Adapted time-varying covariates Cox model for predicting future cirrhosis development performs well in a large hepatitis C cohort

Table 3 Misclassification table

Follow-up interval, laboratory window (years)	Test sample (n)*	Event proportion	AUROC	Brier score	Best cut-off	Specificity	Sensitivity	PPV	NPV
1, 2	34,081	0.030	0.815	0.028	0.057	0.737	0.749	0.080	0.990
3, 2	30,117	0.161	0.811	0.133	0.059	0.767	0.719	0.373	0.934
5, 2	28,604	0.329	0.794	0.274	0.056	0.750	0.703	0.579	0.838
1, 4	25,934	0.026	0.796	0.031	0.105	0.731	0.712	0.066	0.990
3, 4	20,765	0.083	0.781	0.069	0.104	0.732	0.703	0.191	0.965
5, 4	18,164	0.230	0.792	0.172	0.105	0.723	0.721	0.438	0.897

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