Screenshot of ISABEL simulated study procedure – step 2. This figure shows how the same subject was provided the results of ISABEL's search in one click, and how he was provided the opportunity to modify the clinical decisions made in step 1. It was not possible to go back from this step to step 1 to modify the clinical decisions made earlier. Notice that the subject has not identified meningitis/encephalitis from the ISABEL suggestions as clinically important. He has made no changes to his workup, and has committed a DEO despite system advice.