Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats

Table 1 Top DE-miRNAs from Case vs. control (18 DE-miRs total) and Treatment vs. case (8 DE-miRs total)

Case vs. control				Treatment vs. case
miRNA	log2 FC	Relevance to Neuropsychiatric disease	Ref	miRNA	log2FC	Relevance to Neuropsychiatric disease	Ref
miR-1298	1.70	NA		miR-7a-5p	−1.10	NA
miR-139-5p	1.28	May Marks sensitivity to stress	[22]	miR-181a-2-3p	1.05	Related to Cerebral cavernous malformations	[23]
miR-139-3p	1.41	↓by Nerve Growth Factor treatment	[24]	miR-200a-3p	1.02	Mediate antidepressant-like effects in stressed rat	[25]
miR-34c-5p	1.23	↓in blood&brain of MDD patients	[26, 27]	miR-214-3p	−2.05	adjusts Depressive-like Behaviors	[28]
miR-448-3p	1.61	NA		miR-32-3p	−1.24	NA
miR-204-5p	1.07	Suppressed by morphine	[29]	miR-6215	4.16	NA
miR-10b-5p	−1.29	Related to Parkinson disease	[30]	miR-653-5p	− 1.02	NA
miR-214-3p	2.02	adjusts Depressive-like Behaviors	[31]	miR-10b-5p	1.36	Related to Parkinson disease	[30]

ISSN: 1472-6947