Table 6 Randomly chosen example association rules obtained for queries in Tables 4 and 5 and supporting literature

htnhist/HeartBEAT

hypertension-history

diabetes mellitus-history

hypercholesterolemia-history

None

htnhist/HeartBEAT

hypertension-history

diabetes mellitus-history

habitual snoring

[22–24]

tzd/SHHS

thiazolidinedione

hypertension-history

sulfonylurea, diabetes mellitus-history

None

tzd/SHHS

thiazolidinedione

hmg-coa reductase inhibitor

sulfonylurea, habitual snoring,

None

nonsteroidal anti-inflammatory drug,

hypercholesterolemia

biguanide/SHHS

biguanide

hypercholesterolemia

sulfonylurea, hypertension-history,

None

hmg-coa reductase inhibitor

biguanide/SHHS

biguanide

hypertension-history

sulfonylurea, hmg-coa reductase inhibitor,

None

hypercholesterolemia

chfhist/SHHS

congestive heart failure-history

angina pectoris

myocardial infarction-history

[32, 33]

chfhist/SHHS

congestive heart failure-history

loop diuretic

hypertension-history,

[19–21]

angiotensin converting enzyme inhibitor

typicalantipsychot/HCHS

Typical Antipsychotic

coronary artery disease-history

tricyclic antidepressant

None

typicalantipsychot/HCHS

Typical Antipsychotic

diabetes mellitus-history

tricyclic antidepressant

[34–36]

arb/SHHS

angiotensin 2 receptor blocker

chronic obstructive pulmonary

nonsteroidal anti-inflammatory drug,

[37–40]

disease/emphysema-history

habitual snoring, hypertension-history

arb/SHHS

angiotensin 2 receptor blocker

hypertension-history

nonsteroidal anti-inflammatory drug,

habitual snoring

None

cadhist/HCHS

coronary artery disease-history

angiotensin converting

thiazide diuretic, hypertension-history,

[22, 25, 26]

enzyme inhibitor

diabetes mellitus-history

cadhist/HCHS

coronary artery disease-history

persistent wheezing

hypertension-history

None

potassiumsalt/SHHS

potassium salt

loop diuretic

habitual snoring, hypertension-history

None

potassiumsalt/SHHS

potassium salt

habitual snoring

nonsteroidal anti-inflammatory drug,

hypertension-history

None

cvdishist/SHHS

cardiovascular disease-history

angina pectoris

nonsteroidal anti-inflammatory drug,

None

habitual snoring, hypertension-history

cvdishist/SHHS

cardiovascular disease-history

myocardial infarction-history

hypertension-history

[41]

ppmhist/SHHS

pacemaker placement

l-triiodothyronine

nonsteroidal anti-inflammatory drug

None

ppmhist/SHHS

pacemaker placement

nonsteroidal

chronic obstructive pulmonary

None

anti-inflammatory drug

disease/emphysema-history,

hypertension-history, habitual snoring

depresshist/HeartBEAT

depression

chronic obstructive pulmonary

hypercholesterolemia-history,

None

disease/emphysema - history

habitual snoring, hypertension-history

depresshist/HeartBEAT

depression

anxiety disorder

hypercholesterolemia-history,

None

habitual snoring, hypertension-history

dmhist/HeartBEAT

diabetes mellitus-history

anxiety disorder

depression, habitual snoring

[42–45]

hypertension-history

dmhist/HeartBEAT

diabetes mellitus-history

asthma

hypercholesterolemia-history,

[40, 46–48]

habitual snoring, hypertension-history

mihist/HeartBEAT

myocardial infarction-history

chronic obstructive pulmonary

hypercholesterolemia-history,

None

disease/emphysema-history

habitual snoring, hypertension-history

mihist/HeartBEAT

myocardial infarction-history

depression,

hypercholesterolemia-history,

None

diabetes mellitus-history

hypertension-history

triiodothy/SHHS

I-triiodothyronine

hypercholesterolemia

habitual snoring,

None

hmg-coa reductase inhibitor

triiodothy/SHHS

I-triiodothyronine

hypercholesterolemia

nonsteroidal anti-inflammatory drug,

None

hmg-coa reductase inhibitor

copdhist/HeartBEAT

chronic obstructive pulmonary

anxiety disorder

hypercholesterolemia-history,

[48–51]

disease/emphysema-history

habitual snoring, hypertension-history

copdhist/HeartBEAT

chronic obstructive pulmonary

asthma

hypercholesterolemia-history,

None

disease/emphysema-history

habitual snoring

h2blocker/SHHS

histamine-2 receptor antagonist

angiotensin converting

nonsteroidal anti-inflammatory drug,

None

enzyme inhibitor

habitual-snoring, hypertension-history

h2blocker/SHHS

histamine-2 receptor antagonist

hypertension-history

nonsteroidal anti-inflammatory drug,

None

habitual snoring

anixietyhist/HeartBEAT

anxiety disorder

habitual snoring

hypercholesterolemia-history,

[40, 44, 48, 52]

depression, hypertension-history

anixietyhist/HeartBEAT

anxiety disorder

myocardial infarction-history

hypercholesterolemia-history,

[48, 53, 54]

depression, hypertension-history

[44]

asthmahist/HeartBEAT

asthma

depression

chronic obstructive pulmonary

None

disease/emphysema-history,

hypercholesterolemia-history

asthmahist/HeartBEAT

asthma

hypertension-history

diabetes mellitus-history

[55, 56]

nsaid/HCHS

nonsteroidal

hypertension-history

thiazide diuretic

[57, 58]

anti-inflamatory drug

nsaid/HCHS

nonsteroidal

leukotriene receptor

asthma, persistent wheezing

None

anti-inflamatory drug

antagonist

strokehist/SHHS

stroke-history

myocardial infarction-history

hypertension-history

[41, 59]

strokehist/SHHS

stroke-history

chronic obstructive pulmonary

nonsteroidal anti-inflammatory drug,

None

disease/emphysema-history

hypertension-history