Table 6 Summary of BC diagnosis performance (* denotes p-value < 0.05 of one metric within a feature rank)
From: Accurate breast cancer diagnosis using a stable feature ranking algorithm
| Â | Â | Â | n | AUC | ACC | SEN | SPE | NPV | F-measure | MCC |
|---|---|---|---|---|---|---|---|---|---|---|
BCDR-F03 | GFS | KNN | 3 | 0.61±0.04 | 0.60±0.04 | \({\textbf {0.62}}\!\varvec{\pm }\!{\textbf {0.08*}}\) | 0.59±0.06 | 0.80±0.04 | 0.47±0.03 | 0.46±0.05 |
LDA | 3 | 0.70±0.04 | 0.75±0.03 | 0.59±0.08 | 0.82±0.02 | \({\textbf {0.84}}\!\varvec{\pm }\!{\textbf {0.05}}\) | 0.57±0.03 | 0.54±0.04 | ||
NB | 4 | \({\textbf {0.71}}\!\varvec{\pm }\!{\textbf {0.04}}\) | 0.77±0.03 | 0.59±0.10 | 0.84±0.05 | 0.84±0.07 | \({\textbf {0.59}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | \({\textbf {0.58}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | ||
SVM | 2 | 0.70±0.03 | \({\textbf {0.78}}\!\varvec{\pm }\!{\textbf {0.03}}\) | 0.53±0.07 | \({\textbf {0.87}}\!\varvec{\pm }\!{\textbf {0.04*}}\) | 0.83±0.07 | 0.57±0.02 | 0.56±0.03 | ||
ANN01 | 2 | 0.65±0.05 | 0.72±0.03 | 0.52±0.09 | 0.83±0.03 | 0.81±0.09 | 0.52±0.03 | 0.51±0.03 | ||
ANN02 | 3 | 0.65±0.01 | 0.74±0.03 | 0.56±0.06 | 0.84±0.04 | 0.83±0.07 | 0.56±0.02 | 0.52±0.04 | ||
PWFP | KNN | 2 | 0.56±0.04 | 0.54±0.04 | 0.60±0.08 | 0.52±0.05 | 0.77±0.03 | 0.43±0.03 | 0.44±0.03 | |
LDA | 4 | 0.67±0.04 | 0.70±0.03 | \({\textbf {0.60}}\!\varvec{\pm }\!{\textbf {0.04}}\) | 0.74±0.05 | 0.82±0.03 | 0.53±0.06 | 0.50±0.04 | ||
NB | 4 | \({\textbf {0.68}}\!\varvec{\pm }\!{\textbf {0.05}}\) | 0.72±0.06 | 0.60±0.13 | 0.76±0.12 | \({\textbf {0.83}}\!\varvec{\pm }\!{\textbf {0.09}}\) | 0.54±0.03 | 0.51±0.04 | ||
SVM | 4 | 0.66±0.04 | \({\textbf {0.72}}\!\varvec{\pm }\!{\textbf {0.04}}\) | 0.52±0.07 | \({\textbf {0.80}}\!\varvec{\pm }\!{\textbf {0.06*}}\) | 0.81±0.09 | 0.51±0.02 | 0.50±0.03 | ||
ANN01 | 3 | 0.61±0.05 | 0.69±0.06 | 0.51±0.05 | 0.76±0.07 | 0.78±0.07 | 0.47±0.05 | 0.48±0.04 | ||
ANN02 | 4 | 0.64±0.03 | 0.71±0.03 | 0.55±0.03 | 0.78±0.04 | 0.81±0.04 | \({\textbf {0.55}}\!\varvec{\pm }\!{\textbf {0.03}}\) | \({\textbf {0.52}}\!\varvec{\pm }\!{\textbf {0.03}}\) | ||
LNEC | KNN | 3 | 0.60±0.04 | 0.60±0.04 | 0.58±0.08 | 0.61±0.06 | 0.79±0.04 | 0.45±0.03 | 0.43±0.04 | |
LDA | 3 | \({\textbf {0.69}}\!\varvec{\pm }\!{\textbf {0.04*}}\) | 0.70±0.04 | 0.67±0.07 | 0.71±0.05 | \({\textbf {0.84}}\!\varvec{\pm }\!{\textbf {0.05*}}\) | \({\textbf {0.56}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | \({\textbf {0.54}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | ||
NB | 3 | 0.63±0.04 | \({\textbf {0.72}}\!\varvec{\pm }\!{\textbf {0.05*}}\) | 0.43±0.15 | \({\textbf {0.83}}\!\varvec{\pm }\!{\textbf {0.10*}}\) | 0.79±0.07 | 0.45±0.03 | 0.44±0.04 | ||
SVM | 4 | 0.58±0.13 | 0.56±0.18 | 0.62±0.17 | 0.54±0.28 | 0.75±0.13 | 0.45±0.08 | 0.43±0.05 | ||
ANN01 | 3 | 0.56±0.01 | 0.69±0.03 | \({\textbf {0.69}}\!\varvec{\pm }\!{\textbf {0.04*}}\) | 0.72±0.04 | 0.78±0.03 | 0.52±0.04 | 0.50±0.04 | ||
ANN02 | 3 | 0.66±0.01 | 0.62±0.06 | 0.61±0.09 | 0.60±0.06 | 0.73±0.07 | 0.43±0.06 | 0.41±0.05 | ||
WDBC | GFS | KNN | 2 | 0.89±0.03 | 0.90±0.02 | 0.89±0.06 | 0.90±0.02 | 0.97±0.05 | 0.76±0.01 | 0.72±0.03 |
LDA | 2 | 0.93±0.02 | \({\textbf {0.95}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.90±0.05 | \({\textbf {0.96}}\!\varvec{\pm }\!{\textbf {0.01*}}\) | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.01}}\) | \({\textbf {0.87}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | \({\textbf {0.83}}\!\varvec{\pm }\!{\textbf {0.05}}\) | ||
NB | 2 | \({\textbf {0.94}}\!\varvec{\pm }\!{\textbf {0.02}}\) | 0.94±0.01 | \({\textbf {0.94}}\!\varvec{\pm }\!{\textbf {0.03*}}\) | 0.94±0.02 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.85±0.03 | 0.82±0.04 | ||
SVM | 2 | 0.92±0.02 | 0.92±0.01 | 0.91±0.05 | 0.93±0.02 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.81±0.03 | 0.80±0.05 | ||
ANN01 | 3 | 0.92±0.03 | 0.94±0.02 | 0.91±0.05 | 0.92±0.02 | 0.96±0.01 | 0.83±0.04 | 0.82±0.05 | ||
ANN02 | 2 | 0.92±0.03 | 0.93±0.03 | 0.89±0.05 | 0.91±0.03 | 0.95±0.01 | 0.80±0.05 | 0.78±0.03 | ||
PWFP | KNN | 3 | 0.87±0.03 | 0.89±0.02 | \({\textbf {0.85}}\!\varvec{\pm }\!{\textbf {0.06}}\) | 0.90±0.03 | 0.96±0.06 | 0.74±0.01 | 0.72±0.02 | |
LDA | 2 | 0.89±0.03 | \({\textbf {0.93}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.83±0.06 | \({\textbf {0.95}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.96±0.01 | 0.81±0.04 | \({\textbf {0.80}}\!\varvec{\pm }\!{\textbf {0.03}}\) | ||
NB | 2 | 0.89±0.03 | 0.92±0.01 | \({\textbf {0.85}}\!\varvec{\pm }\!{\textbf {0.06}}\) | 0.94±0.01 | \({\textbf {0.97}}\!\varvec{\pm }\!{\textbf {0.01}}\) | \({\textbf {0.81}}\!\varvec{\pm }\!{\textbf {0.03}}\) | 0.79±0.03 | ||
SVM | 1 | 0.86±0.03 | 0.88±0.02 | 0.84±0.06 | 0.88±0.02 | 0.96±0.02 | 0.71±0.05 | 0.68±0.04 | ||
ANN01 | 4 | 0.85±0.01 | 0.88±0.02 | 0.82±0.05 | 0.89±0.02 | 0.95±0.01 | 0.79±0.04 | 0.75±0.03 | ||
ANN02 | 2 | \({\textbf {0.90}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.92±0.03 | 0.83±0.07 | 0.87±0.03 | 0.94±0.03 | 0.77±0.05 | 0.74±0.03 | ||
LNEC | KNN | 2 | \({\textbf {0.93}}\!\varvec{\pm }\!{\textbf {0.02}}\) | \({\textbf {0.94}}\!\varvec{\pm }\!{\textbf {0.01}}\) | \({\textbf {0.91}}\!\varvec{\pm }\!{\textbf {0.05}}\) | 0.94±0.02 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.84±0.03 | 0.80±0.03 | |
LDA | 3 | 0.92±0.03 | 0.93±0.01 | 0.89±0.05 | 0.94±0.01 | 0.97±0.01 | 0.83±0.04 | 0.81±0.04 | ||
NB | 1 | 0.90±0.03 | 0.94±0.02 | 0.84±0.06 | \({\textbf {0.97}}\!\varvec{\pm }\!{\textbf {0.02*}}\) | 0.96±0.01 | 0.84±0.05 | 0.81±0.02 | ||
SVM | 2 | 0.92±0.03 | 0.94±0.02 | 0.90±0.05 | 0.95±0.02 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.01}}\) | 0.85±0.04 | \({\textbf {0.83}}\!\varvec{\pm }\!{\textbf {0.03}}\) | ||
ANN01 | 2 | 0.83±0.03 | 0.88±0.02 | 0.90±0.05 | 0.95±0.03 | 0.97±0.01 | \({\textbf {0.86}}\!\varvec{\pm }\!{\textbf {0.04}}\) | 0.82±0.02 | ||
ANN02 | 3 | 0.91±0.02 | 0.92±0.02 | 0.89±0.05 | 0.93±0.02 | 0.96±0.01 | 0.82±0.04 | 0.79±0.03 | ||
GSE10810 | GFS | KNN | 1 | 0.95±0.05 | 0.96±0.04 | 0.98±0.04 | 0.92±0.10 | 0.97±0.07 | 0.97±0.03 | \({\textbf {0.96}}\!\varvec{\pm }\!{\textbf {0.02*}}\) |
LDA | 1 | 0.95±0.06 | \({\textbf {0.97}}\!\varvec{\pm }\!{\textbf {0.04}}\) | \({\textbf {1.00}}\!\varvec{\pm }\!{\textbf {0.00}}\) | 0.90±0.12 | \({\textbf {1.00}}\!\varvec{\pm }\!{\textbf {0.00}}\) | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.03}}\) | 0.94±0.02 | ||
NB | 1 | 0.94±0.05 | 0.95±0.04 | 0.97±0.05 | 0.92±0.10 | 0.95±0.08 | 0.96±0.03 | 0.93±0.03 | ||
SVM | 2 | \({\textbf {0.96}}\!\varvec{\pm }\!{\textbf {0.05}}\) | \({\textbf {0.97}}\!\varvec{\pm }\!{\textbf {0.04}}\) | 0.99±0.03 | 0.92±0.10 | 0.99±0.04 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.03}}\) | 0.94±0.02 | ||
ANN01 | 3 | 0.93±0.04 | 0.94±0.04 | 0.96±0.03 | \({\textbf {0.92}}\!\varvec{\pm }\!{\textbf {0.08}}\) | 0.96±0.04 | 0.97±0.03 | 0.94±0.02 | ||
ANN02 | 3 | 0.95±0.06 | 0.93±0.05 | 0.95±0.03 | 0.90±0.13 | 0.95±0.05 | 0.94±0.04 | 0.92±0.03 | ||
PWFP | KNN | 3 | 0.70±0.11 | 0.65±0.12 | 0.52±0.16 | \({\textbf {0.88}}\!\varvec{\pm }\!{\textbf {0.14*}}\) | 0.51±0.10 | 0.64±0.15 | 0.60±0.10 | |
LDA | 1 | 0.62±0.12 | 0.61±0.11 | 0.59±0.16 | 0.66±0.22 | 0.47±0.13 | 0.65±0.12 | 0.58±0.09 | ||
NB | 2 | \({\textbf {0.76}}\!\varvec{\pm }\!{\textbf {0.12*}}\) | \({\textbf {0.75}}\!\varvec{\pm }\!{\textbf {0.11*}}\) | \({\textbf {0.71}}\!\varvec{\pm }\!{\textbf {0.14*}}\) | 0.81±0.18 | \({\textbf {0.62}}\!\varvec{\pm }\!{\textbf {0.15*}}\) | \({\textbf {0.78}}\!\varvec{\pm }\!{\textbf {0.11*}}\) | \({\textbf {0.72}}\!\varvec{\pm }\!{\textbf {0.06*}}\) | ||
SVM | 3 | 0.61±0.10 | 0.56±0.11 | 0.43±0.17 | 0.79±0.18 | 0.44±0.09 | 0.54±0.14 | 0.56±0.12 | ||
ANN01 | 3 | 0.65±0.06 | 0.67±0.04 | 0.57±0.03 | 0.77±0.08 | 0.58±0.09 | 0.66±0.13 | 0.61±0.10 | ||
ANN02 | 3 | 0.66±0.05 | 0.64±0.05 | 0.51±0.08 | 0.74±0.12 | 0.56±0.11 | 0.62±0.12 | 0.60±0.11 | ||
LNEC | KNN | 3 | 0.62±0.13 | 0.61±0.12 | 0.59±0.12 | 0.65±0.21 | 0.47±0.12 | 0.66±0.11 | 0.63±0.10 | |
LDA | 5 | \({\textbf {0.76}}\!\varvec{\pm }\!{\textbf {0.10*}}\) | \({\textbf {0.74}}\!\varvec{\pm }\!{\textbf {0.11*}}\) | \({\textbf {0.69}}\!\varvec{\pm }\!{\textbf {0.15*}}\) | 0.84±0.14 | \({\textbf {0.62}}\!\varvec{\pm }\!{\textbf {0.12*}}\) | \({\textbf {0.77}}\!\varvec{\pm }\!{\textbf {0.11*}}\) | \({\textbf {0.73}}\!\varvec{\pm }\!{\textbf {0.11*}}\) | ||
NB | 4 | 0.69±0.12 | 0.64±0.13 | 0.51±0.20 | \({\textbf {0.87}}\!\varvec{\pm }\!{\textbf {0.16}}\) | 0.52±0.14 | 0.62±0.18 | 0.61±0.13 | ||
SVM | 3 | 0.62±0.09 | 0.56±0.10 | 0.42±0.17 | 0.82±0.17 | 0.45±0.08 | 0.53±0.13 | 0.54±0.10 | ||
ANN01 | 3 | 0.68±0.06 | 0.63±0.09 | 0.49±0.11 | 0.79±0.11 | 0.56±0.07 | 0.58±0.11 | 0.57±0.09 | ||
ANN02 | 4 | 0.63±0.03 | 0.64±0.11 | 0.50±0.13 | 0.84±0.12 | 0.51±0.10 | 0.56±0.10 | 0.55±0.11 | ||
GSE15852 | GFS | KNN | 2 | 0.84±0.08 | 0.84±0.08 | 0.89±0.08 | 0.79±0.14 | 0.89±0.08 | 0.85±0.07 | 0.83±0.05 |
LDA | 3 | 0.83±0.08 | 0.83±0.08 | \({\textbf {0.98}}\!\varvec{\pm }\!{\textbf {0.05}}\) | 0.68±0.16 | \({\textbf {0.97}}\!\varvec{\pm }\!{\textbf {0.02}}\) | 0.85±0.06 | 0.82±0.05 | ||
NB | 4 | \({\textbf {0.89}}\!\varvec{\pm }\!{\textbf {0.07*}}\) | \({\textbf {0.89}}\!\varvec{\pm }\!{\textbf {0.07*}}\) | 0.96±0.07 | \({\textbf {0.81}}\!\varvec{\pm }\!{\textbf {0.13}}\) | 0.96±0.07 | \({\textbf {0.90}}\!\varvec{\pm }\!{\textbf {0.06}}\) | \({\textbf {0.88}}\!\varvec{\pm }\!{\textbf {0.06*}}\) | ||
SVM | 4 | 0.87±0.07 | 0.87±0.07 | 0.96±0.06 | 0.77±0.13 | 0.96±0.06 | 0.88±0.06 | 0.85±0.05 | ||
ANN01 | 5 | 0.83±0.04 | 0.85±0.06 | 0.90±0.08 | 0.79±0.09 | 0.92±0.07 | 0.84±0.09 | 0.80±0.10 | ||
ANN02 | 3 | 0.85±0.02 | 0.86±0.05 | 0.93±0.05 | 0.75±0.11 | 0.94±0.05 | 0.85±0.06 | 0.82±0.07 | ||
PWFP | KNN | 1 | 0.54±0.10 | 0.54±0.10 | 0.56±0.14 | 0.52±0.16 | 0.54±0.11 | 0.54±0.11 | 0.56±0.10 | |
LDA | 1 | 0.59±0.11 | 0.59 ±0.11 | 0.65±0.15 | 0.54±0.16 | 0.61±0.12 | 0.61±0.11 | 0.58±0.11 | ||
NB | 3 | 0.57±0.11 | 0.57±0.11 | 0.70±0.17 | 0.44±0.15 | 0.62±0.18 | 0.61±0.12 | 0.59±0.10 | ||
SVM | 1 | 0.57±0.09 | 0.57±0.09 | 0.67±0.14 | 0.48±0.15 | 0.59±0.11 | 0.61±0.10 | 0.60±0.11 | ||
ANN01 | 3 | \({\textbf {0.68}}\!\varvec{\pm }\!{\textbf {0.06*}}\) | \({\textbf {0.71}}\!\varvec{\pm }\!{\textbf {0.09*}}\) | \({\textbf {0.76}}\!\varvec{\pm }\!{\textbf {0.09*}}\) | \({\textbf {0.78}}\!\varvec{\pm }\!{\textbf {0.10*}}\) | \({\textbf {0.68}}\!\varvec{\pm }\!{\textbf {0.09*}}\) | 0.61±0.09 | 0.60±0.10 | ||
ANN02 | 4 | 0.65±0.05 | 0.68±0.08 | 0.72±0.06 | 0.70±0.13 | 0.63±0.08 | \({\textbf {0.65}}\!\varvec{\pm }\!{\textbf {0.09*}}\) | \({\textbf {0.63}}\!\varvec{\pm }\!{\textbf {0.10*}}\) | ||
LNEC | KNN | 2 | 0.57±0.11 | 0.57±0.11 | 0.66±0.14 | 0.48±0.15 | 0.59±0.13 | 0.60±0.10 | 0.58±0.11 | |
LDA | 4 | \({\textbf {0.61}}\!\varvec{\pm }\!{\textbf {0.12}}\) | \({\textbf {0.61}}\!\varvec{\pm }\!{\textbf {0.12*}}\) | 0.66±0.14 | \({\textbf {0.56}}\!\varvec{\pm }\!{\textbf {0.18}}\) | \({\textbf {0.63}}\!\varvec{\pm }\!{\textbf {0.15}}\) | 0.63±0.11 | \({\textbf {0.61}}\!\varvec{\pm }\!{\textbf {0.10}}\) | ||
NB | 2 | 0.57±0.10 | 0.57±0.10 | \({\textbf {0.73}}\!\varvec{\pm }\!{\textbf {0.15}}\) | 0.41±0.16 | 0.61±0.16 | \({\textbf {0.63}}\!\varvec{\pm }\!{\textbf {0.09}}\) | 0.59±0.10 | ||
SVM | 4 | 0.53±0.11 | 0.53±0.11 | 0.50±0.18 | \({\textbf {0.56}}\!\varvec{\pm }\!{\textbf {0.18}}\) | 0.53±0.11 | 0.50±0.14 | 0.48±0.12 | ||
ANN01 | 2 | 0.60±0.01 | 0.58±0.11 | 0.70±0.08 | 0.52±0.10 | 0.55±0.10 | 0.61±0.13 | 0.58±0.11 | ||
ANN02 | 3 | 0.57±0.09 | 0.59±0.07 | 0.65±0.16 | 0.52±0.14 | 0.60±0.09 | 0.59±0.11 | 0.53±0.10 |