Figure 3

Example of thea prioriINR prediction function. This shows an example of an a priori INR prediction for a 20 year old, with bodyweight 75 kg, genotypes CYP2C9 *3/*3 and VKORC1 A/G, with a target INR of 2.0-3.0 and a baseline INR of 1. The predicted INR after a total of 15 doses, including a 3-day loading dose regimen of 7.5 mg, 5 mg and 5 mg (not seen here but defined in the Set doses option) and followed by daily doses of 1.5 mg, is an INR of 2.57. The graph indicate that a target INR is reached after ~3 days with this dose regimen.