At birth
| | | | | | | | | | |
Gestational age (weeks)
|
39.4
|
1.3
|
37
|
42
|
144
|
39.2
|
1.5
|
37
|
42
|
34
|
Height SDS
|
-2.58
|
0.93
|
-5.8
|
-0.5
|
144
|
-2.55
|
0.84
|
-5.4
|
-0.9
|
34
|
Weight SDS
|
-2.25
|
0.89
|
-4.5
|
0.4
|
144
|
-2.19
|
0.80
|
-4.4
|
-0.6
|
34
|
Pretreatment
| | | | | | | | | | |
Δheight SDS during pretreat yr
|
0.02
|
0.19
|
-0.5
|
0.6
|
134
|
0.03
|
0.19
|
-0.3
|
0.7
|
32
|
GHmax of GH-profile
|
47.8
|
27.8
|
11.7
|
146.9
|
77
|
38.5
|
23.6
|
14.2
|
98.1
|
18
|
GHmax during AITT
|
34.6
|
26.2
|
3.0
|
160
|
133
|
24.3
|
17.8
|
5.9
|
76.1
|
28
|
At GH start
| | | | | | | | | | |
SEX (min = girls, max = boys)
| | |
34
|
110
|
144
| | |
14
|
20
|
34
|
Age (yrs)
|
8.1
|
2.51
|
3.1
|
13.3
|
144
|
7.8
|
2.20
|
3.2
|
11.4
|
34
|
Height SDS
|
-3.04
|
0.65
|
-4.8
|
-1.5
|
144
|
-2.94
|
0.54
|
-4.2
|
-2.0
|
34
|
Weight SDS
|
-2.79
|
1.05
|
-6.2
|
1.6
|
144
|
-2.71
|
0.98
|
-4.9
|
0.0
|
34
|
Father height SDS
|
-1.07
|
1.17
|
-4.9
|
1.9
|
144
|
-0.93
|
1.00
|
-2.8
|
1.7
|
34
|
Mother height SDS
|
-1.39
|
1.09
|
-3.6
|
1.2
|
144
|
-1.28
|
0.97
|
-3.1
|
1.0
|
34
|
Diff SDS
|
-2.29
|
0.82
|
-4.6
|
-0.4
|
144
|
-2.27
|
0.83
|
-5.1
|
-0.8
|
34
|
IGF SDS
|
-0.81
|
1.46
|
-7.4
|
3.0
|
87
|
-1.02
|
1.64
|
-4.0
|
2.7
|
25
|
Leptin (ng/mL)
|
3.65
|
3.24
|
1.2
|
27.8
|
92
|
3.12
|
1.05
|
1.7
|
5.3
|
25
|
During treatment
| | | | | | | | | | |
GH dose (IU/kg/day)
|
0.11
|
0.03
|
0.07
|
0.22
|
144
|
0.11
|
0.02
|
0.09
|
0.18
|
34
|
Change in height SDS 1st yr
|
0.7
|
0.28
|
0.1
|
2.0
|
144
|
0.64
|
0.19
|
0.1
|
1.0
|
34
|
Change in height SDS two yrs
|
1.1
|
0.41
|
0.2
|
3.0
|
108
|
1.03
|
0.32
|
0.4
|
1.9
|
26
|
|
c. Model group
|
d. Validation group
|
At birth
| | | | | | | | | | |
Gestational age (weeks)
|
34.4
|
1.7
|
30
|
36
|
36
|
34.4
|
2.5
|
27
|
36
|
11
|
Height SDS
|
-2.57
|
1.96
|
-8.1
|
0.7
|
36
|
-1.75
|
1.55
|
-4.0
|
1.4
|
11
|
Weight SDS
|
-2.18
|
1.66
|
-6.1
|
0.7
|
36
|
-1.78
|
1.6
|
-3.5
|
1.8
|
11
|
Pretreatment
| | | | | | | | | | |
Δheight SDS during pretreat yr
|
-0.05
|
0.22
|
-0.4
|
0.5
|
32
|
0.03
|
0.1
|
-0.1
|
0.2
|
11
|
GHmax of GH-profile
|
44.1
|
25.9
|
14.3
|
134
|
22
|
28.6
|
10.5
|
15.4
|
48.9
|
10
|
GHmax during AITT
|
28.6
|
15.1
|
8.5
|
70.4
|
33
|
38.3
|
17.4
|
8.8
|
63.8
|
10
|
At GH start
| | | | | | | | | | |
SEX (min = girls, max = boys)
| | |
7
|
29
|
36
| | |
5
|
6
|
11
|
Age (yrs)
|
7.89
|
2.91
|
2.8
|
14.6
|
36
|
6.69
|
1.32
|
4.8
|
9.0
|
11
|
Height SDS
|
-2.84
|
0.59
|
-4.1
|
-1.5
|
36
|
-2.61
|
0.36
|
-3.2
|
-2.0
|
11
|
Weight SDS
|
-3.01
|
0.89
|
-5.2
|
-0.7
|
36
|
-2.40
|
1.14
|
-5.2
|
-0.2
|
11
|
Father height SDS
|
-1.16
|
0.88
|
-3.4
|
0.4
|
36
|
-0.40
|
1.21
|
-2.8
|
1.3
|
11
|
Mother height SDS
|
-1.02
|
0.89
|
-3.2
|
1.2
|
36
|
-0.68
|
1.26
|
-3.4
|
1.6
|
11
|
Diff SDS
|
-2.2
|
0.72
|
-3.5
|
-1.0
|
36
|
-2.36
|
0.52
|
-3.3
|
-1.3
|
11
|
IGF SDS
|
-1.54
|
1.19
|
-5.4
|
0.2
|
26
|
-1.12
|
1.41
|
-3.3
|
0.7
|
11
|
Leptin (ng/mL)
|
3.25
|
1.16
|
2.1
|
7.1
|
21
|
3.96
|
1.73
|
2.5
|
8
|
9
|
During treatment
| | | | | | | | | | |
GH dose (IU/kg/day)
|
0.11
|
0.03
|
0.08
|
0.19
|
36
|
0.14
|
0.03
|
0.10
|
0.18
|
11
|
Change in height SDS 1st yr
|
0.68
|
0.25
|
0.4
|
1.2
|
36
|
0.71
|
0.16
|
0.5
|
1.0
|
11
|
Change in height SDS two yrs
|
1.1
|
0.39
|
0.6
|
2.2
|
28
|
1.18
|
0.16
|
0.9
|
1.4
|
8
|