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Table 2 Characteristics of each analysis and signals for drug

From: An OMOP-CDM based pharmacovigilance data-processing pipeline (PDP) providing active surveillance for ADR signal detection from real-world data sources

Study KYUH-EHR FAERS
Area (year of enrollment) Korea (2014–2018) U.S.A (2012–2018)
Adjustment Sex, age, hospitalization period, number of outpatient visits
Drug Hazard ratio (95% CI) Odds ratio (95% CI)
 Acetaminophen 1.59 (1.47–1.72)* 0.80 (0.77–0.84)
 Cimetidine 0.74 (0.61–0.91) 0.98 (0.69–1.36)
 Digoxin 1.60 (1.08–2.38)* 0.73 (0.66–0.80)
 Doxycycline 1.73 (1.14–2.62)* 1.30 (1.20–1.40)*
 Epinephrine 1.03 (0.91–1.18) 0.62 (0.53–0.72)
 Hydroxyzine 0.98 (0.72–1.34) 1.17 (1.06–1.29)*
 Metoclopramide 3.35 (3.01–3.74)* 0.80 (0.72–0.90)
 Nortriptyline 8.06 (2.41–26.91)* 1.94 (1.73–2.16)*
 Sucralfate 1.21 (1.06–1.38)* 1.22 (1.01–1.45)*
  1. *P<0.05