Table 3 PheWAS Analysis: ICD-10 Codes Associate with Both Mortality and Borderline Dysnatremia
From: Association between borderline dysnatremia and mortality insight into a new data mining approach
ICD-10 codes | Association with mortality OR (IC95%) | P Value | Association with dysnatremia OR (IC95%) | P Value |
|---|---|---|---|---|
Boderline Hyponatremia | ||||
 A41 Other sepsis | 4.7 (3.1–6.88) | < 0.001 | 5.83 (4.4–7.69) | < 0.001 |
 I20 Angina pectoris | 0.23 (0.13–0.37) | < 0.001 | 0.67 (0.55–0.79) | < 0.001 |
 I25 Chronic ischemic heart disease | 0.47 (0.34–0.64) | < 0.001 | 0.53 (0.44–0.62) | < 0.001 |
 I48 Atrial fibrillation and flutter | 0.15 (0.07–0.3) | < 0.001 | 0.62 (0.5–0.76) | < 0.001 |
 I71 Aortic aneurysm and dissection | 2.37 (1.9–2.92) | < 0.001 | 0.66 (0.53–0.8) | < 0.001 |
 J15 Bacterial pneumonia, not elsewhere classified | 2.9 (1.94–4.16) | < 0.001 | 2.75 (2.13–3.51) | < 0.001 |
 J80 Acute respiratory distress syndrome | 30.64 (23.27–40.36) | < 0.001 | 3.1 (2.28–4.17) | < 0.001 |
 J96 Respiratory failure, not elsewhere classified | 6.14 (5.19–7.22) | < 0.001 | 2.29 (1.98–2.63) | < 0.001 |
 K65 Peritonitis | 6.53 (4.46–9.3) | < 0.001 | 3.19 (2.32–4.33) | < 0.001 |
 R07 Pain in throat and chest | 0.1 (0.02–0.3) | < 0.001 | 0.35 (0.23 0.5) | < 0.001 |
 R57 Shock, not elsewhere classified | 18.73 (15.81–22.16) | < 0.001 | 3.56 (3.01–4.21) | < 0.001 |
 Z48 Encounter for other postprocedural aftercare | 0.63 (0.51–0.77) | < 0.001 | 0.62 (0.55–0.7) | < 0.001 |
 Z51 Encounter for other aftercare | 2.46 (1.97–3.04) | < 0.001 | 1.95 (1.68–2.25) | < 0.001 |
Borderline Hypernatremia | ||||
 J69 Pneumonitis due to solids and liquids | 8.3 (3.53–17.2) | < 0.001 | 18.12 (6.74–40.49) | < 0.001 |
 J80 Acute respiratory distress syndrome | 36.98 (26.99–50.73) | < 0.001 | 6.96 (3.4–12.65) | < 0.001 |
 J96 Respiratory failure, not elsewhere classified | 6.88 (5.68–8.28) | < 0.001 | 2.95 (1.91–4.36) | < 0.001 |
 N17 Acute kidney failure | 3.33 (2.21–4.81) | < 0.001 | 5.84 (3.41–9.33) | < 0.001 |
 R57 Shock, not elsewhere classified | 22.39 (18.37–27.23) | < 0.001 | 6.19 (4.01–9.13) | < 0.001 |
 Z51 Encounter for other aftercare | 7.05 (4.32–10.98) | < 0.001 | 7.93 (3.7–14.89) | < 0.001 |