Table 2 Details of the features used on the ADNI and NACC datasets
From: XGBoost-SHAP-based interpretable diagnostic framework for alzheimer’s disease
Features | ADNI | NACC |
|---|---|---|
Demographic information | AGE (Subject’s age) | NACCAGE |
PTGENDER (Subject’s sex) | SEX | |
PTEDUCAT (Years of education) | EDUC | |
PTMARRY (Marital status) | MARISTAT | |
Gene | APOE4 (Number of APOE-ε4 alleles) | |
Neuropsychological tests | ADAS11 (Alzheimer’s Disease Assessment Scale-Cognition 11 items) | |
ADAS13 (Alzheimer’s Disease Assessment Scale-Cognition 13 items) | ||
ADASQ4 (Score from Task 4 (Word Recognition) of the Alzheimer’s Disease Assessment Scale) | ||
MMSE (Total Score of Mini-Mental State Examination) | NACCMMSE | |
FAQ (Total Score of Functional Activities Questionnaire) | FAQ-sum | |
MOCA (Total Score of Montreal Cognitive Assessment) | ||
CDRSB (Clinical Dementia Rating-Sum of Boxes Score) | CDRGLOB | |
RAVLT_immediate (Rey’s Auditory Verbal Learning Test_Immediate Recall) | ||
RAVLT_learning (Rey’s Auditory Verbal Learning Test_Learning) | ||
RAVLT_forgetting (Rey’s Auditory Verbal Learning Test_Forgetting) | ||
RAVLT_perc_forgetting (Rey’s Auditory Verbal Learning Test_Percent Forgetting) | ||
LDELTOTAL (Delayed total recall) | MEMUNITS | |
TRABSCOR (Trail Making Test Part B Time) | ||
mPACCdigit (Modified Preclinical Alzheimer Cognitive Composite with Digit test) | ||
mPACCtrailsB (Modified Preclinical Alzheimer Cognitive Composite with Trails test) | ||
Neuroimaging-extracted biomarkers | Ventricles (Volume of ventricles) | LATVENT + HIRVENT |
Hippocampus (Volume of hippocampus) | ||
WholeBrain (Volume of Whole Brain) | ||
Entorhinal (Volume of entorhinal) | ||
Fusiform (Volume of fusiform) | ||
MidTemp (Volume of middle temporal gyrus) | ||
ICV (Volume of intracranial) |