Table 3 Examples of drug-drug similarity based on shared indication elements found by the Jaccard similarity method
From: Analysis and identification of drug similarity through drug side effects and indications data
Drug pairs | Shared indication elements | Similarity | P-value |
|---|---|---|---|
Fluoxymesterone Testosterone | Wounds and Injuries, Malignant neoplasm of the breast, Hypogonadism, Neoplasms, Cryptorchidism, Orchitis, Puberty, Delayed Puberty, Testicular hypogonadism, Hypogonadotropic hypogonadism, Primary hypogonadism, and Testosterone deficiency | 0.9166 | 0.016 |
Benazepril Benazeprilat | Hypertensive disease, Kidney Diseases, Renal Insufficient, Angioedema, and Renal Artery Stenosis | 0.8544 | 0.021 |
Felodipine Aliskiren | Hypertensive disease, Myocardial Infarction, Angina Pectoris, Hyperlipidemia, Heart failure, Diabetic Nephropathy, and Diabetes Mellitus | 0.75 | 0.028 |
Cortisol Methylprednisolone | Malignant Neoplasms, Edema, Pneumonia, Wounds and Injuries, Dermatologic disorders, Allergic conditions, Arthritis, Rheumatoid Arthritis, Dermatitis, Inflammation, Degenerative polyarthritis, Asthma, Diuresis, Hematological Disease, Tuberculosis, Hay fever, and so on | 0.6950 | 0.032 |