have been realized for training methods, and a number of hidden layers mostly affect factors regarding the performance of ANNs.
The physiological information of 158 respiratory patients over the age of 60 and were treated in three different hospitals between the years 2010 and 2012 has been used in the training and testing of the system. The diagnosed disease, core body temperature, pulse, arterial systolic pressure, diastolic blood pressure, PEEP, P S O 2, pH, p C O 2, bicarbonate data as well as the frequency, tidal volume, F i O 2, and pressure support / volume support values suitable for use in the ventilator device have been recommended to the physicians with an accuracy of 98,44%. Performed experiments show that sequential order weight/bias training was found to be the most ideal ANN learning algorithm for regression model and Bayesian regulation backpropagation was found to be the most ideal ANN learning algorithm for classification models.
This article aims at making independent of the choice of parameters from physicians in the ventilator treatment of respiratory tract patients with proposed decision support system. The rate of accuracy in prediction of systems increases with the use of data of more patients in training. Therefore, non-physician operators can use systems in determination of ventilator settings in case of emergencies.
The use of decision support systems  in health provides improvement in terms of the quality of health and care, early diagnosis of diseases, prevention of person related errors, lowering costs and providing the patients with the optimum treatment.
Today, most physicians prefer the decision support systems in the interest of the effective operation and early determination of the most appropriate option in order to avoid the growing problem related to the management of medical information. The decision support systems are the most ideal aids in either detection or treatment of a disease, or determination of the most appropriate drug.
A basic requirement of our survival is to take a sufficient amount of air and to transfer it to all our cells. While heart and blood cells are responsible for distribution, our lungs perform the exchange of oxygen (O 2) and carbon dioxide (C O 2) by holding a medietary position between the atmosphere and the internal organs. The delivery of oxygen and removal of carbon dioxide, which are the two most important components of the inspiration - expiration process is, called “breathing” . The respiratory function is autonomously carried out in healthy living beings and is artificially carried out in those with lung disease and respiratory failure. The device that is used in this process is called as the ventilator device  and the process is called ventilation.
The physiological parameters determined in accordance with the findings of the patient who is connected to the ventilator device change simultaneously depending on the instantaneous status of the patient after the device has been inserted. The most critical point here is to determine the device parameters in the desired accuracy. Since the task of specifying the parameters of ventilation equipment is carried out entirely by a physician, the physician’s knowledge and experience in the selection of these settings have a direct effect on the accuracy of his/her decisions. The process of determination of the device parameters with a decision support system to be developed for this decision process can be completed with minimum error by predicating the instantaneous status of the patient. By this way, the decision making processes of physicians can be implemented in a faster and a more accurate manner.
This study describes a decision support system designed to automatically determine the ventilator settings in consideration of the ventilation data obtained from two different hospitals. For the model system in our study, COPD (Chronic Obstructive Pulmonary Disease) and CVD (Cerebrovascular Disease) have been used as respiratory diseases. COPD  is a disease that causes the obstruction of the bronchi on the long term and that has no treatment. ARDS  is the acute respiratory distress syndrome caused by the increase in the alveolar capillary permeability. CVD  is a group of disorders with symptoms related to the damaged brain region associated with the blockage or bleeding of the arteries supplying the brain. Although CVD is not a respiratory disease, almost all CVD patients are treated with ventilation devices.
According to the Turkish Statistical Institute’s report of causes of death statistics , 16.311 patients died of disease caused by COPD (J40-J44) and 30.103 patients died of disease caused by CVD (I60-I69) in 2009. In total mortality of 2009, it corresponds to 16,5%.
For this reason, the management of mechanical ventilation devices used in intensive care units is a critical process. Our goal is to minimize errors in this process and prevent deaths caused by incorrect configuration of ventilation devices. This system is designed for the facilities without having lung mechanics like cottage hospitals in country regions. Metropolitan cities have fully equipped hospitals with experienced medical personnel, but on the other hand less experienced doctors can benefit from this system. Our proposed method is facilitated upon making the medical data of patients meaningful with help of an Artificial Neural Network (ANN) , and the determination of the preferred treatment factors.
Below, further studies conducted so far with regards to the subject of our study have been summarized.
In the study of Adeney, Ennett, Frize and Korenberg , this methodology is used and a model using two-stage ANN is presented. It is observed from the test results that a high success rate is provided with regards to the estimation of the parameters.
A similar study has simultaneously performed the inspiration – expiration of the intensive care patients by a ventilator device . The model working in accordance with the data such as the patient’s breathing frequency, the density of oxygen in their blood and the flow wavelength of the blood has estimated the ideal working time.
Borrello’s study  is a detailed modeling of a prototype which is thought as a replacement for the standard ventilator devices and which provides assistance for the operator with regards to the parameters to be selected through its own processor and sensor.
In the study of Tehrani , a closed-loop decision support system that foresees the leaving time of the patient from the ventilator depending on values P C O 2 (Partial Pressure of Carbon Dioxide), P S O 2 (Partial Pressure of Sulfur Dioxide), F i O 2 (Fraction of Inspired Oxygen), PEEP (Positive End-Expiratory Pressure) parameters was proposed.
In another study , simulations have been implemented in the MATLAB environment by using the hybrid algorithm for the ventilators used in intensive care units. With the designed model, the settings regarding the parameters of the blood gasses like F i O 2, PEEP, Pinsp, Vrate are recommended to the physician by the system.
Another computer aided ventilator prototype study  was developed by Ahmedi and Bates. Prototype ventilator opens and closes the valve by the help of the computer program, which sustains the process of inspiration and expiration.
Zhu  and Allerød  proposed ventilation settings with a decision support system according to the patient’s physiological characteristics of the patient to be undergone ventilation, by using ANNs. While Zhu has used the data from 28 ARDS patients in his study; Allerød used the data from 20 CABG patients. In both studies, it is shown that patient characteristics are important in the selection of the ventilator settings.
As a result, it is seen in the research articles  related to the methodology of the ventilator devices controlled by the smart control techniques that the influence of the decision support systems on the decisions of the physician have been quite successful.
Er, Yumusak and Temurtas  presented a comparative chest diagnosis; for chronic obstructive pulmonary, pneumonia, asthma, tuberculosis and lung cancer diseases which was realized by using multilayer, probabilistic, learning vector optimization, and generalized regression.
Gil et al.  used ANN models as tools for support in the medical diagnosis of urological dysfunctions. They developed two types of unsupervised and one supervised neural network to distinguish and classify between ill and healthy patients.
Ushida et al.  used fuzzy neural network analysis (FNN) of health check-up data to provide a personalized novel diagnostic and therapeutic method involving the y-GTP level and the WBC count. They performed a logistic regression analysis, including adjustment to ensure FNN analysis was statistically reliable.
Heckerling et al.  used ANN coupled with genetic algorithms to evolve combinations of clinical variables optimized for predicting urinary tract infection for women. Their method revealed that parsimonious variable sets accurate for predicting urinary tract infection, and novel relationships between symptoms, urinalysis findings, and infection.
The Faculty of Medicine, the Electronic and Computing Engineering Department of the Federal University of Rio de Janeiro (UFRJ) and the Electrical Engineering Department of the Federal Center of Technological Education (CEFET-RJ) worked on a collaborative research project to develop a decision support system for smear negative pulmonary tuberculosis (SNPT) . This project aims to develop, through a multi-disciplinary, multi-institutional, innovative and cost-effective approach, new paradigms to prevent the disease progression and support the rapid evaluation of new therapies.
Moein, Monadjemia and Moallem , investigated typical disease diagnoses using ANNs. After selecting some symptoms of eight different diseases, MLP neural network was used with a fuzzy approach to get more accurate results.
Kamruzzaman and Islam , proposed an algorithm, called rule extraction from ANNs (REANN), to extract rules from trained ANNs for medical diagnosis conditions like breast cancer, diabetes and lenses problem.
Lisboa and Taktak  conducted to assess the benefit of ANNs as decision making tools in the field of cancer. Their study describes the work being done in this area over the last decade.
Clinical applications of ANNs provide benefits in many areas, and there are still many more perspectives to be examined like ethics and clinical prospects .
In the Methods Section, the methodology and design elements of the decision support system are detailed. Experimental results and conclusion are given in Section “Results and discussion” and Section “Conclusions”, respectively.
Data collection and analysis
A medium-sized data set has been used in order to test the accuracy of the model. Data set includes information of 158 respiratory patients who were over the age of 60 and were collected from 3 different hospitals between the years 2010 and 2012.These hospitals are Kartal Kosuyolu Training and Research Heart Hospital, Taksim Training and Research Hospital and Marmara University Pendik Training and Research Hospital. We are allowed to collect patients’ data for this research from Health Directorate of Istanbul and hospital administrations respectively. All data is taken from patient registration forms of intensive care units from hospital archives. While collecting data set, 1 day data of each patient was considered and the overall value was calculated and recorded as the data of the concerned person. Because deviations of the measurements made during the day were not remarkable, we decided to work with the daily averaged values. Data is used as untouched, no statistical analysis or normalization was applied to collected data.
There are 15 different physiological parameters for each patient in the data set. Each parameter has been considered as a different feature. Parameters of the data set were determined as follows: core body temperature, pulse, arterial systolic pressure, diastolic blood pressure, PEEP, p S O 2, pH, p O 2, p C O 2, bicarbonate, frequency as inputs, F i O 2, tidal volume, pressure support and volume support as outputs. Because of being the intensive care units of the hospitals are too busy, doctors only record the important parameters of ventilation devices of their patients. Therefore, it is not possible to find the same parameters on the patient registration forms. This is why we have chosen the values of frequency, tidal volume, F i O 2 and ventilation modes as output parameters. There are three types of ventilation modes used in the system; SIMV (Synchronized Intermittent Mandatory Ventilation) as pressure support mode and CPAP’s (Continuous Positive Airway Pressure) both volume support and pressure support modes.
If we look at the detailing of the proposed system, the first stage is the part that confirms the physiological values of the patients. At this level, all findings are evaluated by the system, and are checked prior to entering to ANN. The diagnosis regarding the disease of the patient is controlled by the available data in the system. Bayesian model used in the determination of the disease is described in disease detection by Bayesian forecast model section. The system, after checking the entries, evaluates the data that is inappropriate for to the model as a possible faulty entry and alerts the physician. After the physician confirms the data, second stage is put into operation. We do not prefer to feed data directly to ANN, because sub setting the whole data with Bayesian model gives more accurate results in ANN experiments. Only determined disease oriented data is used in ANN. In this point of view, first stage of the system acts like the supervisor of the second stage.
In the second stage of the system, the data related to the patient is formed and entered to ANN. By using the fore mentioned data, ANN produces the tidal volume, frequency and F i O 2 ventilator settings to be used in treatment of patient. The treatment starts when the physician installs the proposed settings to the ventilator. Operation details of ANN are presented in Calculation of the ventilator settings with Artificial Neural Network.
Disease detection by Bayesian forecast model
Bayesian  approach commonly used in the decision support systems is based on an objective point of view in a probabilistic examination of knowledge. The approach focuses on the multiple stages of the information, rather than its accuracy, and allows for the calculation of the future probabilities.
Distribution is directly related to the number of persons corresponding to the physiological parameters. Total number of patients is the normalizing factor which is used to guarantee the sum of all probabilities is equals to 1.
Probabilities of occurrence of COPD, ARDS and CVD diseases
Physiological parameter (x)
COPD (F COPD )
ARDS (F ARDS )
CVD (F CVD )
Core body temperature
Arterial systolic pressure
Diastolic blood pressure
Calculation of the ventilator settings with Artificial Neural Network
The second stage of the decision support system begins with the acceptance of the accuracy of the forms of entries. ANN used in the second stage of the system, is implemented via the MATLAB. Because of having the ability to learn complex nonlinear input-output relationships, use sequential training procedures, and adapt themselves to the data, we prefer to work with ANNs.
ANN operates in two different modes. In order to calculate the frequency, tidal volume and F i O 2 outputs, regression model has been used and the classification model has been used for the estimation of the pressure support/volume support outputs. For obtaining the highest performance in both models, different configurations have been tried. Various tests have been realized for the training method and the number of hidden layers , which are the factors affecting the performance of ANNs the most.
While working on the training method, 4 backpropagation and 2 supervised training algorithms have been used. The used backpropagation training algorithms are as follows: Levenberg-Marquardt, Bayesian Regulation, One step secant and BFGS quasi-Newton. For the other 2 supervised training algorithms, Cyclical order weight/bias and Sequential order weight/bias were preferred.
In order to find the number of hidden layers with which all the entire training algorithms give the best performance, layer numbers of 5, 10, 15, 20,30, 50 and 100 have been tried. Results for all tests are detailed in Section “Results and discussion”.
Results and discussion
Prior to the second step of the system which is the estimation of the ventilator settings, the probabilities of the diseases were predicted and presented to the physician, and upon the verification of relevant disease or determination of a new disease by the physician, they were sent as parameters for the predicted model of ventilator settings.
Results for ANNs Using 10-fold cross validation
Learning Alg./Output parameters
One step secant
Cyclical order weight/bias training
Sequential order weight/bias training
The most successful configurations and success rates provided by the training algorithms used in the regression and classification models
Hidden layer count
Process time (s)
Hidden layer count
Process time (s)
Pressure support/ Volume support
One step secantbackpropagation
Cyclical order weight/biastraining
Sequential order weight/bias training
As seen from the examples provided in Table 3, when the results produced by the decision support system we proposed are compared to the ventilator settings actually used for obtaining data; it is shown that the success rates in the prediction of frequency parameter, tidal volume parameters, F i O 2 parameters and pressure support/volume support parameter are 99,81%, 99,54%, 100% and 94,40%, respectively.
Furthermore, proposed models field tests conducted on 14 patients of 2 different doctors show that, the system trained with 158 patient data recommended the ventilator settings with 95,3% accuracy. This percentage has remained low compared to the simulation results, but this ratio provides a satisfactory grade for the use of our proposed system in real life. It is clear that, gaining more data to train the system increase this success ratio.
This article has aimed at making the parameter selection process in the ventilator treatment period of the respiratory tract patients independent from the physician, via the decision support system proposed. As seen from the experimental test results, the system can propose the frequency, tidal volume, F i O 2 and pressure support/volume support parameters by an accuracy rate of 98,44% on simulations and an accuracy rate of 95,3% on field tests. The incorrect suggestions has small deviance to optimum values, which are harmless to patients in case of application.
The training of the ANN in the system has been realized with the physiological data from 158 patients. The rate of accuracy in the system’s prediction capability will increase with the use of data from higher number of patients. Thus, non-physician operators will also be able to use the system towards the determination of the ventilator settings in case of emergencies.
Improvement of the project as an automation system can be provided by the transmission of the physiological values of the patients to our decision support system from the hospital database and the direct installment of the treatment parameters preferred by the system in the ventilator device, without a mediator. For further studies we are going to identify the parameters which have less impact on results. Elimination of these parameters will speed-up the execution periods.
We would like to extend our sincerest appreciation to all medical staff who participated in this study for their invaluable support, especially Dr. Cengiz Yumlu, MD. To request the dataset used in this article, please contact with FPA. This work was partially supported by The Research Fund of The University of Istanbul. Project numbers: 3898, IRP-11824 and UDP-25231.
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