Table 1 Baseline data for this study

Age, (years)

66.27 ± 12.25

69.82 ± 11.74

63.12 ± 11.85

P < 0.0001

Gender,n(%)

 Femal

224(35.8)

102(34.7)

122(36.7)

P = 0.593

 Body mass index, (kg/m²)

23.04 ± 23.93

22.46 ± 3.51

23.55 ± 4.21

P < 0.0001

 Heart rate,(beat/minute)

85.46 ± 21.69

86.46 ± 20.49

84.58 ± 22.70

P = 0.282

 PR interval (ms)

167.25 ± 37.18

169.25 ± 40.95

165.56 ± 33.62

P = 0.231

 Heart rate-corrected QT interval (ms)

458.25 ± 44.52

459.01 ± 44.73

457.58 ± 44.39

P = 0.690

 QRS width (ms)

118.52 ± 32.88

119.54 ± 32.01

116.52 ± 31.83

P = 0.062

 Left ventricular ejection fraction (LVEF,%)

44.71 ± 16.45

43.66 ± 16.74

45.64 ± 16.15

P = 0.133

 Left ventricular end Diastolic diameter (mm)

57.04 ± 13.06

56.71 ± 13.21

57.32 ± 12.93

P = 0.565

 Left atrial diameter (mm)

42.72 ± 9.92

43.461 ± 0.70

42.0 ± 79.05

P = 0.081

 Systolic blood pressure, (mmHg)

121.77 ± 22.78

119.59 ± 23.22

121.77 ± 22.78

P = 0.024

 Diastolic blood pressure, (mmHg)

76.48 ± 15.27

74.13 ± 15.47

78.57 ± 14.80

P < 0.0001

 Hypertension, n(%)

319(51)

150(51)

169(50.9)

P = 0.977

 Diabetes mellitus, n(%)

168(26.8)

90(30.6)

78(23.5)

P = 0.045

 Coronary heart disease, n(%)

315(50.3)

152(51.7)

163(49.1)

P = 0.515

 History of stroke, n(%)

75(12.0)

40(13.6)

36(10.5)

P = 0.239

 Atrial fibrillation, n(%)

204(32.6)

104(35.4)

100(30.1)

 CRT/D(%)

67(10.7)

40(13.6)

27(8.1)

P = 0.027

 Smoking status, n(%)

231(36.9)

108(36.7)

123(37)

P = 0.935

 drinking status, n(%)

117(18.7)

49(16.7)

68(20.5)

P = 0.222

 Number of hospitalizations(times)

3(2,4)

4(3,4)

3(2,4)

P = 0.028

Laboratory data

 Troponin (ng/ml)

0.05(0.03,0.06)

0.05(0.03,0.08)

0.04(0.03,0.05)

P = 0.025

 Albumin, (g/dL)

37.21 ± 4.52

36.71 ± 4.74

37.65 ± 4.26

P = 0.009

 LgBNP

1.31(0.81,2.13)

1.97(0.54,2.97)

1.11(0.74,1.78)

P < 0.0001

 Creatinine, (μmol/L)

102.65(83.5,133.35)

109.5(88.5,141.3)

97.9(80.2,122.9)

P < 0.0001

 Uric acid,(umol/L)

476.8(373.7,579.8)

441.5(396.5,614.1)

457.5(357,551.4)

P < 0.0001

 Serum urea (mmol/L)

7.32(5.60,10.37)

7.98(5.91,12.2)

6.80(5.44,9.24)

P < 0.0001

 Glomerular filtration rate,(ml/min)

44.97(32.51,56.62)

40.88(21.2,52.56)

48.46(36.54,60.05)

P < 0.0001

 Triglyceride, (mmol/L)

1.30 ± 1.03

1.28 ± 1.32

1.33 ± 0.69

P = 0.555

 Total cholesterol, (mmol/L)

3.67 ± 1.01

3.55 ± 1.01

3.78 ± 0.99

P = 0.004

 HDLC, (mmol/L)

1.00 ± 0.33

0.98 ± 0.35

1.02 ± 1.31

P = 0.160

 LDLC, (mmol/L)

2.26 ± 0.83

2.15 ± 0.83

2.35 ± 0.83

P = 0.003

 Potassium,(mmol/L)

3.9(3.59,4.25)

3.91(3.59,4.3)

3.88(3.59,4.23)

P = 0.339

 Sodium,(mmol/L)

140.59 ± 5.80

139.83 ± 4.67

141.26 ± 6.58

P = 0.002

 chlorine,(mmol/L)

102.7(99.5,105.7)

102.1(98.1, 105.4)

103.35(100.4,105.8)

P < 0.0001

 WBC,(10^9/L)

6.82(5.51,8.66)

6.91(5.51,9.02)

6.70(5.53,8.44)

P = 0.670

 Neutrophil, (10^9/L)

4.47(3.50,6.12)

4.67(3.49,6.5)

4.35(3.52,5.71)

P = 0.196

 Lymphocyte, (10^9/L)

1.51 ± 0.78

1.41 ± 0.80

1.60 ± 0.75

P = 0.003

 RBC,(10^12/L)

4.61 ± 0.74

4.48 ± 0.78

4.72 ± 0.69

P < 0.0001

 Hemoglobin,(g/L)

141(126,155)

139(120,152.9)

144(129,156)

P = 0.001

 RBC volume distribution width

14.74 ± 1.95

12.35 ± 1.78

13.06 ± 1.83

P = 0.307

 Platelet volume distribution width

13.98 ± 3.00

12.08 ± 2.47

13.15 ± 3.18

P = 0.958

NYHA classification, n (%)

 Class IV

228(36.4)

143(48.6)

85(25.6)

P < 0.0001

Treatment, n (%)

 ACE-I or ARB or ARNI

501(80.9)

231(88.3)

270(83.2)

P = 0.670

 Beta blockers

489(79.1)

210(85.6)

279(81.7)

P = 0.745

 Diuretics

501(80.9)

231(88.3)

270(78.5)

P = 0.822

 Aldosterone antagonist

389(62.2)

181(61.5)

208(50.1)

P = 0.694