Figure 5

An excerpt of a CDS rule derived from the warfarin drug label. This rule provides a specific warfarin dosage range for treatment initiation in patients having CYP2C9 alleles *1 and *3 and being homozygous for the ‘T’ variant of the SNP rs9923231 in the VKORC1 gene. The “relevant_for” annotation indicates the type of drug that this recommendation is related to. The “CDS_message” annotation represents the textual description of the drug dosage recommendation. The “source” annotation provides the name of the source repository where the drug dosage recommendation was available. The “recommendations_importance” is a manually curated annotation indicates whether a rule recommends standard treatment, a minor deviation from standard treatment, or an important/critical modification of treatment.