Table 1 Hypothetical dataset used in the case study
Criterion | Direction | Patient weight (SD) (n = 100) | Expert weight (SD) (n = 5) | Drug A performance (events / n) | Drug B performance (events / n) | Drug C performance (events / n) | Placebo performance (events / n) |
|---|---|---|---|---|---|---|---|
Probability of response | Maximize | 0.46 (0.04) | 0.01 (0.03) | 5500 / 7000 | 6000 / 7000 | 84 / 100 | 250 / 1000 |
Probability of remission | Maximize | 0.19 (0.02) | 0.69 (0.07) | 6000 / 7000 | 5000 / 7000 | 84 / 100 | 250 / 1000 |
Probability of adverse event | Minimize | 0.14 (0.03) | 0.13 (0.10) | 300 / 7000 | 300 / 7000 | 1 / 100 | 5 / 1000 |
Probability of severe adverse event | Minimize | 0.21 (0.02) | 0.08 (0.08) | 30 / 7000 | 30 / 7000 | 0 / 100 | 50 / 1000 |