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Table 1 Main rules for aggregation of events into states

From: Temporal representation of care trajectories of cancer patients using data from a regional information system: an application in breast cancer

State code*

State

Type of event to aggregate (time-lapse between two events for aggregation)

Dating

A

AP

≥ 1 pathology investigations (less that 3 months apart)

Sampling Date

If several:

Start: date of first investigation

End: date of last investigation

C

SURG

≥ 1 surgical acts (less than 3 months apart)

Date of the act

If several:

Start: date of first surgery

End: date of last surgery

D

SURG_AP

≥ 1 surgical acts (less than 3 months) apart AND ≥ 1 pathology investigations

Date of the act, or else date of the sample.

If several:

Start: date of first surgery

End: date of last surgery

N

CT_NEO

≥ 1 administrations of chemotherapy occurring before the first surgery

Start: date of the first administration

End: date of the last administration

K

CT

≥ 1 administrations of chemotherapy (less than 6 months apart)

Start: date of the first administration

End: date of the last administration

R

RT

≥ 1 radiotherapy sessions (less than 1 month apart)

Start: date of the first session

End: date of the last session

O

CT_RT

Period of concomitant radiotherapy and chemotherapy

Start: date of the first session of intercurrent RT or CT

End: date of the last session of intercurrent RT or CT

  1. *Each state is recoded by a character so as to represent the overall sequence in the form of an ordered chain of characters.