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Table 1 Methodologic Rigor Applied for Studies of Causation

From: Developing optimal search strategies for detecting clinically sound and relevant causation studies in EMBASE

Purpose Category Methodologic Rigor
Causation Observation concerned with the relationship between exposures and putative clinical outcomes;
Data collection is prospective;
Clearly identified comparison group(s);
Blinding of observers of outcome to exposure;
and Analysis consistent with study design.