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Table 3 The E-M iteration results for a Three-state Markov model taking age as a covariate in proportional hazard regression model

From: Estimation of progression of multi-state chronic disease using the Markov model and prevalence pool concept

  Parameter
Iteration β (≥ 50 yrs) (< 50 yrs)
  (95% CI) λ 11 λ 21 λ 12 λ 22
----- --------- ---------- 0.0926 ---------- 0.1934
1 0.7008 0.0151 0.0926 0.0075 0.1933
2 0.7008 0.0151 0.0926 0.0075 0.1933
3 0.7008 0.0151 0.0926 0.0075 0.1933
  (0.0681~7.2133)     
  1. λ 11 &λ 12:normal → asymptomatic.
  2. λ 21 &λ 22:asymptomatic → symptomatic