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Table 1 Main rules for aggregation of events into states

From: Temporal representation of care trajectories of cancer patients using data from a regional information system: an application in breast cancer

State code* State Type of event to aggregate (time-lapse between two events for aggregation) Dating
A AP ≥ 1 pathology investigations (less that 3 months apart) Sampling Date
If several:
Start: date of first investigation
End: date of last investigation
C SURG ≥ 1 surgical acts (less than 3 months apart) Date of the act
If several:
Start: date of first surgery
End: date of last surgery
D SURG_AP ≥ 1 surgical acts (less than 3 months) apart AND ≥ 1 pathology investigations Date of the act, or else date of the sample.
If several:
Start: date of first surgery
End: date of last surgery
N CT_NEO ≥ 1 administrations of chemotherapy occurring before the first surgery Start: date of the first administration
End: date of the last administration
K CT ≥ 1 administrations of chemotherapy (less than 6 months apart) Start: date of the first administration
End: date of the last administration
R RT ≥ 1 radiotherapy sessions (less than 1 month apart) Start: date of the first session
End: date of the last session
O CT_RT Period of concomitant radiotherapy and chemotherapy Start: date of the first session of intercurrent RT or CT
End: date of the last session of intercurrent RT or CT
  1. *Each state is recoded by a character so as to represent the overall sequence in the form of an ordered chain of characters.