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Table 2 Top 10 OR results for 4-drug combination vs. 1-drug: with Bonferroni correction, a significant p is 3.75E-7

From: Mining and visualizing high-order directional drug interaction effects using the FAERS database

4-drug combination1-drug combinationORp-value
Fentanyl, Gabapentin, Levofloxacin, ZoledronateFentanyl43.306.52E-181
Fentanyl, Levofloxacin, Omeprazole, ZoledronateFentanyl38.792.03E-168
Ciprofloxacin, Fentanyl, Levofloxacin, ZoledronateFentanyl36.701.15E-157
Acetaminophen, Doxorubicin, Omeprazole, ZoledronateDoxorubicin35.404.44E-114
Capecitabine, Dexamethasone, Fentanyl, ZoledronateCapecitabine34.369.61E-100
Alprazolam, Fentanyl, Levofloxacin, ZoledronateFentanyl34.331.19E-146
Acetaminophen, Doxorubicin, Levofloxacin, ZoledronateDoxorubicin33.534.23E-113
Ciprofloxacin, Fentanyl, Levofloxacin, OxycodoneFentanyl33.402.10E-146
Fentanyl, Gabapentin, Metoclopramide, ZoledronateMetoclopramide33.134.86E-117
Docetaxel, Oxycodone, Prochlorperazine, ZoledronateDocetaxel32.971.57E-140