Table 2 Odds ratios of risk of Sjögren’s disease diagnosis according to conditional logistic regression models

Conditional Logistic Regression Model Based on EHR Data

Drug Class: Antimalarials

1.88 (0.18, 19.51)

0.598

Drug Class: Glucocorticosteroids

1.36 (0.62, 2.97)

0.448

Drug Class: Nonsteroidal Anti-inflammatory Agents (NSAIDs)

1.23 (0.62, 2.45)

0.555

Drug Class: Throat Products - Misc.

13.14 (2.49, 69.26)

0.002

Diagnosis: Depressive disorder

1.29 (0.62, 2.66)

0.494

Diagnosis: Myalgia and myositis/Fibromyalgia

1.79 (0.71, 4.53)

0.215

Diagnosis: Pain in joints

2.36 (1.27, 4.37)

0.006

Diagnosis: Systemic lupus erythematosus

2.60 (0.30, 22.27)

0.382

Diagnosis: Tear Film Insufficiency

32.35 (6.21, 168.63)

< 0.001

Laboratory Test: Rheumatoid Factor

7.09 (2.02, 24.81)

0.002

Dry Mouth

6.91 (2.41, 19.82)

< 0.001

Conditional Logistic Regression Model Based on Integrated EHR and EDR Data

Drug Class: Antimalarials

2.10 (0.18, 24.03)

0.552

Drug Class: Glucocorticosteroids

1.66 (0.74, 3.75)

0.223

Drug Class: Nonsteroidal Anti-inflammatory Agents (NSAIDs)

1.15 (0.57, 2.34)

0.699

Drug Class: Throat Products - Misc.

14.97 (2.70, 83.06)

0.002

Diagnosis: Myalgia and myositis/Fibromyalgia

1.50 (0.58, 3.90)

0.403

Diagnosis: Pain in joints

2.53 (1.34, 4.76)

0.004

Diagnosis: Systemic lupus erythematosus

2.17 (0.23, 20.15)

0.496

Diagnosis: Tear Film Insufficiency

27.04 (5.37, 136.26)

< 0.001

Dental Procedure: Diagnostic

0.45 (0.20, 1.01)

0.053

Dental Procedure: Surgery

2.33 (1.14, 4.78)

0.021

Laboratory Test: Rheumatoid Factor

6.97 (1.94, 25.12)

0.003

Dry Mouth

6.19 (2.14, 17.89)

< 0.001