Table 2 Characteristics of each analysis and signals for drug

Area (year of enrollment)

Korea (2014–2018)

U.S.A (2012–2018)

Adjustment

Sex, age, hospitalization period, number of outpatient visits

–

Drug

Hazard ratio (95% CI)

Odds ratio (95% CI)

 Acetaminophen

1.59 (1.47–1.72)*

0.80 (0.77–0.84)

 Cimetidine

0.74 (0.61–0.91)

0.98 (0.69–1.36)

 Digoxin

1.60 (1.08–2.38)*

0.73 (0.66–0.80)

 Doxycycline

1.73 (1.14–2.62)*

1.30 (1.20–1.40)*

 Epinephrine

1.03 (0.91–1.18)

0.62 (0.53–0.72)

 Hydroxyzine

0.98 (0.72–1.34)

1.17 (1.06–1.29)*

 Metoclopramide

3.35 (3.01–3.74)*

0.80 (0.72–0.90)

 Nortriptyline

8.06 (2.41–26.91)*

1.94 (1.73–2.16)*

 Sucralfate

1.21 (1.06–1.38)*

1.22 (1.01–1.45)*