Table 1 The list of a priori selected features and their respective feature clusters

Demographics

Sex at birth (male, female), age at index date

All

Race/ethnicity

Hispanic, Asian, Black or African American, White

All

Comorbidities

Hypertension, renal disease, liver disease, cerebrovascular disease, bleeding disorder, organ transplant

All

Bleeding history

History of bleeding

All

Socioeconomic

Highest education level achieved (no high school degree, high school graduate, college 1–3 years, college 4 or more years or advanced degree), employed for wages or self-employed, annual household income (< 10 k, 10-25 k, 25-35 k, 35-50 k, 50-75 k, 75-100 k, 100-150 k, 150-200 k, ≥ 200 k), health insurance

All

Alcohol use

At least once: alcohol drinking

All

Smoking

100 cigarettes lifetime

At least once: cigar smoking, electronic smoking, hookah smoking, smokeless tobacco

All

Recreational drug use

At least once: cocaine, hallucinogens, inhalants, marijuana, methamphetamine, prescription opioids, stimulants, sedatives, street opioids

All

Concurrent drug use: antithrombotics

Clopidogrel, warfarin, apixaban, rivaroxaban, dabigatran, edoxaban, ticagrelor, prasugrel, dipyridamole, ticlopidine, eptifibatide, aspirin (low dose)

All

Concurrent drug use: non-steroidal anti-inflammatory drugs (NSAIDs)

Aspirin (high dose), ibuprofen, indomethacin, naproxen, mefenamic acid, ketorolac, meloxicam, celecoxib, diclofenac

All

Concurrent drug use: glucocorticoids

Prednisone, prednisolone, methylprednisolone, dexamethasone, hydrocortisone

All

Health literacy

Brief Health Literacy Screen

All

Current SSRI use

Citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, vortioxetine

Combined SSRIs models

SSRI used just before the newly prescribed SSRI

None, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, vortioxetine

Combined SSRIs models

Number of prior SSRI switches

Number of switches

Combined SSRIs models