Table 1 Patient baseline characteristics
Covariate | 2013 | 2018 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDCD (N = 328,740) | DOD (N = 804,707) | MDCD (N = 491,311) | DOD (N = 1,109,389) | |||||||||
SNOMED CT | Quana | SMD | SNOMED CT | Quana | SMD | SNOMED CT | Quanb | SMD | SNOMED CT | Quanb | SMD | |
Age, years, mean (sd) | 53.51 (20.97) | – | 64.05 (19.29) | – | 46.85 (19.83) | – | 64.24 (18.14) | – | ||||
Sex, n (%) | ||||||||||||
Male | 93,772 (28.5) | – | 327,921 (40.8) | – | 154,671 (31.5) | – | 467,011 (42.1) | – | ||||
Female | 234,968 (71.5) | – | 476,786 (59.2) | – | 336,640 (68.5) | – | 642,378 (57.9) | – | ||||
Charlson comorbidity index, mean (sd) | 3.75 (3.66) | 3.6 (3.56) | 0.03 | 3.63 (3.62) | 3.51 (3.55) | 0.02 | 4.04 (4) | 3.91 (3.92) | 0.02 | 4.55 (3.93) | 4.43 (3.86) | 0.02 |
Comorbid Conditions, n (%) | ||||||||||||
Myocardial infraction | 42,067 (12.8) | 42,067 (12.8) | 0 | 111,478 (13.9) | 111,478 (13.9) | 0 | 72,069 (14.7) | 72,057 (14.7) | 0 | 192,333 (17.3) | 192,333 (17.3) | 0 |
Congestive heart failure | 83,481 (25.4) | 83,482 (25.4) | 0 | 173,183 (21.5) | 173,175 (21.5) | 0 | 129,372 (26.3) | 129,712 (26.4) | 0 | 320,600 (28.9) | 321,007 (28.9) | 0 |
Peripheral vascular disease | 73,630 (22.4) | 73,381 (22.3) | 0 | 212,834 (26.5) | 212,337 (26.4) | 0 | 123,268 (25.1) | 121,219 (24.7) | 0.01 | 383,111 (34.5) | 378,005 (34.1) | 0.01 |
Cerebrovascular disease | 83,041 (25.3) | 83,030 (25.3) | 0 | 227,055 (28.2) | 227,045(28.2) | 0 | 121,917 (24.8) | 121,824 (24.8) | 0 | 351,730 (31.7) | 351,659 (31.7) | 0.00 |
Dementia | 36,021 (11) | 26,351 (8) | 0.07 | 65,097 (8.1) | 46,465 (5.8) | 0.06 | 49,312 (10) | 47,300 (9.6) | 0.01 | 127,958 (11.5) | 125,035 (11.3) | 0.01 |
Chronic pulmonary disease | 167,349 (50.9) | 167,165(50.9) | 0 | 328,588 (40.8) | 328,129(40.8) | 0 | 261,239 (53.2) | 261,161 (53.2) | 0 | 491,536 (44.3) | 491,425 (44.3) | 0 |
Rheumatic disease | 22,664 (6.9) | 21,326 (6.5) | 0.01 | 64,375(8) | 59,095 (7.3) | 0.02 | 37,012 (7.5) | 32,366 (6.6) | 0.03 | 107,692 (9.7) | 92,573 (8.3) | 0.04 |
Peptic ulcer disease | 21,419 (6.5) | 21,419 (6.5) | 0 | 45,029 (5.6) | 45,029 (5.6) | 0 | 33,855 (6.9) | 33,855 (6.9) | 0 | 70,761 (6.4) | 70,761 (6.4) | 0 |
Mild liver disease | 49,682 (15.1) | 48,863 (14.9) | 0.01 | 116,317 (14.5) | 115,402 (14.3) | 0 | 103,234 (21) | 100,175 (20.4) | 0.01 | 198,534 (17.9) | 193,778 (17.5) | 0.01 |
Diabetes without chronic complications | 123,552 (37.6) | 123,547 (37.6) | 0 | 268,579 (33.4) | 268,552 (33.4) | 0 | 180,707 (36.8) | 178,911 (36.4) | 0.01 | 44,1097 (39.8) | 436,760 (39.4) | 0.01 |
Diabetes with chronic complications | 66,637 (20.3) | 54,233 (16.5) | 0.06 | 136,618 (17) | 117,527 (14.6) | 0.04 | 123,869 (25.2) | 111,701 (22.7) | 0.04 | 293,174 (26.4) | 267,237 (24.1) | 0.04 |
Hemiplegia or paraplegia | 23,748 (7.2) | 23,420 (7.1) | 0 | 30,802 (3.8) | 30,170 (3.8) | 0 | 41,778 (8.5) | 40,428 (8.2) | 0.01 | 60,555 (5.5) | 58,900 (5.3) | 0.01 |
Renal disease | 69,341 (21.1) | 65,131(19.8) | 0.02 | 170,506 (21.2) | 161,663 (20.1) | 0.02 | 106,497 (21.7) | 102,761 (20.9) | 0.01 | 330,026 (29.8) | 325,401 (29.3) | 0.01 |
Malignancy, except skin neoplasms | 40,114 (12.2) | 38,912 (11.8) | 0.01 | 161,419 (20.1) | 158,319 (19.7) | 0.01 | 60,499 (12.3) | 58,426 (11.9) | 0.01 | 247,915 (22.4) | 241,187 (21.7) | 0.01 |
Moderate or severe liver disease | 7,262 (2.2) | 7,262 (2.2) | 0 | 10,887 (1.4) | 10,881 (1.4) | 0 | 15,374 (3.1) | 13,194 (2.7) | 0.02 | 24,232 (2.2) | 19,882 (1.8) | 0.02 |
Metastatic solid tumor | 12,461 (3.8) | 12,248 (3.7) | 0 | 42,841 (5.3) | 42,151 (5.2) | 0 | 19,762 (4) | 18,820 (3.8) | 0.01 | 66,772 (6) | 64,521 (5.8) | 0.01 |
AIDS/HIV | 5,437 (1.7) | 5,437 (1.7) | 0 | 3,124 (0.4) | 3,124 (0.4) | 0 | 7,471 (1.5) | 7,471 (1.5) | 0 | 4,850 (0.4) | 4,850 (0.4) | 0 |