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Table 3 The top 5 AEs with the largest difference between adjusted odds ratio and the unadjusted odds ratio

From: Comparing drug safety of hepatitis C therapies using post-market data

FAERS Cerner Health Facts EHR
AE name OR(CI) before adjustment OR(CI) after adjustment AE name OR(CI) before adjustment OR(CI) after adjustment
“Ascites” 2.04 (1.66, 2.52) 1.73 (1.40, 2.14) “Weight decreased” 3.31(1.88, 5.82) 2.96(1.68, 5.21)
“Blood Bilirubin Increased” 1.98 (1.55, 2.51) 1.79 (1.41, 2.29) “Dizziness” 1.51(0.97, 2.34) 1.85(1.18, 2.90)
“Headache” 1.74 (1.59, 1.90) 1.87 (1.71, 2.05) “Dyspnoea” 1.78(1.41, 2.23) 2.01(1.59, 2.54)
“Off Label Use” 5.58 (2.72, 6.58) 5.49 (4.64, 6.51) “Pneumonia” 2.11(1.75, 2.54) 2.27(1.88, 2.74)
“Abdominal Pain” 1.15 (0.95, 1.42) 1.23 (1.00, 1.51) “Diarrhoea” 1.72(1.37, 2.17) 1.60(1.27, 2.01)