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Table 4 Subgroup analysis based on acute kidney renal disease (AKI) status

From: Effect of early serum phosphate disorder on in-hospital and 28-day mortality in sepsis patients: a retrospective study based on MIMIC-IV database

Outcome

Delta serum phosphate level during the first 3 days of ICU admission (mg/dL)

 

0−1.3

1.4−2.0

2.1–3.1

≥ 3.2

AKI during hospitalization(n = 538)

N

91

126

136

185

In-hospital mortality

32 (35.16)

41 (32.54)

37 (27.21)

73 (39.46)

Mortality, OR (95% CI, P)

    

-Model 1, unadjusted

1.0 (Ref)

0.89 (0.50,1.58), 0.686

0.69 (0.39,1.22), 0.202

1.20 (0.72,2.04), 0.490

-Model 2a

1.0 (Ref)

0.93 (0.52,1.65), 0.797

0.71 (0.40,1.26), 0.237

1.35 (0.80,2.31), 0.272

-Model 3b

1.0 (Ref)

0.99 (0.55,1.80), 0.969

0.80 (0.44,1.48), 0.479

1.47 (0.81,2.67), 0.206

28-day mortality

39 (42.86)

47 (37.30)

41 (30.15)

84 (45.41)

Mortality, OR (95% CI, P)

    

-Model 1, unadjusted

1.0 (Ref)

0.79 (0.46,1.38), 0.409

0.58 (0.33,1.00), 0.05

1.11 (0.67,1.85), 0.689

-Model 2a

1.0 (Ref)

0.83 (0.48,1.44), 0.506

0.58 (0.33,1.02), 0.057

1.21 (0.72,2.03), 0.471

-Model 3b

1.0 (Ref)

0.91 (0.51,1.61), 0.736

0.66 (0.37,1.19), 0.168

1.30 (0.74,2.32), 0.363

No AKI during hospitalization(n = 837)

N

202

229

234

172

In-hospital mortality

38 (18.81)

59 (25.76)

67 (28.63)

56 (32.56)

Mortality, OR (95% CI, P)

    

-Model 1, unadjusted

1.0 (Ref)

1.50 (0.95,2.39), 0.086

1.73 (1.11, 2.74), 0.017

2.08 (1.30,3.37), 0.002

-Model 2a

1.0 (Ref)

1.49 (0.94,2.38), 0.094

1.78 (1.13,2.83), 0.013

2.26 (1.40,3.68), < 0.001

-Model 3b

1.0 (Ref)

1.43 (0.88,2.34), 0.148

1.70 (1.04,2.81), 0.035

1.65 (0.95,2.90), 0.078

28-day mortality

50 (24.75)

75 (32.75)

78 (33.33)

66 (38.37)

Mortality, OR (95% CI, P)

    

-Model 1, unadjusted

1.0 (Ref)

1.48 (0.97,2.27), 0.069

1.52 (1.00,2.32), 0.050

1.89 (1.22,2.96), 0.005

-Model 2a

1.0 (Ref)

1.48 (0.97,2.28), 0.073

1.57 (1.03,2.42), 0.038

2.11 (1.34,3.33), 0.001

-Model 3b

1.0 (Ref)

1.40 (0.90,2.20), 0.142

1.47 (0.93,2.35), 0.101

1.48 (0.87,2.51), 0.146

  1. a: Adjusted for sex and age
  2. b: Adjusted for sex, age, infection site, intestine disease, invasive mechanical ventilation time, APACHEII score, PH, creatinine