|
No. of patients
|
148
|
(100)
|
143
|
(100)
|
174
|
(100)
| |
|
Age
| | | | | | |
<0.001
|
|
Median
|
55
|
60
|
50
| |
|
Range
|
(31–85)
|
(26–88)
|
(25–74)
| |
|
Body mass index
|
0.019
|
|
Median
|
22.9
|
22.3
|
23.2
| |
|
Range
|
(16.6–43.2)
|
(14.8–31.4)
|
(17.8–37)
| |
|
Unknown
|
3
|
(2)
|
0
|
(0)
|
1
|
(0.6)
| |
|
Clinical T classification
|
0.2621
|
|
T1
|
102
|
(68.9)
|
100
|
(69.9)
|
108
|
(62.1)
| |
|
T2
|
46
|
(31.1)
|
43
|
(30.1)
|
66
|
(37.9)
| |
|
Clinical N classification
|
0.002
|
|
N0
|
137
|
(92.6)
|
135
|
(94.4)
|
174
|
(100)
| |
|
N1
|
11
|
(7.4)
|
8
|
(5.6)
|
0
|
(0)
| |
|
Skin dimpling
|
<0.001
|
|
Yes
|
22
|
(14.9)
|
14
|
(9.8)
|
2
|
(1.1)
| |
|
No
|
109
|
(73.6)
|
129
|
(90.2)
|
172
|
(98.9)
| |
|
Unknown
|
17
|
(11.5)
|
0
|
(0)
|
0
|
(0)
| |
|
Nipple discharge
|
0.238
|
|
Yes
|
6
|
(4.1)
|
2
|
(1.4)
|
3
|
(1.7)
| |
|
No
|
138
|
(93.2)
|
141
|
(98.6)
|
170
|
(97.7)
| |
|
Unknown
|
4
|
(2.7)
|
0
|
(0)
|
1
|
(0.6)
| |
|
Mammography
| |
|
Presence of masses
|
0.284
|
|
Yes
|
90
|
(60.8)
|
88
|
(61.5)
|
102
|
(58.6)
| |
|
Focal asymmetry
|
22
|
(14.9)
|
20
|
(14)
|
39
|
(22.4)
| |
|
No
|
35
|
(23.6)
|
26
|
(18.2)
|
33
|
(19)
| |
|
Unknown
|
1
|
(0.7)
|
9
|
(6.3)
|
0
|
(0)
| |
|
Presence of calcifications
|
0.037
|
|
Yes
|
67
|
(45.3)
|
44
|
(30.8)
|
59
|
(33.9)
| |
|
No
|
81
|
(54.7)
|
94
|
(65.7)
|
115
|
(66.1)
| |
|
Unknown
|
0
|
(0)
|
5
|
(3.5)
|
0
|
(0)
| |
|
Shape of calcifications
|
0.010
|
|
Fine branching or casting
|
4
|
(6)
|
1
|
(2.3)
|
3
|
(5.1)
| |
|
Pleomorphic
|
9
|
(13.4)
|
11
|
(25)
|
21
|
(35.6)
| |
|
Amorphous or indistinct
|
43
|
(64.2)
|
27
|
(61.4)
|
35
|
(59.3)
| |
|
Round or benign
|
11
|
(16.4)
|
4
|
(9.1)
|
0
|
(0)
| |
|
Unknown
|
0
|
(0)
|
1
|
(2.3)
|
0
|
(0)
| |
|
Distribution of calcifications
|
0.024
|
|
Linear or segmented
|
26
|
(38.8)
|
14
|
(31.8)
|
22
|
(37.3)
| |
|
Grouped or clustered
|
30
|
(44.8)
|
29
|
(65.9)
|
36
|
(61)
| |
|
Regional or diffuse
|
9
|
(13.4)
|
1
|
(2.3)
|
1
|
(1.7)
| |
|
Unknown
|
2
|
(3)
|
0
|
(0)
|
0
|
(0)
| |
|
Ultrasonography
| | | | | | | |
|
Presence of masses
|
0.264
|
|
Yes
|
142
|
(95.9)
|
133
|
(93)
|
161
|
(92.5)
| |
|
No
|
5
|
(3.4)
|
10
|
(7)
|
13
|
(7.5)
| |
|
Unknown
|
1
|
(0.7)
|
0
|
(0)
|
0
|
(0)
| |
|
Multifocality
|
0.114
|
|
Yes
|
27
|
(19)
|
14
|
(10.5)
|
21
|
(13)
| |
|
No
|
115
|
(81)
|
119
|
(89.5)
|
140
|
(87)
| |
|
Maximum tumor size (mm)
|
0.004
|
|
Median
|
16
|
16.1
|
19
| |
|
Range
|
(4–37)
|
(5–35)
|
(4–37)
| |
|
Depth/width ratio
|
0.001
|
|
Median
|
0.72
|
0.67
|
0.64
| |
|
Range
|
(0.31–1.36)
|
(0.22–1.43)
|
(0.33–1.27)
| |
|
Unknown
|
0
|
(0)
|
9
|
(6.8)
|
0
|
(0)
| |
|
Echogenic halo
|
<0.001
|
|
Yes
|
32
|
(22.5)
|
62
|
(46.6)
|
38
|
(23.6)
| |
|
No
|
109
|
(76.8)
|
71
|
(53.4)
|
123
|
(76.4)
| |
|
Unknown
|
1
|
(0.7)
|
0
|
(0)
|
0
|
(0)
| |
|
Interruption of the anterior border of the mammary gland
|
0.807
|
|
Yes
|
99
|
(69.7)
|
91
|
(68.4)
|
106
|
(65.8)
| |
|
No
|
43
|
(30.3)
|
42
|
(31.6)
|
54
|
(33.5)
| |
|
Unknown
|
0
|
(0)
|
0
|
(0)
|
1
|
(0.6)
| |
|
Detection of LNs
|
0.130
|
|
Detectable
|
49
|
(33.1)
|
37
|
(25.9)
|
56
|
(32.2)
| |
|
Not detectable
|
82
|
(55.4)
|
105
|
(73.4)
|
117
|
(67.2)
| |
|
Unknown
|
17
|
(11.5)
|
1
|
(0.7)
|
1
|
(0.6)
| |
|
Maximum size (mm) of LNs
|
0.010
|
|
Median
|
11
|
10
|
10
| |
|
Range
|
(5–22)
|
(3–32)
|
(4–17)
| |
|
Unknown
|
0
|
(0)
|
4
|
(10.8)
|
1
|
(1.8)
| |
|
Hilum of LNs
|
0.021
|
|
Detectable
|
43
|
(87.8)
|
27
|
(73)
|
36
|
(64.3)
| |
|
Not detectable
|
6
|
(12.2)
|
9
|
(24.3)
|
20
|
(35.7)
| |
|
Unknown
|
0
|
(0)
|
1
|
(2.7)
|
0
|
(0)
| |
|
Histological type
|
0.584
|
|
Invasive ductal carcinoma
|
135
|
(91.2)
|
129
|
(90.2)
|
160
|
(92)
| |
|
Invasive lobular carcinoma
|
5
|
(3.4)
|
3
|
(2.1)
|
7
|
(4)
| |
|
Other specific types
|
8
|
(5.4)
|
11
|
(7.7)
|
7
|
(4)
| |
|
Estrogen receptor†
|
0.023
|
|
Positive
|
119
|
(80.4)
|
114
|
(79.7)
|
121
|
(69.5)
| |
|
Negative
|
27
|
(18.2)
|
29
|
(20.3)
|
53
|
(30.5)
| |
|
Unknown
|
2
|
(1.4)
|
0
|
(0)
|
0
|
(0)
| |
|
Progesterone receptor†
|
0.427
|
|
Positive
|
83
|
(56.1)
|
89
|
(62.2)
|
96
|
(55.2)
| |
|
Negative
|
63
|
(42.6)
|
54
|
(37.8)
|
78
|
(44.8)
| |
|
Unknown
|
2
|
(1.4)
|
0
|
(0)
|
0
|
(0)
| |
|
HER2‡
|
0.019
|
|
Positive
|
18
|
(12.2)
|
11
|
(7.7)
|
29
|
(16.7)
| |
|
Negative
|
121
|
(81.8)
|
131
|
(91.6)
|
125
|
(71.8)
| |
|
Unknown
|
9
|
(6.1)
|
1
|
(0.7)
|
20
|
(11.5)
| |
|
Histological/nuclear grade
|
<0.001
|
|
1
|
64
|
(43.2)
|
43
|
(30.1)
|
4
|
(2.3)
| |
|
2
|
47
|
(31.8)
|
63
|
(44.1)
|
82
|
(47.1)
| |
|
3
|
27
|
(18.2)
|
36
|
(25.2)
|
88
|
(50.6)
| |
|
Unknown
|
10
|
(6.8)
|
1
|
(0.7)
|
0
|
(0)
| |
|
LN metastasis
|
0.292
|
|
Yes
|
44
|
(29.7)
|
44
|
(30.8)
|
41
|
(23.6)
| |
|
No
|
104
|
(70.3)
|
99
|
(69.2)
|
133
|
(76.4)
| |
