Construction of the XGBoost model for early lung cancer prediction based on metabolic indices

Guan, Xiuliang; Du, Yue; Ma, Rufei; Teng, Nan; Ou, Shu; Zhao, Hui; Li, Xiaofeng

doi:10.1186/s12911-023-02171-x

BMC Medical Informatics and Decision Making

Table 1 Sociodemographic and pathological characteristics of patients and controls in the case and control groups in the training and validation sets

From: Construction of the XGBoost model for early lung cancer prediction based on metabolic indices

	Trainning Set			Validation Set
	Cancer (339)	Cotrol (254)	P	Cancer (139)	Cotrol (116)	P
Gen, No.(%)			0.001			0.702
Male	127(37.5)	131(51.6)		59(42.4)	52(44.8)
Female	212(62.5)	1283(48.4)		80(57.6)	64(55.2)
Age, yrs	62.22 ± 10.27	56.26 ± 11.43	0.000	61.82 ± 10.67	53.41 ± 12.07	0.000
Mean ± SD	62.22 ± 10.27	56.26 ± 11.43	0.000	61.82 ± 10.67	53.41 ± 12.07	0.000
Ala	195.4 ± 52.89	203.93 ± 59.92	0.000	189.21 ± 56.61	206.81 ± 61.2	0.000
Mean ± SD	195.4 ± 52.89	203.93 ± 59.92	0.000	189.21 ± 56.61	206.81 ± 61.2	0.000
Arg	4.83 ± 3.5	6.27 ± 5.24	0.067	5.5 ± 4.63	5.56 ± 4.27	0.018
Mean ± SD	4.83 ± 3.5	6.27 ± 5.24	0.067	5.5 ± 4.63	5.56 ± 4.27	0.018
Asn	66.42 ± 16.45	72.65 ± 18.97	0.072	68.91 ± 18.58	70.03 ± 17.27	0.019
Mean ± SD	66.42 ± 16.45	72.65 ± 18.97	0.072	68.91 ± 18.58	70.03 ± 17.27	0.019
Asp	31.4 ± 14.54	40.18 ± 17.67	0.000	32.1 ± 15.4	39.55 ± 17.64	0.925
Mean ± SD	31.4 ± 14.54	40.18 ± 17.67	0.000	32.1 ± 15.4	39.55 ± 17.64	0.925
Cit	25.87 ± 7.16	22.99 ± 7.28	0.000	26.44 ± 8.22	22.15 ± 6.95	0.925
Mean ± SD	25.87 ± 7.16	22.99 ± 7.28	0.000	26.44 ± 8.22	22.15 ± 6.95	0.925
Gln	10.26 ± 4.55	9.4 ± 3.61	0.000	10.27 ± 4.15	9.37 ± 3.38	0.621
Mean ± SD	10.26 ± 4.55	9.4 ± 3.61	0.000	10.27 ± 4.15	9.37 ± 3.38	0.621
Glu	146.52 ± 38.69	133.67 ± 33.96	0.000	144.5 ± 35.55	129.74 ± 31.03	0.619
Mean ± SD	146.52 ± 38.69	133.67 ± 33.96	0.000	144.5 ± 35.55	129.74 ± 31.03	0.619
Gly	179.65 ± 41.9	179.33 ± 42.59	0.000	181.64 ± 41.06	174.28 ± 43.51	0.000
Mean ± SD	179.65 ± 41.9	179.33 ± 42.59	0.000	181.64 ± 41.06	174.28 ± 43.51	0.000
His	75.29 ± 43.09	71.05 ± 32.7	0.000	71.91 ± 42.25	73.28 ± 31.24	0.000
Mean ± SD	75.29 ± 43.09	71.05 ± 32.7	0.000	71.91 ± 42.25	73.28 ± 31.24	0.000
Leu	104.1 ± 23.58	106.15 ± 29.92	0.000	107.6 ± 28.19	103.5 ± 30.81	0.000
Mean ± SD	104.1 ± 23.58	106.15 ± 29.92	0.000	107.6 ± 28.19	103.5 ± 30.81	0.000
Lys	168 ± 73.21	167.19 ± 73.85	0.000	165.55 ± 73.86	169.37 ± 64.23	0.000
Mean ± SD	168 ± 73.21	167.19 ± 73.85	0.000	165.55 ± 73.86	169.37 ± 64.23	0.000
Met	15.12 ± 4.81	14.89 ± 5.32	0.013	15.51 ± 5.12	14.33 ± 3.3	0.061
Mean ± SD	15.12 ± 4.81	14.89 ± 5.32	0.013	15.51 ± 5.12	14.33 ± 3.3	0.061
Orn	14.83 ± 9.17	22.96 ± 11.99	0.010	15.68 ± 11.14	22.46 ± 11.68	0.056
Mean ± SD	14.83 ± 9.17	22.96 ± 11.99	0.010	15.68 ± 11.14	22.46 ± 11.68	0.056
Phe	41.49 ± 9.04	42.44 ± 12.22	0.000	43.18 ± 11.44	42.37 ± 11.06	0.001
Mean ± SD	41.49 ± 9.04	42.44 ± 12.22	0.000	43.18 ± 11.44	42.37 ± 11.06	0.001
Pro	476.59 ± 185.44	426.43 ± 158.47	0.000	486.87 ± 211.1	406.62 ± 158.33	0.000
Mean ± SD	476.59 ± 185.44	426.43 ± 158.47	0.000	486.87 ± 211.1	406.62 ± 158.33	0.000
Ser	48.25 ± 10.55	54.29 ± 13.91	0.925	49.87 ± 12.67	53.44 ± 14.59	0.167
Mean ± SD	48.25 ± 10.55	54.29 ± 13.91	0.925	49.87 ± 12.67	53.44 ± 14.59	0.167
Thr	26.4 ± 9.1	34.12 ± 13.05	0.925	26.34 ± 9.15	32.19 ± 12.32	0.169
Mean ± SD	26.4 ± 9.1	34.12 ± 13.05	0.925	26.34 ± 9.15	32.19 ± 12.32	0.169
Trp	44.28 ± 10.95	47.62 ± 11.1	0.191	43.63 ± 11.42	47.33 ± 11.38	0.774
Mean ± SD	44.28 ± 10.95	47.62 ± 11.1	0.191	43.63 ± 11.42	47.33 ± 11.38	0.774
Tyr	56.84 ± 14.74	49.84 ± 15.22	0.174	57.78 ± 15.73	49.94 ± 12.69	0.768
Mean ± SD	56.84 ± 14.74	49.84 ± 15.22	0.174	57.78 ± 15.73	49.94 ± 12.69	0.768
Val	148.66 ± 30.17	137.38 ± 32.13	0.352	149.07 ± 32.1	137.52 ± 28.7	0.270
Mean ± SD	148.66 ± 30.17	137.38 ± 32.13	0.352	149.07 ± 32.1	137.52 ± 28.7	0.270
C0	26.27 ± 7.17	26.19 ± 6.91	0.368	27.81 ± 8.77	25.49 ± 7.21	0.273
Mean ± SD	26.27 ± 7.17	26.19 ± 6.91	0.368	27.81 ± 8.77	25.49 ± 7.21	0.273
C2	13.9 ± 4.06	14.01 ± 4.52	0.894	14.73 ± 4.84	14.3 ± 4.69	0.664
Mean ± SD	13.9 ± 4.06	14.01 ± 4.52	0.894	14.73 ± 4.84	14.3 ± 4.69	0.664
C3	1.61 ± 0.65	1.59 ± 0.67	0.894	1.65 ± 0.68	1.59 ± 0.74	0.660
Mean ± SD	1.61 ± 0.65	1.59 ± 0.67	0.894	1.65 ± 0.68	1.59 ± 0.74	0.660
C4	0.19 ± 0.08	0.18 ± 0.08	0.584	0.2 ± 0.1	0.18 ± 0.09	0.034
Mean ± SD	0.19 ± 0.08	0.18 ± 0.08	0.584	0.2 ± 0.1	0.18 ± 0.09	0.034
C4OH	0.04 ± 0.02	0.06 ± 0.04	0.590	0.05 ± 0.04	0.06 ± 0.04	0.028
Mean ± SD	0.04 ± 0.02	0.06 ± 0.04	0.590	0.05 ± 0.04	0.06 ± 0.04	0.028
C4DC	0.3 ± 0.15	0.4 ± 0.2	0.000	0.3 ± 0.15	0.38 ± 0.17	0.000
Mean ± SD	0.3 ± 0.15	0.4 ± 0.2	0.000	0.3 ± 0.15	0.38 ± 0.17	0.000
C5	0.12 ± 0.05	0.13 ± 0.09	0.000	0.11 ± 0.05	0.12 ± 0.05	0.000
Mean ± SD	0.12 ± 0.05	0.13 ± 0.09	0.000	0.11 ± 0.05	0.12 ± 0.05	0.000
C5OH	0.18 ± 0.08	0.21 ± 0.1	0.281	0.17 ± 0.08	0.2 ± 0.08	0.568
Mean ± SD	0.18 ± 0.08	0.21 ± 0.1	0.281	0.17 ± 0.08	0.2 ± 0.08	0.568
C5DC	0.09 ± 0.05	0.1 ± 0.07	0.301	0.09 ± 0.05	0.1 ± 0.09	0.567
Mean ± SD	0.09 ± 0.05	0.1 ± 0.07	0.301	0.09 ± 0.05	0.1 ± 0.09	0.567
C51	0.03 ± 0.02	0.04 ± 0.02	0.001	0.03 ± 0.02	0.04 ± 0.03	0.001
Mean ± SD	0.03 ± 0.02	0.04 ± 0.02	0.001	0.03 ± 0.02	0.04 ± 0.03	0.001
C6	0.08 ± 0.05	0.08 ± 0.04	0.000	0.08 ± 0.03	0.08 ± 0.03	0.001
Mean ± SD	0.08 ± 0.05	0.08 ± 0.04	0.000	0.08 ± 0.03	0.08 ± 0.03	0.001
C6DC	0.38 ± 0.29	0.32 ± 0.35	0.000	0.41 ± 0.31	0.27 ± 0.34	0.038
Mean ± SD	0.38 ± 0.29	0.32 ± 0.35	0.000	0.41 ± 0.31	0.27 ± 0.34	0.038
C8	0.11 ± 0.12	0.1 ± 0.07	0.000	0.1 ± 0.06	0.1 ± 0.06	0.040
Mean ± SD	0.11 ± 0.12	0.1 ± 0.07	0.000	0.1 ± 0.06	0.1 ± 0.06	0.040
C10	0.11 ± 0.09	0.1 ± 0.08	0.000	0.1 ± 0.08	0.1 ± 0.06	0.000
Mean ± SD	0.11 ± 0.09	0.1 ± 0.08	0.000	0.1 ± 0.08	0.1 ± 0.06	0.000
C12	0.07 ± 0.03	0.06 ± 0.04	0.000	0.07 ± 0.03	0.06 ± 0.03	0.000
Mean ± SD	0.07 ± 0.03	0.06 ± 0.04	0.000	0.07 ± 0.03	0.06 ± 0.03	0.000
C14	0.06 ± 0.02	0.06 ± 0.02	0.000	0.06 ± 0.03	0.06 ± 0.02	0.010
Mean ± SD	0.06 ± 0.02	0.06 ± 0.02	0.000	0.06 ± 0.03	0.06 ± 0.02	0.010
C14OH	0.03 ± 0.02	0.03 ± 0.03	0.000	0.03 ± 0.01	0.03 ± 0.02	0.010
Mean ± SD	0.03 ± 0.02	0.03 ± 0.03	0.000	0.03 ± 0.01	0.03 ± 0.02	0.010
C14DC	0.03 ± 0.02	0.03 ± 0.02	0.000	0.03 ± 0.02	0.03 ± 0.02	0.000
Mean ± SD	0.03 ± 0.02	0.03 ± 0.02	0.000	0.03 ± 0.02	0.03 ± 0.02	0.000
C141	0.08 ± 0.04	0.08 ± 0.04	0.000	0.08 ± 0.04	0.07 ± 0.03	0.000
Mean ± SD	0.08 ± 0.04	0.08 ± 0.04	0.000	0.08 ± 0.04	0.07 ± 0.03	0.000
C16	0.93 ± 0.34	0.8 ± 0.29	0.000	0.93 ± 0.33	0.81 ± 0.3	0.003
Mean ± SD	0.93 ± 0.34	0.8 ± 0.29	0.000	0.93 ± 0.33	0.81 ± 0.3	0.003
C16OH	0.02 ± 0.01	0.03 ± 0.03	0.000	0.02 ± 0.01	0.03 ± 0.02	0.003
Mean ± SD	0.02 ± 0.01	0.03 ± 0.03	0.000	0.02 ± 0.01	0.03 ± 0.02	0.003
C161OH	0.04 ± 0.02	0.04 ± 0.02	0.883	0.04 ± 0.02	0.04 ± 0.02	0.024
Mean ± SD	0.04 ± 0.02	0.04 ± 0.02	0.883	0.04 ± 0.02	0.04 ± 0.02	0.024
C18	0.5 ± 0.18	0.49 ± 0.15	0.883	0.5 ± 0.16	0.5 ± 0.16	0.021
Mean ± SD	0.5 ± 0.18	0.49 ± 0.15	0.883	0.5 ± 0.16	0.5 ± 0.16	0.021
C20	0.02 ± 0.01	0.02 ± 0.02	0.763	0.02 ± 0.01	0.02 ± 0.02	0.473
Mean ± SD	0.02 ± 0.01	0.02 ± 0.02	0.763	0.02 ± 0.01	0.02 ± 0.02	0.473
C22	0.05 ± 0.03	0.06 ± 0.03	0.766	0.05 ± 0.03	0.06 ± 0.03	0.472
Mean ± SD	0.05 ± 0.03	0.06 ± 0.03	0.766	0.05 ± 0.03	0.06 ± 0.03	0.472
C24	0.03 ± 0.02	0.04 ± 0.02	0.679	0.04 ± 0.02	0.04 ± 0.02	0.458
Mean ± SD	0.03 ± 0.02	0.04 ± 0.02	0.679	0.04 ± 0.02	0.04 ± 0.02	0.458
C26	0.03 ± 0.01	0.03 ± 0.02	0.681	0.03 ± 0.01	0.03 ± 0.01	0.461
Mean ± SD	0.03 ± 0.01	0.03 ± 0.02	0.681	0.03 ± 0.01	0.03 ± 0.01	0.461

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