Table 4 Examples of drug-drug similarity based on shared side effect elements found by the Jaccard similarity method
From: Analysis and identification of drug similarity through drug side effects and indications data
Drug pairs | Shared side effect elements | Similarity | P-value |
|---|---|---|---|
Gamma-aminobutyric- acid HBIG | Anaphylactic shock, Angioedema, Urticaria, Injection site tenderness, Injection site pain and Pain | 1.0 | 0.012 |
Estrone Estradiol-cyclopentylpropionate | Abdominal cramps, Depression, Dizziness, Anaphylactic shock, Rash, Dermatitis, Headache, Cramps of lower extremities, Muscle spasms, Nausea, Pruritus, Musculoskeletal discomfort, Anaphylactic shock, Urticaria, etc | 0.9733 | 0.019 |
Flumethasone Alclometasone | Secondary infection, Dermatitis, Pruritus, Leukoderma, Folliculitis, Allergic contact dermatitis, Skin atrophy, Acneiform eruption, and Dermatitis perioral | 0.8235 | 0.025 |
Alclometasone Clocortolon | Rash, Dermatitis, Leukoderma, Folliculitis, Allergic contact dermatitis, Skin striae, Pruritus, and Eruption | 0.7222 | 0.041 |