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Table 2 Current population pharmacokinetic parameter priors used to forecast methotrexate plasma concentrations in pediatric patients

From: Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy

Parameter

Units

Estimate

BSV

CLN

L/h

8.13

41.2%

CLR

L/h

2.59

82.0%

V1

L

39.6

21.0%

V2

L

3.94

47.6%

Q

L/h

0.113

7.56%

  1. CLN – Clearance in patients with normal renal function
  2. CLR – Clearance in patients with reduced renal function
  3. V1 – Volume of distribution in the central compartment
  4. V2 – Volume of distribution in the peripheral compartment
  5. Q – Inter-compartmental clearance
  6. BSV – Between subject variability
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BMC Medical Informatics and Decision Making

ISSN: 1472-6947

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