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Table 4 Manually selected 51 activated GO terms using human tissue samples

From: Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2

go_id

go_term_name

p.value

   

GO:0016032

Viral process

7.75E−08

GO:0002221

Pattern recognition receptor signaling pathway

6.55E−15

GO:0034340

Response to type I interferon

1.78E−15

GO:0034341

Response to interferon-gamma

8.43E−25

GO:0042742

Defense response to bacterium

4.74E −13

GO:0035455

Response to interferon-alpha

8.74E −07

GO:0045071

Negative regulation of viral genome replication

2.38E −14

GO:0035456

Response to interferon-beta

9.80E−06

GO:0051607

Defense response to virus

1.54E−24

GO:0046597

Negative regulation of viral entry into host cell

0.00040034

GO:0060337

Type I interferon signaling pathway

6.45E−16

GO:0039530

MDA-5 signaling pathway

0.00446572

GO:0009615

Response to virus

1.60E−28

GO:0060326

Cell chemotaxis

4.46E−19

GO:0045088

Regulation of innate immune response

1.92E−18

GO:0048247

Lymphocyte chemotaxis

1.49E−11

GO:0098586

Cellular response to virus

0.00074571

GO:0006959

Humoral immune response

2.95E−16

GO:0071347

Cellular response to interleukin-1

7.13E−07

GO:0006935

Chemotaxis

1.01E−10

GO:0071356

Cellular response to tumor necrosis factor

4.84E−07

GO:0019731

Antibacterial humoral response

0.00133157

GO:1990869

Cellular response to chemokine

3.29E−08

GO:0002237

Response to molecule of bacterial origin

4.05E−16

GO:0043123

Positive regulation of I-kappaB kinase/NF-kappaB signaling

1.01E−06

GO:0001817

Regulation of cytokine production

3.41E−25

GO:0009617

Response to bacterium

2.67E−25

GO:0051591

Response to cAMP

0.00254496

GO:0071346

Cellular response to interferon-gamma

4.49E−22

GO:0019079

Viral genome replication

4.70E−10

GO:0045089

Positive regulation of innate immune response

1.27E−15

GO:0031663

Lipopolysaccharid E-mediated signaling pathway

1.10E−08

GO:0002224

Toll-like receptor signaling pathway

1.09E−07

GO:0048245

Eosinophil chemotaxis

4.79E−05

GO:0050832

Defense response to fungus

0.00026658

GO:0070098

Chemokin E-mediated signaling pathway

4.75E−08

GO:0002548

Monocyte chemotaxis

6.18E−09

GO:0045055

Regulated exocytosis

1.68E−24

GO:0002218

Activation of innate immune response

9.08E−15

GO:0007249

I-kappaB kinase/NF-kappaB signaling

7.22E−08

GO:0034612

Response to tumor necrosis factor

2.65E−07

GO:0043122

Regulation of I-kappaB kinase/NF-kappaB signaling

1.61E−07

GO:0070555

Response to interleukin-1

5.34E−07

GO:0039528

cytoplasmic pattern Recognition receptor signaling pathway in response to virus

0.01386028

GO:0002430

Complement receptor mediated signaling pathway

2.11E−05

GO:0050920

Regulation of chemotaxis

1.71E−08

GO:0050688

Regulation of defense response to virus

3.49E−06

GO:0030595

Leukocyte chemotaxis

3.11E−20

GO:0071357

Cellular response to type I interferon

6.45E−16

GO:0019058

Viral life cycle

1.15E−09

GO:0001819

Positive regulation of cytokine production

5.35E−15

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