Table 1 The baseline of all patients
Variables | Overall | train set | test set | external validation set |
|---|---|---|---|---|
N = 2351 | n = 1568 | n = 673 | n = 110 | |
Age (median [IQR]) | 68.00 [59.00, 76.00] | 68.00 [59.00, 76.00] | 68.00 [60.00, 76.00] | 66.00 [57.25, 71.75] |
Laterality (%) | ||||
 left | 1248 (53.1) | 859 (54.8) | 338 (50.2) | 51 (46.4) |
 right | 1103 (46.9) | 709 (45.2) | 335 (49.8) | 59 (53.6) |
Grade (%) | ||||
 1 | 256 (10.9) | 178 (11.4) | 76 (11.3) | 2 (1.8) |
 2 | 1286 (54.7) | 826 (52.7) | 362 (53.8) | 98 (89.1) |
 3/4 | 809 (34.4) | 564 (36.0) | 235 (34.9) | 10 (9.1) |
AJCC.T (%) | ||||
 T0/Tis/T1 | 1081 (46.0) | 694 (44.3) | 311 (46.2) | 76 (69.1) |
 T2 | 970 (41.3) | 678 (43.2) | 259 (38.5) | 33 (30.0) |
 T2 | 68 (2.9) | 39 (2.5) | 28 (4.2) | 1 (0.9) |
 T4/TX | 232 (9.9) | 157 (10.0) | 75 (11.1) | 0 (0.0) |
AJCC.N (%) | ||||
 N0 | 1306 (55.6) | 893 (57.0) | 359 (53.3) | 54 (49.1) |
 N1 | 717 (30.5) | 460 (29.3) | 225 (33.4) | 32 (29.1) |
 N2 | 201 (8.5) | 131 (8.4) | 52 (7.7) | 18 (16.4) |
 N3/NX | 127 (5.4) | 84 (5.4) | 37 (5.5) | 6 (5.5) |
Radiotherapy (%) | ||||
 no | 1723 (73.3) | 1146 (73.1) | 474 (70.4) | 103 (93.6) |
 yes | 628 (26.7) | 422 (26.9) | 199 (29.6) | 7 (6.4) |
Chemotherapy (%) | ||||
 no | 1447 (61.5) | 979 (62.4) | 412 (61.2) | 56 (50.9) |
 yes | 904 (38.5) | 589 (37.6) | 261 (38.8) | 54 (49.1) |
Subtype (%) | ||||
 HR( +)/HER2(-) | 2038 (86.7) | 1355 (86.4) | 581 (86.3) | 102 (92.7) |
 HR( +)/HER2( +) | 259 (11.0) | 173 (11.0) | 79 (11.7) | 7 (6.4) |
 HR(-)/HER2(-) | 37 (1.6) | 27 (1.7) | 9 (1.3) | 1 (0.9) |
 HR(-)/HER2( +) | 17 (0.7) | 13 (0.8) | 4 (0.6) | 0 (0.0) |
ER (%) | ||||
 negative | 58 (2.5) | 43 (2.7) | 14 (2.1) | 1 (0.9) |
 positive | 2293 (97.5) | 1525 (97.3) | 659 (97.9) | 109 (99.1) |
PR (%) | ||||
 negative | 205 (8.7) | 140 (8.9) | 57 (8.5) | 8 (7.3) |
 positive | 2146 (91.3) | 1428 (91.1) | 616 (91.5) | 102 (92.7) |
HER2 (%) | ||||
 negative | 2075 (88.3) | 1382 (88.1) | 590 (87.7) | 103 (93.6) |
 positive | 276 (11.7) | 186 (11.9) | 83 (12.3) | 7 (6.4) |
bone metastasis (%) | ||||
 no | 2234 (95.0) | 1492 (95.2) | 637 (94.7) | 105 (95.5) |
 yes | 117 (5.0) | 76 (4.8) | 36 (5.3) | 5 (4.5) |
brain metastasis (%) | ||||
 no | 2336 (99.4) | 1560 (99.5) | 666 (99.0) | 110 (100.0) |
 yes | 15 (0.6) | 8 (0.5) | 7 (1.0) | 0 (0.0) |
liver metastasis (%) | ||||
 no | 2333 (99.2) | 1554 (99.1) | 670 (99.6) | 109 (99.1) |
 yes | 18 (0.8) | 14 (0.9) | 3 (0.4) | 1 (0.9) |
lung metastasis (%) | ||||
 no | 2280 (97.0) | 1530 (97.6) | 651 (96.7) | 99 (90.0) |
 yes | 71 (3.0) | 38 (2.4) | 22 (3.3) | 11 (10.0) |
Distant Metastasis (%) | ||||
 M0 | 2183 (92.9) | 1460 (93.1) | 627 (93.2) | 96 (87.3) |
 M1 | 168 (7.1) | 108 (6.9) | 46 (6.8) | 14 (12.7) |