Table 5 Level 3 variant frequency by gene and number of tests
Gene | Number of Variants | Number of Tests | % of Tests |
|---|---|---|---|
TP53 | 310 | 280 | 0.43 |
ATM | 158 | 139 | 0.21 |
CDKN2A | 96 | 91 | 0.14 |
BRCA2 | 101 | 90 | 0.14 |
PTEN | 85 | 74 | 0.11 |
BRCA1 | 69 | 61 | 0.09 |
PIK3CA | 63 | 56 | 0.09 |
TSC2 | 45 | 44 | 0.07 |
KDR | 43 | 41 | 0.06 |
NF1 | 50 | 41 | 0.06 |
MET | 37 | 37 | 0.06 |
RB1 | 37 | 37 | 0.06 |
PTCH1 | 37 | 34 | 0.05 |
STK11 | 30 | 28 | 0.04 |
FBXW7 | 25 | 25 | 0.04 |
NF2 | 24 | 24 | 0.04 |
NRAS | 23 | 23 | 0.04 |
APC | 23 | 22 | 0.03 |
TSC1 | 23 | 21 | 0.03 |
KRAS | 19 | 18 | 0.03 |
IDH1 | 18 | 17 | 0.03 |
CDK4 | 18 | 17 | 0.03 |
CSF1R | 15 | 14 | 0.02 |
EGFR | 14 | 12 | 0.02 |
BRAF | 13 | 11 | 0.02 |
ERBB2 | 15 | 11 | 0.02 |
FGFR3 | 12 | 10 | 0.02 |
FGFR1 | 10 | 9 | 0.01 |
AKT1 | 8 | 8 | 0.01 |
SMO | 9 | 8 | 0.01 |
MSH2 | 9 | 6 | 0.01 |
CCND1 | 6 | 6 | 0.01 |
KIT | 7 | 6 | 0.01 |
PIK3R1 | 6 | 6 | 0.01 |
RET | 6 | 6 | 0.01 |
SMARCB1 | 5 | 4 | 0.01 |
CHEK2 | 4 | 4 | 0.01 |
CCNE1 | 4 | 4 | 0.01 |
MYC | 4 | 4 | 0.01 |
BAP1 | 4 | 4 | 0.01 |
ERBB4 | 3 | 3 | <.01 |
DDR2 | 3 | 3 | <.01 |
FLT3 | 3 | 3 | <.01 |
MAP2K1 | 3 | 3 | <.01 |
ALK | 3 | 3 | <.01 |
ESR1 | 2 | 2 | <.01 |
GNA11 | 2 | 2 | <.01 |
ERBB3 | 2 | 2 | <.01 |
HRAS | 2 | 2 | <.01 |
ABL1 | 2 | 2 | <.01 |
JAK2 | 2 | 2 | <.01 |
MTOR | 2 | 2 | <.01 |
MYCL | 2 | 2 | <.01 |
NFE2L2 | 2 | 2 | <.01 |
NTRK1 | 2 | 2 | <.01 |
MAPK1 | 2 | 2 | <.01 |
AR | 1 | 1 | <.01 |
CDK6 | 1 | 1 | <.01 |
FGFR2 | 1 | 1 | <.01 |
JAK1 | 1 | 1 | <.01 |
WT1 | 1 | 1 | <.01 |
MDM2 | 1 | 1 | <.01 |
NTRK3 | 1 | 1 | <.01 |
RAF1 | 1 | 1 | <.01 |
SRC | 1 | 1 | <.01 |
IDH2 | 1 | 1 | <.01 |