Figure 1

Overview of the study framework. First, data were integrated from multiple sources, including data on drug-ADE associations from two different sources (Lexi-comp and SIDER), drug and ADE taxonomies, and intrinsic drug properties. Next, a number of steps to standardize and integrate these data were carried out. The strength of the association between the counts of ADEs and drugs in Lexi-comp and SIDER data sets and the differences between these two data sets were assessed. Finally, a PPN model was trained using a 2005 version of Lexi-comp and validated using both Lexi-comp 2010 and SIDER 2012 as reference standards.