Table 3 Statistical description of the two phenotypes of the training set
From: Selection strategy for sedation depth in critically ill patients on mechanical ventilation
Features (mean ± SD) | Profile1 (n = 3500) | Profile2 (n = 1247) | P value |
|---|---|---|---|
Age | 64.57 ± 16.19 | 61.77 ± 16.70 | < 0.001 |
SAPS II | 37.92 ± 13.47 | 46.63 ± 17.22 | < 0.001 |
SOFA scores | 4.88 ± 3.00 | 7.20 ± 4.28 | < 0.001 |
White blood cell (WBC) | 11.78 ± 4.64 | 14.59 ± 15.52 | < 0.001 |
Hemoglobin (Hb) | 10.65 ± 1.81 | 10.75 ± 2.13 | 0.122 |
Hematocrit | 31.77 ± 5.18 | 32.28 ± 6.33 | 0.005 |
Platelet | 207.19 ± 101.90 | 220.82 ± 129.40 | < 0.001 |
Urea Nitrogen (BUN) | 22.49 ± 15.99 | 33.20 ± 27.95 | < 0.001 |
pH | 7.38 ± 0.06 | 7.34 ± 0.09 | < 0.001 |
pO2 | 203.65 ± 85.69 | 148.41 ± 72.72 | < 0.001 |
pCO2 | 41.49 ± 7.34 | 43.08 ± 11.52 | < 0.001 |
Bicarbonate (HCO3−) | 23.95 ± 3.64 | 22.67 ± 5.41 | < 0.001 |
Lactate (Lac) | 2.01 ± 0.93 | 2.85 ± 2.25 | < 0.001 |
Potassium (K) | 4.21 ± 0.51 | 4.26 ± 0.62 | 0.003 |
Sodium (Na) | 138.13 ± 3.65 | 138.28 ± 4.96 | 0.245 |
Chlorine (Cl) | 105.49 ± 4.88 | 104.88 ± 6.29 | 0.001 |
Total calcium (TotalCa) | 8.27 ± 0.63 | 8.18 ± 0.99 | < 0.001 |
Partial thromboplastin time (PTT) | 34.06 ± 12.31 | 40.74 ± 20.78 | < 0.001 |
Fluid balance | 4023.84 ± 3505.98 | 6143.63 ± 17,240.77 | < 0.001 |
Positive expiratory end pressure (PEEP) | 5.56 ± 1.24 | 7.20 ± 3.01 | < 0.001 |
Oxygen concentration in the inhalation gas (FiO2) | 54.52 ± 11.58 | 60.39 ± 16.45 | < 0.001 |
Tidal volume (VT) | 504.45 ± 91.65 | 563.87 ± 307.72 | < 0.001 |
Peak airway pressure (Ppeak) | 19.21 ± 4.72 | 23.29 ± 6.73 | < 0.001 |
Mean airway pressure (Pmean) | 8.76 ± 1.88 | 11.40 ± 3.99 | < 0.001 |
Platform pressure (Pplat) | 17.53 ± 3.43 | 20.44 ± 5.22 | < 0.001 |
Heart rate (HR) | 84.46 ± 13.91 | 90.54 ± 18.27 | < 0.001 |
Mean arterial pressure (MAP) | 78.46 | 78.05 ± 17.84 | 0.288 |
Respiratory rate (RR) | 18.04 ± 3.13 | 20.79 ± 4.40 |  < 0.001 |
Temperature | 36.84 ± 0.58 | 36.79 ± 0.92 | 0.037 |
Pulse oxygen saturation (SpO2%) | 97.84 ± 1.54 | 96.72 ± 3.43 | < 0.001 |
Richmond-ASS scores | − 1.39 ± 1.34 | − 2.15 ± 1.74 | < 0.001 |
Dexmedetomidine | 0.01 ± 0.05 | 0.42 ± 1.47 | < 0.001 |
Fentanyl | 0.57 ± 1.26 | 11.82 ± 19.99 | < 0.001 |
Midazolam | 8.29 ± 23.13 | 225.89 ± 546.80 | < 0.001 |
Morphine | 7.27 ± 12.10 | 37.56 ± 161.65 | < 0.001 |
Propofol | 2219.76 ± 3271.76 | 8727.05 ± 14,805.89 | < 0.001 |