Table 4 Conversion of typical disease names to UDS
Typical disease name | e | o | p |
|---|---|---|---|
Wilson’s disease | ATP7B gene mutation | 1.hepatocyte lysis, hypoplasia and hyposecretion 2.iris edge 3.lenticular nucleus degeneration and hypofunction | 1.IR4, cirrhosisa, metabolic pathogenesis (hypoceruloplasminemia, hypoalbuminemia, hyperbilirubinemia, … 2.Copper precipitate 3.Neural pathways |
Huntington's disease | dominant huntingtin gene hyperconcatenation of cytosine-adenine-guanine (CAG) repeats | 1.striatal degeneration and atrophy 2.hypocognition, 3.psychosis, compulsions, aggression,… 4.Huntingtin with > 36 glutamine residues | 1.cortical brain-derived neurotrophic factor (BDNF) depletion 2a. dyskinesia 2b. late behavioral hypoactivity |
multiple sclerosis | 1.essential 2.Epstein-Barr virus | Central nervous demyelination and nerve cell hypofunction | IR4a |