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Table 1 Descriptive summary statistics for all datasets

From: Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts

Dependent: Set Index

 

Train

Validation

Total

p value

Center

Dundee

0 (0.0)

295 (100.0)

295 (24.0)

 < 0.001

 

Imperial

180 (19.3)

0 (0.0)

180 (14.6)

 
 

Oxford

557 (59.6)

0 (0.0)

557 (45.3)

 
 

Technion

198 (21.2)

0 (0.0)

198 (16.1)

 

EQ5D_Index

Median (IQR)

0.7 (0.6 to 0.8)

0.7 (0.5 to 0.8)

0.7 (0.5 to 0.8)

0.015

Depression_tscore

Median (IQR)

49.4 (42.2 to 56.8)

52.0 (41.0 to 58.7)

49.4 (41.0 to 57.5)

0.001

Anxiety_tscore

Median (IQR)

45.9 (37.1 to 56.4)

51.4 (40.3 to 57.5)

48.5 (40.3 to 56.4)

0.001

Sleep_Disturbance_tscore

Median (IQR)

56.3 (50.1 to 59.4)

51.8 (49.6 to 54.4)

53.3 (49.7 to 57.8)

 < 0.001

Trauma

No

417 (44.6)

184 (62.4)

601 (48.9)

0.378

 

Yes

194 (20.7)

99 (33.6)

293 (23.8)

 
 

(Missing)

324 (34.7)

12 (4.1)

336 (27.3)

 

Hospital_stay

No

529 (56.6)

230 (78.0)

759 (61.7)

0.649

 

Yes

81 (8.7)

31 (10.5)

112 (9.1)

 
 

(Missing)

325 (34.8)

34 (11.5)

359 (29.2)

 

TIPIExtraversion

Median (IQR)

4.0 (3.0 to 5.0)

4.0 (3.0 to 5.0)

4.0 (3.0 to 5.0)

0.280

TIPIAgreeableness

Median (IQR)

5.0 (4.0 to 6.0)

5.0 (4.0 to 6.0)

5.0 (4.0 to 6.0)

0.531

TIPIConscientiousness

Median (IQR)

6.0 (4.5 to 6.5)

5.5 (4.5 to 6.5)

6.0 (4.5 to 6.5)

0.001

TIPIEmotionalStability

Median (IQR)

5.0 (4.0 to 6.5)

4.5 (4.0 to 6.0)

4.5 (4.0 to 6.5)

0.145

TIPIOpenness

Median (IQR)

5.0 (4.0 to 6.0)

4.5 (4.0 to 5.6)

4.5 (4.0 to 6.0)

0.069

Ever_smoked_status

No

312 (33.4)

116 (39.3)

428 (34.8)

0.001

 

Yes

296 (31.7)

177 (60.0)

473 (38.5)

 
 

(Missing)

327 (35.0)

2 (0.7)

329 (26.7)

 

Alcohol_consumption

Never

201 (21.5)

88 (29.8)

289 (23.5)

0.014

 

Less than 1 day per month

119 (12.7)

75 (25.4)

194 (15.8)

 
 

1 to 3 days per month

74 (7.9)

50 (16.9)

124 (10.1)

 
 

1 or 2 days per week

102 (10.9)

34 (11.5)

136 (11.1)

 
 

3 or 4 days per week

44 (4.7)

24 (8.1)

68 (5.5)

 
 

Daily or almost daily

68 (7.3)

21 (7.1)

89 (7.2)

 
 

(Missing)

327 (35.0)

3 (1.0)

330 (26.8)

 

Alcohol_consumption_likert

Median (IQR)

1.0 (0.0 to 3.0)

1.0 (0.0 to 3.0)

1.0 (0.0 to 3.0)

0.412

Alcohol_status

No

201 (21.5)

88 (29.8)

289 (23.5)

0.422

 

Yes

407 (43.5)

204 (69.2)

611 (49.7)

 
 

(Missing)

327 (35.0)

3 (1.0)

330 (26.8)

 

PCS_score

Median (IQR)

10.0 (3.0 to 23.0)

8.0 (4.0 to 20.0)

10.0 (3.0 to 22.0)

0.319

MNSI_score

Median (IQR)

5.0 (3.0 to 7.0)

4.0 (3.0 to 6.0)

5.0 (3.0 to 6.0)

0.146

DN4_score

Median (IQR)

4.0 (3.0 to 6.0)

3.0 (2.0 to 5.0)

4.0 (3.0 to 6.0)

 < 0.001

Age

Median (IQR)

68.0 (60.0 to 74.0)

69.0 (63.0 to 77.0)

68.0 (61.0 to 74.0)

0.006

Gender

Female

300 (32.1)

104 (35.3)

404 (32.8)

0.335

 

Male

634 (67.8)

190 (64.4)

824 (67.0)

 
 

(Missing)

1 (0.1)

1 (0.3)

2 (0.2)

 

BMI

Median (IQR)

29.0 (26.0 to 32.9)

31.2 (27.8 to 35.5)

29.4 (26.2 to 33.5)

 < 0.001

HBA1C

Median (IQR)

7.4 (6.6 to 8.5)

7.4 (6.7 to 8.7)

7.4 (6.7 to 8.5)

0.165

Diabetes_Duration

Median (IQR)

13.5 (8.0 to 20.0)

15.0 (12.0 to 20.0)

15.0 (11.0 to 20.0)

0.005

Cholesterol

Median (IQR)

4.1 (3.5 to 4.6)

3.9 (3.4 to 4.4)

3.9 (3.4 to 4.5)

0.141

LDL

Median (IQR)

2.1 (1.8 to 2.8)

2.0 (1.5 to 2.5)

2.0 (1.6 to 2.5)

0.159

HDL

Median (IQR)

1.2 (1.0 to 1.4)

1.1 (0.9 to 1.3)

1.1 (0.9 to 1.3)

0.018

Creatinine

Median (IQR)

75.0 (66.0 to 86.5)

80.0 (64.0 to 99.0)

79.5 (65.0 to 96.0)

0.124

TRIGLYCERIDES

Median (IQR)

1.7 (1.2 to 2.0)

1.8 (1.3 to 2.6)

1.7 (1.3 to 2.5)

0.041

CKD

No

926 (99.0)

272 (92.2)

1198 (97.4)

 < 0.001

 

Yes

9 (1.0)

23 (7.8)

32 (2.6)

 

Outcome

Painful_neuropathy

617 (66.0)

181 (61.4)

798 (64.9)

0.166

 

Painless_neuropathy

318 (34.0)

114 (38.6)

432 (35.1)

 
  1. Set index indicates the training or validation dataset. Numerical variables are represented by the median and Inter Quantile Range (IQR) in brackets, categorical variables by the absolute occurrence and percentage in brackets. Columns hold from left to right data for the Training, Validation and both datasets together. Right most column holds the p.value of the comparison between Training and Validation datasets using the chi-square test for categorical variables or the Kruskal Walis test for numerical variables. The number and rate of missing values is indicated for all factor levels
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