Table 2 Characteristics of children included born either SGA (a and b) or preterm (c and d). The data is presented for the Auxological model.

At birth

Gestational age (weeks)

39.4

1.3

37

42

144

39.2

1.5

37

42

34

   Height SDS

-2.58

0.93

-5.8

-0.5

144

-2.55

0.84

-5.4

-0.9

34

   Weight SDS

-2.25

0.89

-4.5

0.4

144

-2.19

0.80

-4.4

-0.6

34

Pretreatment

Δheight SDS during pretreat yr

0.02

0.19

-0.5

0.6

134

0.03

0.19

-0.3

0.7

32

   GHmax of GH-profile

47.8

27.8

11.7

146.9

77

38.5

23.6

14.2

98.1

18

   GHmax during AITT

34.6

26.2

3.0

160

133

24.3

17.8

5.9

76.1

28

At GH start

   SEX (min = girls, max = boys)

34

110

144

14

20

34

   Age (yrs)

8.1

2.51

3.1

13.3

144

7.8

2.20

3.2

11.4

34

   Height SDS

-3.04

0.65

-4.8

-1.5

144

-2.94

0.54

-4.2

-2.0

34

   Weight SDS

-2.79

1.05

-6.2

1.6

144

-2.71

0.98

-4.9

0.0

34

   Father height SDS

-1.07

1.17

-4.9

1.9

144

-0.93

1.00

-2.8

1.7

34

   Mother height SDS

-1.39

1.09

-3.6

1.2

144

-1.28

0.97

-3.1

1.0

34

   Diff SDS

-2.29

0.82

-4.6

-0.4

144

-2.27

0.83

-5.1

-0.8

34

   IGF SDS

-0.81

1.46

-7.4

3.0

87

-1.02

1.64

-4.0

2.7

25

   Leptin (ng/mL)

3.65

3.24

1.2

27.8

92

3.12

1.05

1.7

5.3

25

During treatment

   GH dose (IU/kg/day)

0.11

0.03

0.07

0.22

144

0.11

0.02

0.09

0.18

34

   Change in height SDS 1st yr

0.7

0.28

0.1

2.0

144

0.64

0.19

0.1

1.0

34

   Change in height SDS two yrs

1.1

0.41

0.2

3.0

108

1.03

0.32

0.4

1.9

26

c. Model group

d. Validation group

At birth

Gestational age (weeks)

34.4

1.7

30

36

36

34.4

2.5

27

36

11

   Height SDS

-2.57

1.96

-8.1

0.7

36

-1.75

1.55

-4.0

1.4

11

   Weight SDS

-2.18

1.66

-6.1

0.7

36

-1.78

1.6

-3.5

1.8

11

Pretreatment

Δheight SDS during pretreat yr

-0.05

0.22

-0.4

0.5

32

0.03

0.1

-0.1

0.2

11

   GHmax of GH-profile

44.1

25.9

14.3

134

22

28.6

10.5

15.4

48.9

10

   GHmax during AITT

28.6

15.1

8.5

70.4

33

38.3

17.4

8.8

63.8

10

At GH start

   SEX (min = girls, max = boys)

7

29

36

5

6

11

   Age (yrs)

7.89

2.91

2.8

14.6

36

6.69

1.32

4.8

9.0

11

   Height SDS

-2.84

0.59

-4.1

-1.5

36

-2.61

0.36

-3.2

-2.0

11

   Weight SDS

-3.01

0.89

-5.2

-0.7

36

-2.40

1.14

-5.2

-0.2

11

   Father height SDS

-1.16

0.88

-3.4

0.4

36

-0.40

1.21

-2.8

1.3

11

   Mother height SDS

-1.02

0.89

-3.2

1.2

36

-0.68

1.26

-3.4

1.6

11

   Diff SDS

-2.2

0.72

-3.5

-1.0

36

-2.36

0.52

-3.3

-1.3

11

   IGF SDS

-1.54

1.19

-5.4

0.2

26

-1.12

1.41

-3.3

0.7

11

   Leptin (ng/mL)

3.25

1.16

2.1

7.1

21

3.96

1.73

2.5

8

9

During treatment

   GH dose (IU/kg/day)

0.11

0.03

0.08

0.19

36

0.14

0.03

0.10

0.18

11

   Change in height SDS 1st yr

0.68

0.25

0.4

1.2

36

0.71

0.16

0.5

1.0

11

   Change in height SDS two yrs

1.1

0.39

0.6

2.2

28

1.18

0.16

0.9

1.4

8