A generalizable and interpretable model for mortality risk stratification of sepsis patients in intensive care unit

Table 4 Reclassification table

External Validation	Initial Model		Predicted probability according to initial model			Reclassified (%)	Statistics
External Validation	Initial Model		< 5%	5–42%	> 42%	Reclassified (%)	NRI (95% CI)	p-value
MIMIC-IV	OASIS	< 5%	1026	807	166	49	0.789 (0.754–0.825)	< 0.0001
		5–42%	5592	4400	929	61
		> 42%	1185	837	190	91
	APS III	< 5%	1645	1193	253	47	0.773 (0.738–0.807)	< 0.0001
		5–42%	5682	4217	896	61
		> 42%	876	634	136	92
	SAPS II	< 5%	604	474	87	48	0.747 (0.710–0.784)	< 0.0001
		5–42%	5749	4194	897	61
		> 42%	1850	1376	301	91
	LODS	< 5%	463	340	60	46	0.830 (0.796–0.864)	< 0.0001
		5–42%	6959	5138	1089	61
		> 42%	781	566	136	91
	SIRS	< 5%	0	0	0	-	0.909 (0.876–0.941)	< 0.0001
		5–42%	8203	6044	1285	61
		> 42%	0	0	0	-
	SOFA	< 5%	893	663	151	48	0.848 (0.815–0.881)	< 0.0001
		5–42%	7125	5229	1101	61
		> 42%	185	152	33	91
eICU	SAPS III	< 5%	3649	3776	490	54	0.571 (0.542–0.600)	< 0.0001
		5–42%	5303	5412	690	53
		> 42%	365	351	43	94
	APACHE IV	< 5%	1824	1918	247	54	0.560 (0.526–0.594)	< 0.0001
		5–42%	5502	5664	733	52
		> 42%	1213	1185	159	94
	SOFA	< 5%	1822	1781	239	53	0.636 (0.609–0.663)	< 0.0001
		5–42%	8776	8776	1141	53
		> 42%	30	46	6	93
Zigong	SIRS	< 5%	0	0	0	-	0.318 (0.258–0.379)	< 0.001
		5–42%	29	690	479	42
		> 42%	0	0	0	-
	SOFA	< 5%	0	0	0	-	0.304 (0.244–0.365)	< 0.0001
		5–42%	29	687	459	42
		> 42%	0	3	20	13

NRI net reclassification improvement, OASIS Oxford acute severity of illness score, APS III Acute Physiology Score III, APACHE IV Acute Physiology, Age, Chronic Health Evaluation IV

ISSN: 1472-6947