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Table 3 PheWAS Analysis: ICD-10 Codes Associate with Both Mortality and Borderline Dysnatremia

From: Association between borderline dysnatremia and mortality insight into a new data mining approach

ICD-10 codes Association with mortality
OR (IC95%)
P Value Association with dysnatremia
OR (IC95%)
P Value
Boderline Hyponatremia
 A41 Other sepsis 4.7 (3.1–6.88) < 0.001 5.83 (4.4–7.69) < 0.001
 I20 Angina pectoris 0.23 (0.13–0.37) < 0.001 0.67 (0.55–0.79) < 0.001
 I25 Chronic ischemic heart disease 0.47 (0.34–0.64) < 0.001 0.53 (0.44–0.62) < 0.001
 I48 Atrial fibrillation and flutter 0.15 (0.07–0.3) < 0.001 0.62 (0.5–0.76) < 0.001
 I71 Aortic aneurysm and dissection 2.37 (1.9–2.92) < 0.001 0.66 (0.53–0.8) < 0.001
 J15 Bacterial pneumonia, not elsewhere classified 2.9 (1.94–4.16) < 0.001 2.75 (2.13–3.51) < 0.001
 J80 Acute respiratory distress syndrome 30.64 (23.27–40.36) < 0.001 3.1 (2.28–4.17) < 0.001
 J96 Respiratory failure, not elsewhere classified 6.14 (5.19–7.22) < 0.001 2.29 (1.98–2.63) < 0.001
 K65 Peritonitis 6.53 (4.46–9.3) < 0.001 3.19 (2.32–4.33) < 0.001
 R07 Pain in throat and chest 0.1 (0.02–0.3) < 0.001 0.35 (0.23 0.5) < 0.001
 R57 Shock, not elsewhere classified 18.73 (15.81–22.16) < 0.001 3.56 (3.01–4.21) < 0.001
 Z48 Encounter for other postprocedural aftercare 0.63 (0.51–0.77) < 0.001 0.62 (0.55–0.7) < 0.001
 Z51 Encounter for other aftercare 2.46 (1.97–3.04) < 0.001 1.95 (1.68–2.25) < 0.001
Borderline Hypernatremia
 J69 Pneumonitis due to solids and liquids 8.3 (3.53–17.2) < 0.001 18.12 (6.74–40.49) < 0.001
 J80 Acute respiratory distress syndrome 36.98 (26.99–50.73) < 0.001 6.96 (3.4–12.65) < 0.001
 J96 Respiratory failure, not elsewhere classified 6.88 (5.68–8.28) < 0.001 2.95 (1.91–4.36) < 0.001
 N17 Acute kidney failure 3.33 (2.21–4.81) < 0.001 5.84 (3.41–9.33) < 0.001
 R57 Shock, not elsewhere classified 22.39 (18.37–27.23) < 0.001 6.19 (4.01–9.13) < 0.001
 Z51 Encounter for other aftercare 7.05 (4.32–10.98) < 0.001 7.93 (3.7–14.89) < 0.001