Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age

Table 5 SD_res results for children born SGA, giving the first, second and third year response. Model group (left) and total Validation group (right). SDstandRes gives the ratio SD_res/SD_resModelgroup, 2cm 3 y gives the 2 SD prediction interval in cm at 3 years of age and 2cm 7 y gives this interval at 7 years of age.

	Model group					Validation group
Models	n	SD_res	SDstand _Res	2*cm 3 y	2*cm 7 y	n	SD_res
1 yr response
A. Auxological model	144	0.221	0.96	1.6	2.3	34	0.211
B. Auxological+endocrine models
IGF+leptin	83	0.188	0.98	1.4	1.9	25	0.177
GH_AITT+IGF+leptin	72	0.186	0.97	1.4	1.9	20	0.185
GH_{24 h}	77	0.169	1.03	1.2	1.7	18	0.137
GH_{24 h}+IGF+leptin	68	0.167	1.08	1.2	1.7	17	0.107
2 yrs response
A. Auxological model	112	0.326	0.96	2.4	3.4	27	0.343
B. Auxological+endocrine models
IGF+leptin	69	0.284	1.07	2.1	2.9	21	0.295
GH_AITT+IGF+leptin	61	0.268	1.03	2.0	2.8	16	0.270
GH_{24 h}	60	0.292	1.06	2.1	3.0	15	0.297
GH_{24 h}+IGF+leptin	55	0.266	1.08	1.9	2.7	13	0.280
3 yrs response
A. Auxological model	77	0.440	1.02	3.2	4.5	9	0.459
B. Auxological+endocrine models
IGF+leptin	49	0.338	1.03	2.5	3.5	7	0.361
GH_AITT+IGF+leptin	43	0.321	0.98	2.3	3.3	4	0.326
GH_{24 h}	42	0.388	1.10	2.8	4	6	0.380
GH_{24 h}+IGF+leptin	39	0.336	1.10	2.5	3.5	5	0.361

ISSN: 1472-6947