Identifying drug-related attributes to personalise antihypertensive agents: the outcome report of patients receiving metoprolol therapy

Table 1 Normalisation of clinical references of the 19 targeted attributes

Attribute	Attribute max	Attribute min	Reference range	Normalised reference
HCT	0.54	0.13	0.35–0.45	0.537–0.780
HB	185	44	110–150	0.468–0.752
PLT	494	2	100–300	0.200–0.606
Cr	1161	4	44–132	0.035–0.111
Urea	34	0.86	3.1–7.1	0.070–0.188
UA	743	13.4	150–420	0.187–0.557
Cys	8.58	0.08	0.59–1.03	0.060–0.112
TC	9.62	0.21	3.1–5.7	0.307–0.583
LDL	6.54	0.01	1.5–3.36	0.228–0.513
HDL	2.85	0.08	0.8–1.6	0.260–0.549
K⁺	6.17	2.42	3.5–5.5	0.288–0.821
Na⁺	172.2	124	135–145	0.228–0.436
FPG	22.9	0.76	3.9–6.1	0.142–0.241
Age	104	7
Sex	2 (Female)	1 (Male)	1,2	[0,1]
SBP	263	67	90–140	0.117–0.372
DBP	168	18	60–60	0.280–0.480
PP	128.5	10	20–60	0.084–0.422
HR	172	20	60–100	0.263–0.526

HCT: haematocrit (L/L), HB: haemoglobin (g/L), Cr: serum creatinine (μmol/L), Cys: serum cystatin C (mg/L), Urea: serum urea (mmol/L), UA: serum uric acid (μmol/L), TC: cholesterol (mmol/L), LDL: low-density lipoprotein cholesterol (mmol/L), HDL: high-density lipoprotein cholesterol (mmol/L); K⁺: potassium (mmol/L); Na⁺: sodium (mmol/L); FPG: fasting blood glucose (mmol/L); PLT: platelet count (109/L); Age (years); Sex (male/female); SB: systolic pressure (mmHg); DB: diastolic pressure (mmHg); PP: pulse pressure (mmHg); HR: heart rate (per min)

ISSN: 1472-6947