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Table 4 LCSD algorithm based on PPRA optimization

From: Identification of hot regions in hub protein–protein interactions by clustering and PPRA optimization

Input: Datasets

Output: Optimized Hot Region \(LCSD\_Best\_CH_i\)

Step 1: Feature selection for residues in datasets;

Step 2: A clustering-based boundary point recognition algorithm is used to obtain the predicted set of hot regions LCSD_RH1;

Step 3: \(LCSD\_RH1\) is optimized by PPRA to obtain hot region \(LCSD\_RH2\);

Step 4: \(LCSD\_RH2\) is optimized according to the loss residue optimization strategy;

Step 5: Repeat step 4 until there is no missing residue need to be processed;

Step 6: Input the optimized hot regions \(LCSD\_Best\_CH_i\).