Prognostic models for breast cancer: based on logistics regression and Hybrid Bayesian Network

Su, Fan; Chao, Jianqian; Liu, Pei; Zhang, Bowen; Zhang, Na; Luo, Zongyu; Han, Jiaying

doi:10.1186/s12911-023-02224-1

BMC Medical Informatics and Decision Making

Table 4 LR model for predicting survival outcomes

From: Prognostic models for breast cancer: based on logistics regression and Hybrid Bayesian Network

Characteristics	\(\beta\)	\({s}_{\stackrel{-}{x}}\)	Wald \({\chi }^{2}\)	OR [95%CI]	p value
Age	-0.006	0.001	-5.540	0.994 [0.992, 0.996]	< 0.001^***
Tumor Size (mm)	0.001	0.001	1.665	1.001 [1.000, 1.003]	\(<\)0.001^***
Radiation
Beam radiation				1.000
Radioactive implants	0.639	0.097	6.565	1.895 [1.565,2.292]	\(<\)0.001^***
Others	0.105	0.026	4.078	1.110 [1.056,1.168]	\(<\)0.001^***
Surg
No				1.000
Yes	-0.881	0.039	-22.842	0.414 [0.384, 0.447]	\(<\)0.001^***
Chemotherapy
No				1.000
Yes	0.207	0.030	6.974	1.230 [1.161, 1.304]	\(<\)0.001^***
Nodes
0				1.000
1	-0.127	0.032	-3.901	0.881 [0.827, 0.939]	< 0.001^***
2	0.059	0.072	0.818	1.061 [0.920, 1.221]	0.414
3	0.371	0.048	7.735	1.449 [1.319, 1.592]	< 0.001^***
4	0.296	0.042	7.047	1.345 [1.239, 1.461]	< 0.001^***
5	-0.238	0.164	-1.452	0.788 [0.569, 1.082]	0.146
6	0.790	0.183	4.327	2.203 [1.539, 3.151]	< 0.001^***
7	1.025	0.113	9.050	2.787 [2.238, 3.490]	< 0.001^***
8	-0.424	0.482	-0.880	0.655 [0.257, 1.707]	0.379
9	0.001	0.180	0.003	1.001 [0.703, 1.425]	0.997
10	0.771	0.125	6.183	2.161 [1.698, 2.769]	< 0.001^***
11	1.240	0.118	10.552	3.457 [2.756, 4.371]	< 0.001^***
12	0.573	0.135	4.237	1.773 [1.363, 2.316]	< 0.001^***
Mets
No distant metastasis				1.000
No evidence of distant mets	0.618	0.268	2.309	1.855 [1.094, 3.137]	0.021^*
Distant lymph node(s)	1.144	0.130	8.818	3.139 [2.447, 4.071]	< 0.001^***
Others	1.413	0.044	31.957	4.110 [3.770, 4.484]	< 0.001^***
Subtype
HR-/HER2-				1.000
h-/HER2+	-0.244	0.064	-3.804	0.783 [0.690, 0.888]	< 0.001^***
HR+/HER2-	-0.428	0.048	-8.895	0.652 [0.593, 0.716]	< 0.001^***
HR+/HER2+	-0.003	0.056	-0.050	0.997 [0.893, 1.114]	0.96
Stage
1 A				1.000
1B	-0.323	0.039	-8.227	0.724 [0.670, 0.782]	< 0.001^***
2 A	-0.497	0.049	-10.203	0.608 [0.553, 0.669]	< 0.001^***
2B	-0.698	0.065	-10.786	0.497 [0.438, 0.565]	< 0.001^***
3 A	-0.941	0.087	-10.851	0.390 [0.329, 0.462]	< 0.001^***
3B	-1.139	0.091	-12.552	0.320 [0.268, 0.382]	< 0.001^***
3 C	-1.292	0.116	-11.121	0.275 [0.218, 0.345]	< 0.001^***
4	1.192	0.046	25.926	3.294 [3.012, 3.606]	< 0.001^***
ER
Negative				1.000
Positive	-0.395	0.042	-9.476	0.674 [0.621, 0.731]	\(<\)0.001^***
PR
Negative				1.000
Positive	-0.258	0.032	-8.147	0.773 [0.726, 0.822]	\(<\)0.001^***
Histologic
8500				1.000
8507	1.725	0.152	11.381	5.614 [4.195, 7.607]	\(<\)0.001^***
8520 or 8521	0.644	0.038	17.015	1.904 [1.768, 2.051]	\(<\)0.001^***
8522	1.110	0.053	21.113	3.036 [2.739, 3.366]	\(<\)0.001^***
8523 or 8524	1.050	0.147	7.131	2.858 [2.143, 3.820]	\(<\)0.001^***
8530	2.872	0.218	13.148	17.675 [11.795, 27.880]	\(<\)0.001^***
Others	1.186	0.303	3.916	3.273 [1.833, 6.047]	\(<\)0.001^***
Grade
1				1.000
2	-0.094	0.036	-2.581	0.911 [0.848, 0.978]	0.01
3	-0.043	0.045	-0.957	0.957 [0.876, 1.047]	0.339
4	-0.028	0.043	-0.659	0.972 [0.894, 1.057]	0.51
Site
C501				1.000
C502	-0.379	0.064	-5.905	0.685 [0.604, 0.776]	< 0.001^***
C503	-0.349	0.077	-4.561	0.705 [0.607, 0.819]	< 0.001^***
C504	-0.217	0.057	-3.785	0.805 [0.719, 0.901]	< 0.001^***
C505	-0.572	0.072	-7.898	0.564 [0.489, 0.650]	< 0.001^***
C508	-0.309	0.059	-5.208	0.734 [0.653, 0.825]	< 0.001^***
C509	0.101	0.064	1.591	1.107 [0.977, 1.254]	0.112
Race
White				1.000
Black	0.620	0.036	17.003	1.859 [1.731, 1.997]	\(<\)0.001^***
Others	0.246	0.033	7.368	1.279 [1.198, 1.365]	\(<\)0.001^***
Marital
Married				1.000
Divorced	0.166	0.040	4.169	1.181 [1.092, 1.276]	\(<\)0.001^***
Separated	0.685	0.113	6.053	1.985 [1.592, 2.483]	\(<\)0.001^***
Single	0.427	0.032	13.327	1.532 [1.439, 1.631]	\(<\)0.001^***
Unmarried or Domestic Partner	0.203	0.119	1.704	1.224 [0.969, 1.545]	0.088
Widowed	0.042	0.044	0.942	1.043 [0.956, 1.137]	0.346
Laterality
Left - origin of primary				1.000
Right - origin of primary	0.089	0.024	3.674	1.094 [1.043, 1.147]	\(<\)0.001^***

^* means P \(\le\) 0.05; ^** means P \(\le\) 0.01; ^*** means P \(\le\) 0.001
Surg, Primary Site Surgery; Nodes, Lymph Node; Mets, Distant Metastasis; ER, Estrogen Receptor; PR, Progesterone Receptor; Histologic, Histologic Type; Site, Primary Site

Back to article page

ISSN: 1472-6947

Contact us

General enquiries: journalsubmissions@springernature.com