Fig. 3

The process for combining analyses results from SAIL (Wales) and NHS Digital TRE for England. The SAIL Databank for Wales and the NHS Digital TRE for England provide a secure remote data access system and analysis environment. Many phenotype code-lists in the HDR UK Phenotype Library [12] have already been uploaded/imported in these TREs. Approved researchers within each TRE can access data and phenotype code-lists, and perform analyses in the TRE. Then the results of analyses from these TREs can be combined (using meta-analysis) outside of the TREs once approved through the TREs disclosure control process, with phenotype code-lists and code accessible outside the TREs, and a copy of what is needed imported/exported from the TREs as required through standard disclosure control processes