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Table 2 Parameters of base case and sensitivity analyses. There were no CKD 1 patients as the initial eGFR was below 90 mL/min/1.73 m^2. Hence, we did not perform sensitivity analyses of mortality rate, utility, and cost for CKD 1 patients

From: The effect of model selection on cost-effectiveness research: a comparison of kidney function-based microsimulation and disease grade-based microsimulation in chronic kidney disease modeling

Parameters Baseline values Sensitivity analyses Ref.
Lower limit Upper limit
Mean of eGFR decline speed (mL/min/1.73 m^2/year) 2.2 0.1 10 [33]
Standard Deviation of eGFR delcline speed (mL/min/1.73 m^2/year) 6.5 0.1 10 [33]
Initial age (years) 37 30 60 [33]
Initial eGFR (mL/min/1.73 m^2) 73 30 75 [33]
Baseline mortality rate of predialysis patients 3.338 × 10−5 × e0.091 × age(male)
1.615 × 10−5 × e0.098 × age(female)
× 0.8 × 1.2 [34, 35]
Mortality rate of CKD 1 patients Baseline × 1 × 0.9 × 1.1 [36]
Mortality rate of CKD 2 patients Baseline × 1 × 0.9 × 1.1 [36]
Mortality rate of CKD 3a patients Baseline × 1.2 × 1.1 × 1.3 [36]
Mortality rate of CKD 3b patients Baseline × 1.8 × 1.7 × 1.9 [36]
Mortality rate of CKD 4 patients Baseline × 3.2 × 3.0 × 3.4 [36]
Mortality rate of CKD 5 patients Baseline × 5.9 × 5.6 × 6.2 [36]
Mortality rate of dialysis patients 1.32 × 10−3 × e0.060 × age × 0.8 × 1.2 [36]
Utility of CKD 1 patients 1 0.9 1 [12]
Utility of CKD 2 patients 0.9 0.8 1 [12]
Utility of CKD 3a patients 0.87 0.77 0.97 [12]
Utility of CKD 3b patients 0.85 0.75 0.95 [12]
Utility of CKD 4 patients 0.85 0.75 0.95 [12]
Utility of CKD 5 patients 0.85 0.75 0.95 [12]
Utility of dialysis patients 0.72 0.62 0.82 [12]
Cost of CKD 1 (1000 USD / year) 1.6 0.8 3.2 [46]
Cost of CKD 2 (1000 USD / year) 1.7 0.9 3.4 [46]
Cost of CKD 3a (1000 USD / year) 3.5 1.8 7.0 [46]
Cost of CKD 3b (1000 USD / year) 3.5 1.8 7.0 [46]
Cost of CKD 4 (1000 USD / year) 12.7 6.4 25.4 [46]
Cost of CKD 5 (1000 USD / year) 12.7 6.4 25.4 [46]
Cost of dialysis patients (1000 USD / year) 84.6 42.3 169.1 [2]
Improve rate of eGFR decline slope 0.59 0.1 0.9 [33]
Annual discount rate for costs 0.03 0 0.1  
Annual discount rate for utilities 0.03 0 0.1  
  1. CKD Chronic kidney disease, eGFR Estimated glomerular filtration rate, Ref Reference