Skip to main content

Table 4 Associations of 4-hydroxy-2-nonenal (HNE)-protein adducts and autoantibody isotypes against unmodified and HNE-modified peptides in rheumatoid arthritis (RA) patients vs. healthy controls (HCs)

From: Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

Risk factor   Cutoff HC RA Age-adjusted logistic regression modela p value Power
(n) (n) OR (95% CI)
HNE-protein adduct < 2.386 26 24 1.0 (Ref) 0.014 0.743
2.386 34 71 2.413 (1.193, 4.880)   
IgG anti-CFAH1121−1230 < 0.175 14 8 1.0 (Ref) 0.013 0.874
0.175 46 87 3.293 (1.286, 8.431)   
IgG anti-CFAH1121−1230 HNE < 0.263 46 51 1.0 (Ref) 0.005 0.870
0.263 14 44 2.808 (1.363, 5.785)   
IgM anti-CFAH1121−1230 < 0.609 35 20 1.0 (Ref) < 0.001 0.979
0.609 25 75 5.204 (2.550, 10.617)   
IgM anti-CFAH1121−1230 HNE < 0.333 39 39 1.0 (Ref) 0.004 0.838
0.333 21 56 2.700 (1.378, 5.289)   
IgG anti-HPT78−108 < 0.662 35 37 1.0 (Ref) 0.024 0.645
0.662 25 58 2.156 (1.108, 4.193)   
IgG anti-HPT78−108 HNE < 0.307 41 51 1.0 (Ref) 0.094 0.455
0.307 19 44 1.821 (0.904, 3.672)   
IgM anti-HPT78−108 < 0.326 40 42 1.0 (Ref) 0.005 0.841
0.326 20 53 2.695 (1.356, 5.354)   
IgM anti-HPT78−108 HNE < 0.187 39 25 1.0 (Ref) < 0.001 0.985
0.187 21 70 5.235 (2.594, 10.565)   
IgG anti-IGKC2−19 < 0.392 35 22 1.0 (Ref) < 0.001 0.974
0.392 25 73 4.679 (2.317, 9.449)   
IgG anti-IGKC2−19 HNE < 0.427 33 26 1.0 (Ref) < 0.001 0.905
0.427 27 69 3.206 (1.621, 6.340)   
IgM anti-IGKC2−19 < 0.743 56 50 1.0 (Ref) < 0.001 > 0.999
0.743 4 45 12.655 (4.244, 37.734)   
IgM anti-IGKC2−19 HNE < 0.738 53 47 1.0 (Ref) < 0.001 > 0.999
0.738 7 48 8.095 (3.312, 19.780)   
IgG anti-THRB328−345 < 0.154 19 7 1.0 (Ref) < 0.001 0.951
0.154 41 88 5.761 (2.228, 14.895)   
IgG anti-THRB328−345 HNE < 0.281 26 7 1.0 (Ref) < 0.001 0.962
0.281 34 88 9.524 (3.777, 24.012)   
IgM anti-THRB328−345 < 0.791 46 56 1.0 (Ref) 0.029 0.697
0.791 14 39 2.249 (1.086, 4.659)   
IgM anti-THRB328−345 HNE < 0.682 48 42 1.0 (Ref) < 0.001 0.992
0.682 12 53 5.043 (2.377, 10.696)   
  1. aOR, odds ratio; Ref, reference value
\