Table 4 The discriminative ability of PSA, PCPT, PBCG, ERSPC and IPRC using the areas under the curve (AUC) and 95% confidence interval of the calculated probabilities. The p-values indicate if the difference between each method and IPRC is significant
From: A risk calculator to inform the need for a prostate biopsy: a rapid access clinic cohort
Models | Prostate cancer (n = 4801) | High grade cancer (n = 2548) | ||||
|---|---|---|---|---|---|---|
AUC | 95% CI | p-value | AUC | 95% CI | p-value | |
PSA | 0.5948 | 0.5789–0.6107 | P < 0.001 | 0.6623 | 0.6413–0.6832 | P < 0.001 |
PCPT | 0.6304 | 0.6148–0.6460 | P < 0.001 | 0.6804 | 0.6597–0.7012 | 0. 005 |
PBCG | 0.6528 | 0.6375–0.6681 | P < 0.001 | 0.7185 | 0.6988–0.7381 | 0.839 |
ERSPC | 0.6502 | 0.6349–0.6655 | P < 0.001 | 0.7140 | 0.6942–0.7338 | 0.604 |
IPRC | 0.6741 | 0.6591–0.6890 | – | 0.7214 | 0.7018–0.7409 | – |